Acne

12
Pipeline Programs
8
Companies
22
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
5
1
1
0
3
2
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 21 programs with unclassified modality

Competitive Landscape

7 companies ranked by most advanced pipeline stage

GSK
GSKLONDON, United Kingdom
3 programs
1
2
Benzoyl peroxide with clindamycinPhase 41 trial
DuacPhase 41 trial
TalarozolePhase 2Small Molecule1 trial
Active Trials
NCT00725439Completed16Est. Dec 2007
NCT00837213Completed33Est. Aug 2008
NCT00841776Completed54Est. Jan 2009
Bausch Health
Bausch HealthQUEBEC, Quebec, Canada
7 programs
4
3
ACYCPhase 31 trial
IDP 121 LotionPhase 31 trial
IDP-121 LotionPhase 31 trial
IDP-120 GelPhase 11 trial
IDP-121 LotionPhase 11 trial
+2 more programs
Active Trials
NCT02850003CompletedEst. Nov 2016
NCT02849860CompletedEst. Oct 2016
NCT02849873CompletedEst. Jan 2017
+4 more trials
LP
Lee's PharmaceuticalChina - Guangzhou
1 program
1
Adapalene + Clindamycin HydrochloridePhase 1/21 trial
Active Trials
NCT02593383Completed245Est. Jul 2017
Sagimet Biosciences
Sagimet BiosciencesCA - San Mateo
1 program
1
TVB-3567Phase 11 trial
Active Trials
NCT06989840RecruitingEst. Jun 2026
Pierre Fabre
Pierre FabreFrance - Aignan
8 programs
Biometrological measurementsN/A1 trial
Cosmetic productN/A1 trial
RV3278A - ET0943 cosmetic productN/A1 trial
RV3278B-OS0386N/A1 trial
RV4857AN/A1 trial
+3 more programs
Active Trials
NCT06841393Terminated50Est. Jan 2024
NCT04873089Completed37Est. Dec 2018
NCT05640388Completed41Est. Jan 2022
+5 more trials
Lumenis
LumenisAustralia - Chatswood
1 program
M22-IPLN/A1 trial
Active Trials
NCT02180282Terminated13Est. Dec 2015
Sanofi
SanofiPARIS, France
1 program
Non-interventional Translational Study in Mild, Moderate and Severe Acne PatientsN/A1 trial
Active Trials
NCT07411638Not Yet Recruiting200Est. Feb 2029

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
GSKDuac
GSKBenzoyl peroxide with clindamycin
Bausch HealthIDP 121 Lotion
Bausch HealthIDP-121 Lotion
Bausch HealthACYC
GSKTalarozole
Lee's PharmaceuticalAdapalene + Clindamycin Hydrochloride
Sagimet BiosciencesTVB-3567
Bausch Healthclindamycin phosphate 1.2%/adapalene 0.15%/BPO 3.1% gel
Bausch HealthIDP-120 Gel
Bausch HealthIDP-123 Lotion
Bausch HealthIDP-121 Lotion
SanofiNon-interventional Translational Study in Mild, Moderate and Severe Acne Patients
Pierre FabreTest product RV3278BB-OS0386
Pierre FabreRV3278B-OS0386

Showing 15 of 22 trials with date data

Clinical Trials (22)

Total enrollment: 1,158 patients across 22 trials

Comparative Antimicrobial Efficacy of Two Topical Acne Therapies for the Treatment of Facial Acne

Start: Aug 2007Est. completion: Jan 200954 patients
Phase 4Completed
NCT00837213GSKBenzoyl peroxide with clindamycin

Comparative Efficacy and Safety of Benzoyl Peroxide Used in Combination With Clindamycin vs. Benzoyl Peroxide Used in Combination With Clindamycin and Doxycycline in the Treatment of Moderate Acne

Start: Aug 2007Est. completion: Aug 200833 patients
Phase 4Completed

Efficacy and Safety of IDP-121 and IDP-121 Vehicle Lotion in the Treatment of Acne Vulgaris

Start: Nov 2015Est. completion: Feb 2017
Phase 3Completed

Efficacy and Safety of IDP-121 and IDP-121 Vehicle Lotion in the Treatment of Acne Vulgaris

Start: Nov 2015Est. completion: Feb 2017
Phase 3Completed

Clinical Study to Test the Efficacy and Safety of ACYC to Treat Moderate to Severe Acne

Start: Oct 2012Est. completion: Jul 2013
Phase 3Completed
NCT00725439GSKTalarozole

An Open Label Trial to Assess the Safety and Efficacy of Oral R115866 in the Treatment Facial Acne

Start: Sep 2004Est. completion: Dec 200716 patients
Phase 2Completed
NCT02593383Lee's PharmaceuticalAdapalene + Clindamycin Hydrochloride

Compound Adapalene and Clindamycin Hydrochloride Gel in Treatment of Patients With Acne

Start: Mar 2015Est. completion: Jul 2017245 patients
Phase 1/2Completed

Phase 1 Study to Evaluate the Safety, Tolerability, PK, and PD of TVB-3567 in Healthy Participants With or Without Acne

Start: Jun 2025Est. completion: Jun 2026
Phase 1Recruiting
NCT05582434Bausch Healthclindamycin phosphate 1.2%/adapalene 0.15%/BPO 3.1% gel

Experience With Topical Acne Treatment

Start: Feb 2024Est. completion: Nov 2026
Phase 1Active Not Recruiting

Absorption and Systematic Pharmacokinetics of Topically Applied IDP-120 Gel

Start: Jun 2016Est. completion: Nov 2016
Phase 1Completed

Absorption and Systematic Pharmacokinetics of IDP-123 Lotion in Comparison With Tazorac Cream

Start: Jun 2016Est. completion: Jan 2017
Phase 1Completed

Absorption and Systematic Pharmacokinetics of IDP-121 Lotion in Subjects With Acne Vulgaris

Start: Feb 2014Est. completion: Oct 2016
Phase 1Completed
NCT07411638SanofiNon-interventional Translational Study in Mild, Moderate and Severe Acne Patients

Non-interventional Translational Study in Mild, Moderate and Severe Acne Patients

Start: Feb 2026Est. completion: Feb 2029200 patients
N/ANot Yet Recruiting
NCT07341659Pierre FabreTest product RV3278BB-OS0386

Efficacy of Cosmetic Product RV3278B-OS0386 in the Maintenance Phase After Oral Isotretinoin Treatment of Adults Subjects With Facial Acne.

Start: Feb 2025Est. completion: Sep 2026102 patients
N/AActive Not Recruiting

Efficacy of Cosmetic Product RV3278B-OS0386 on Skin Surface Ecosystem, in Teenagers with Mild to Moderate Facial Acne

Start: Oct 2024Est. completion: Mar 202552 patients
N/ACompleted

A Comparative Study of Cosmetic Product in Subjects With Facial Acne During an Associated-treatment Phase Followed by a Maintenance Phase

Start: Jul 2024Est. completion: Jul 202560 patients
N/ARecruiting
NCT06841393Pierre FabreBiometrological measurements

Assessment of Biological, Biometrological Parameters and Consumer Needs in Adult Subjects with Acne

Start: Oct 2023Est. completion: Jan 202450 patients
N/ATerminated
NCT05640388Pierre FabreRV3278A - ET0943 cosmetic product

Assessment of a Cosmetic Product Effect on the Host/Microorganism Relationship in Acneic Subjects

Start: Sep 2021Est. completion: Jan 202241 patients
N/ACompleted

Sunscreen Efficacy Against the Reccurence of Lesions Post-sun Exposure in Acneic Subjects

Start: Jul 2020Est. completion: Nov 202045 patients
N/ACompleted

Use of the SpiderMass for in Vivo Analysis of the Skin in Five Chronic Inflammatory Dermatosis

Start: Dec 2019Est. completion: Feb 2024210 patients
N/ACompleted
NCT04873089Pierre FabreCosmetic product

Efficacy Study of Cosmetic Product RV3278AET0943 Versus Non-treated Group in Adults With Oily and Acne Prone Skin

Start: Sep 2018Est. completion: Dec 201837 patients
N/ACompleted

Impact of the M22-IPL Acne Filter on Acne Vulgaris

Start: Jul 2014Est. completion: Dec 201513 patients
N/ATerminated

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

3 late-stage (Phase 3) programs — potential near-term approvals
2 actively recruiting trials targeting 1,158 patients
8 companies competing in this space