DIHYDROERGOTAMINE MESYLATE (dihydroergotamine mesylate) by Sagent Pharmaceuticals is clinical pharmacology mechanism of action dihydroergotamine binds with high affinity to 5-ht 1dα and 5-ht 1dβ receptors. Approved for migraine. First approved in 2018.
Drug data last refreshed 18h ago
CLINICAL PHARMACOLOGY Mechanism of Action Dihydroergotamine binds with high affinity to 5-HT 1Dα and 5-HT 1Dβ receptors. It also binds with high affinity to serotonin 5-HT 1A, 5-HT 2A, and 5-HT 2C receptors, noradrenaline α 2A, α 2B and α 1 receptors, and dopamine D 2L and D 3 receptors. The…
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Pharmacodynamic Study to Compare Acute Effects of Dihydroergotamine Mesylate (DHE) on Pulmonary Arterial Pressure
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