NDAORALCAPSULEPriority Review
Approved
Jul 1990
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Mechanism of Action
colon, colonic bacteria convert olsalazine into 5‑aminosalicylic acid (5-ASA or mesalazine). The mechanism of action of 5-ASA (mesalamine) is not fully understood, but appears to be a topical anti-inflammatory effect on colonic epithelial cells. Mucosal production of arachidonic acid metabolites,…