NDATOPICALCREAM
Approved
May 2000
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
4/8 — Partial
DIFFERIN (adapalene) by Galderma is mechanism of action: adapalene acts on retinoid receptors. First approved in 2000.
Drug data last refreshed 9h ago · AI intelligence enriched 5d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
DIFFERIN (adapalene) is a topical retinoid cream approved for acne vulgaris that normalizes follicular epithelial cell differentiation and reduces microcomedone formation. It binds to retinoic acid nuclear receptors to modulate cellular differentiation, keratinization, and inflammatory processes central to acne pathology. Adapalene represents a non-prescription retinoid option for mild-to-moderate acne management.
LOE Approaching
Product approaching loss of exclusivity with moderate competitive pressure (30/100), suggesting team downsizing and focus shift to cost management and generic transition strategy.
Mechanism of Action
Mechanism of Action: Adapalene acts on retinoid receptors. Biochemical and pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes all of which represent important features in the pathology of acne…
Pharmacologic Class:
Retinoid
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (20)
Clindamycin Phosphate, Adapalene, and Benzoyl Peroxide Triple Combination Gel in Canadian Patients With Acne Vulgaris
Started Oct 2025
200 enrolled
Acne Vulgaris
"A Comparative Clinical Evaluation of the Efficacy of Topical Adapalene, Benzoyl Peroxide Gel, Oral Lactobacillus Rhamnosus, D-chiro-inositol, Inulin Capsule, and Their Fixed Combination in Mild to Moderate Acne Vulgaris Patients."
Started Feb 2022
59 enrolled
Acne Vulgaris
Performance of Masimo MightySat Pulse Oximeter in Differing Levels of Skin Pigmentation
Started Oct 2021
88 enrolled
Healthy
Clinical Endpoint Bioequivalence Study of Adapalene Gel 0.1%
Started Jul 2020
0Acne Vulgaris
A Study to Compare FCD105 Foam to Minocycline 3% Foam, Adapalene 0.3% Foam and Vehicle Foam.
Started Sep 2019
446 enrolled
Acne Vulgaris
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.