DECITABINE (decitabine) by Sagent Pharmaceuticals is methyltransferase, causing hypomethylation of dna and cellular differentiation or apoptosis. Approved for untreated, de novo, secondary mds of all french-american-british subtypes (refractory anemia and 9 more indications. First approved in 2018.
Drug data last refreshed 18h ago
methyltransferase, causing hypomethylation of DNA and cellular differentiation or apoptosis. Decitabine inhibits DNA methylation in vitro , which is achieved at concentrations that do not cause major suppression of DNA synthesis. Decitabine-induced hypomethylation in neoplastic cells may restore…
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