NDAINHALATIONSOLUTION
Approved
Mar 2001
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
DUONEB (albuterol sulfate; ipratropium bromide) by Teva is clinical pharmacology the prime action of beta-adrenergic drugs is to stimulate adenyl cyclase, the enzyme which catalyzes the formation of cyclic-3',5'-adenosine monophosphate (cyclic amp) from adenosine triphosphate (atp). Approved for bronchospasm associated with copd in patients requiring more than one bronchodilator, copd. First approved in 2001.
Drug data last refreshed Yesterday · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
DUONEB is a dual-bronchodilator inhaled solution combining albuterol sulfate (a short-acting beta-2 agonist) and ipratropium bromide (an anticholinergic) for treating bronchospasm in COPD patients requiring multiple bronchodilators. It works via two complementary mechanisms: albuterol stimulates adenyl cyclase to relax bronchial smooth muscle, while ipratropium blocks muscarinic receptors to prevent acetylcholine-induced bronchoconstriction. The combination provides rapid onset (within 5 minutes) and peak effect at approximately 1 hour.
LOE Approaching
Product is in the final years before loss of exclusivity, signaling a transition phase where commercial teams focus on market defense rather than expansion.
Mechanism of Action
CLINICAL PHARMACOLOGY The prime action of beta-adrenergic drugs is to stimulate adenyl cyclase, the enzyme which catalyzes the formation of cyclic-3',5'-adenosine monophosphate (cyclic AMP) from adenosine triphosphate (ATP). The cyclic AMP thus formed mediates the cellular responses. In vitro…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.