DURLAZA

Peak

aspirin

NDAORALCAPSULE, EXTENDED RELEASE
Approved
Sep 2015
Lifecycle
Peak
Competitive Pressure
30/100
Clinical Trials
20

Mechanism of Action

[acetylsalicylic acid (ASA)] inhibits prostaglandin synthesis resulting in inhibition of platelet aggregation for their lifespan of about 7-10 days. The acetyl group of aspirin binds with a serine residue of cyclooxygenase-1 (COX-1) , resulting in irreversible inactivation of the enzyme. Inhibition…

Indications (10)

deathmyocardial infarction (MI) in patients with chronic coronary artery diseasesuchunstable angina pectorischronic stable anginato reduce the risk of deathrecurrent stroke in patientstransient ischemic attack Limitation of Use : Use immediate-release aspirinnot DURLAZA in situations where a rapid onset of action is required (suchbefore percutaneous coronary intervention)

Clinical Trials (5)

NCT07089862N/ANot Yet Recruiting

INdobufen Versus asPirin in Endovascular Unruptured Intracranial Aneurysms Treatment (INPUT)

Started Aug 2025
NCT06444178Phase 1Completed

Assessment of Gastrointestinal Blood Loss After Receiving Aspirin or Aspirin Plus Rivaroxaban, or Aspirin Plus REGN9933, or Aspirin Plus REGN7508 in Healthy Adult Participants

Started Sep 2024
224 enrolled
Healthy Volunteers
NCT05546957N/ACompleted

Assess Gastrointestinal Blood Loss After Receiving Aspirin or Aspirin Plus Rivaroxaban in Healthy Adult Participants

Started Jan 2023
60 enrolled
Healthy Volunteer
NCT05093790Phase 2Completed

A Study to Evaluate BMS-986141 Added on to Aspirin or Ticagrelor or the Combination, on Thrombus Formation in a Thrombosis Chamber Model in Participants With Stable Coronary Artery Disease and Healthy Participants

Started Mar 2022
58 enrolled
Coronary Artery DiseaseHealthy Participants
NCT05080946Phase 1Recruiting

Using Aspirin to Improve Immunological Features of Ovarian Tumors

Started Nov 2021
100 enrolled
Ovarian CancerFallopian Tube CancerPeritoneal Cancer
External Resources
DailyMed
Full prescribing information
FDA Drugs@FDA
FDA approval history
RxNorm
Drug nomenclature & identifiers