NDAORALCAPSULE
Approved
Feb 1970
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
1
Data completeness
5/8 — Partial
CLEOCIN HYDROCHLORIDE (clindamycin hydrochloride) by Pfizer is mechanism of action clindamycin inhibits bacterial protein synthesis by binding to the 23s rna of the 50s subunit of the ribosome. Approved for acne. First approved in 1970.
Drug data last refreshed 20h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
CLEOCIN HYDROCHLORIDE (clindamycin HCl) is an oral antibiotic capsule that treats acne by inhibiting bacterial protein synthesis through binding to the 50S ribosomal subunit. As a bacteriostatic agent approved in 1970, it remains a foundational topical and systemic antimicrobial across multiple therapeutic areas.
LOE Approaching
As LOE approaches, brand teams will shift focus from growth initiatives to lifecycle extension strategies and cost-containment positioning against higher-priced isotretinoin competitors.
Mechanism of Action
Mechanism of Action Clindamycin inhibits bacterial protein synthesis by binding to the 23S RNA of the 50S subunit of the ribosome. Clindamycin is bacteriostatic.
Indications (1)
Clinical Trials (1)
Compound Adapalene and Clindamycin Hydrochloride Gel in Treatment of Patients With Acne
Started Mar 2015
245 enrolled
Acne
Career Relevance
Working on CLEOCIN HCl in a LOE-approaching environment prioritizes cost-containment expertise, defensive market positioning, and customer relationship management over launch-phase growth skills. Roles will increasingly focus on protecting market share against generics and isotretinoin competitors through payer negotiations, clinical evidence synthesis, and physician education.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.