NDAINTRAVENOUSINJECTABLE
Approved
Jul 2001
Lifecycle
Peak
Competitive Pressure
0/100
Clinical Trials
6
Data completeness
4/8 — Partial
DEFINITY (perflutren) by Lantheus Medical Imaging is ultrasound contrast activity [moa]. First approved in 2001.
Drug data last refreshed 2h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
DEFINITY (perflutren) is an intravenous ultrasound contrast agent composed of perfluorocarbon microbubbles that enhance cardiac ultrasound imaging by increasing blood pool echogenicity. It works by reflecting ultrasound waves, enabling improved visualization of cardiac chambers and perfusion during echocardiography. The product is indicated for patients undergoing stress echocardiography or resting echocardiography when acoustic visualization of the left ventricle is suboptimal.
Peak10.9 years to LOE
As a peak-stage diagnostic imaging agent with stable market position and no direct generic competition in sight, the brand team focuses on clinical adoption optimization and physician education rather than aggressive growth initiatives.
Mechanism of Action
Ultrasound Contrast Activity
Pharmacologic Class:
Contrast Agent for Ultrasound Imaging
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (6)
An Ascending Dose Comparison of MVT-100 to Definity in Healthy Volunteers
Started Apr 2019
16 enrolled
Heart Diseases
DEF-315 Better Accuracy in Ejection Fraction (EF) Assessment With DEFINITY
Started Dec 2018
160 enrolled
Cardiac Disease
DEF-314 Better Accuracy in Ejection Fraction (EF) Assessment With DEFINITY
Started Oct 2018
153 enrolled
Cardiac Disease
A Study of Commercial DEFINITY® to Monitor the Effects of the Heart's Pulmonary Artery Pressure
Started Jul 2009
32 enrolled
Pulmonary Heart Disease
Retrospective Safety Study to Compare Mortality in Intensive Care Unite (ICU) Patients Undergoing Echocardiography With or Without DEFINITY®
Started Jun 2008
4,300,000 enrolled
Cardiovascular Disease
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.