CLIMARA PRO
LOE Approachingestradiol; levonorgestrel
NDATRANSDERMALSYSTEM
Approved
Dec 2005
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
4/8 — Partial
CLIMARA PRO (estradiol; levonorgestrel) is characteristics. Approved for a woman with a uterus for: treatment of moderate to severe vasomotor symptoms due to menopause () prevention of postmenopausal osteoporosis () limitations of use:, first consider the use of non-estrogen medications, osteoporosis and 1 more indications. First approved in 2005.
Drug data last refreshed 2h ago · AI intelligence enriched 2h ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
CLIMARA PRO is a transdermal combination hormone replacement therapy (HRT) containing estradiol and levonorgestrel. It treats moderate to severe vasomotor symptoms (hot flashes) associated with menopause and prevents postmenopausal osteoporosis in women with an intact uterus. The estradiol component binds to estrogen receptors to reduce elevated gonadotropins and vasomotor symptoms, while levonorgestrel counteracts estrogen-induced endometrial proliferation.
$4.0MPart D
LOE ApproachingDeclining
Product is in late-stage lifecycle with moderate spending and claims volume; brand team faces imminent patent expiration and declining market opportunity.
Mechanism of Action
characteristics. Although circulating estrogens exist in a dynamic equilibrium of metabolic interconversions, estradiol is the principal intracellular human estrogen and is substantially more potent than its metabolites, estrone and estriol, at the receptor level. The primary source of estrogen in…
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.