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Acne

18
Pipeline Programs
17
Companies
50
Clinical Trials
4 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
1
3
0
5
6
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
2100%
+ 36 programs with unclassified modality

Competitive Landscape

15 companies ranked by most advanced pipeline stage

Galderma
GaldermaTX - Dallas
11 programs
1
2
3
4
Adapalene/BPO GelPhase 41 trial
More frequent than normal office visitsPhase 41 trial
Product APhase 41 trial
adapalene/benzoyl peroxidePhase 41 trial
Adapalene 0.1% / Benzoyl Peroxide 2.5% GelPhase 31 trial
+6 more programs
Active Trials
NCT01220102Completed3,113Est. Nov 2010
NCT01688531Completed38Est. Sep 2013
NCT03034460Completed70Est. Nov 2016
+8 more trials
ViiV Healthcare
ViiV HealthcareNC - Durham
3 programs
1
2
Benzoyl peroxide with clindamycinPhase 4
DuacPhase 4
TalarozolePhase 2Small Molecule
Bausch Health
Bausch HealthQUEBEC, Quebec, Canada
3 programs
1
2
ACYCPhase 31 trial
IDP-121Phase 33 trials
clindamycin phosphate 1.2%/adapalene 0.15%/BPO 3.1% gelPhase 11 trial
Active Trials
NCT05582434Active Not Recruiting72Est. Nov 2026
NCT01701024Completed498Est. Jul 2013
NCT02965456Completed820Est. Feb 2017
+2 more trials
Prevail Therapeutics
1 program
1
LemuteporfinPhase 1/2
Vyne Therapeutics
Vyne TherapeuticsIsrael - Ness Ziona
1 program
1
FMX101, Minocycline 4% foamPhase 11 trial
Active Trials
NCT02250859Completed12Est. Jan 2015
Pierre Fabre
Pierre FabreFrance - Aignan
8 programs
Biometrological measurementsN/A1 trial
Cosmetic productN/A1 trial
RV3278A - ET0943 cosmetic productN/A1 trial
RV3278B-OS0386N/A1 trial
RV4857AN/A1 trial
+3 more programs
Active Trials
NCT06841393Terminated50Est. Jan 2024
NCT04873089Completed37Est. Dec 2018
NCT05640388Completed41Est. Jan 2022
+5 more trials
GSK
GSKLONDON, United Kingdom
3 programs
TalarozolePHASE_2Small Molecule1 trial
Benzoyl peroxide with clindamycinPHASE_41 trial
DuacPHASE_41 trial
Active Trials
NCT00725439Completed16Est. Dec 2007
NCT00837213Completed33Est. Aug 2008
NCT00841776Completed54Est. Jan 2009
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
1 program
BEAM deviceN/A1 trial
Active Trials
NCT01162837Completed33Est. Oct 2010
Lumenis
LumenisAustralia - Chatswood
1 program
M22-IPLN/A1 trial
Active Trials
NCT02180282Terminated13Est. Dec 2015
Sanofi
SanofiPARIS, France
1 program
Non-interventional Translational Study in Mild, Moderate and Severe Acne PatientsN/A1 trial
Active Trials
NCT07411638Not Yet Recruiting200Est. Feb 2029
STRATA Skin Sciences
1 program
TheraClearXN/A1 trial
Active Trials
NCT06043102Completed30Est. Sep 2023
Bayer
BayerLEVERKUSEN, Germany
1 program
treatment azelaic acidN/A1 trial
Active Trials
NCT01850095Unknown60Est. Jan 2015
Sagimet Biosciences
Sagimet BiosciencesCA - San Mateo
1 program
TVB-3567PHASE_11 trial
Active Trials
NCT06989840Recruiting128Est. Jun 2026
Lee's Pharmaceutical
Lee's PharmaceuticalChina - Guangzhou
1 program
Adapalene + Clindamycin HydrochloridePHASE_1_21 trial
Active Trials
NCT02593383Completed245Est. Jul 2017
Bristol Myers Squibb
1 program
apremilastPHASE_25 trials
Active Trials
NCT06382987Recruiting600Est. Dec 2029
NCT05744466Recruiting1,500Est. Dec 2027
NCT04908189Active Not Recruiting729Est. Nov 2026
+2 more trials

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
Bristol Myers Squibbapremilast
GaldermaProduct A
Bristol Myers Squibbapremilast
GaldermaAdapalene/BPO Gel
Galdermaadapalene/benzoyl peroxide
GSKBenzoyl peroxide with clindamycin
GSKDuac
GaldermaMore frequent than normal office visits
Bristol Myers Squibbapremilast
Bristol Myers Squibbapremilast
Bristol Myers Squibbapremilast
Bristol Myers Squibbapremilast
Bausch HealthIDP-121
Bausch HealthIDP-121
Bausch HealthACYC

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 9,853 patients across 50 trials

Validation of the PsASon ULtrasound Scores in Patients With Psoriatic Arthritis Undergoing TReatment With Apremilast

Start: Jul 2020Est. completion: Feb 20220
Phase 4Withdrawn

A Clinical Trial to Evaluate the Efficacy of Two Acne Treatments

Start: May 2016Est. completion: Apr 2017127 patients
Phase 4Completed

Apremilast in Palmo-Plantar Psoriasis

Start: May 2015Est. completion: Nov 2016100 patients
Phase 4Completed
NCT01951417GaldermaAdapalene/BPO Gel

Adapalene BPO Gel Pump, Moisturizer SPF 30 and Foam Wash in Patients With Mild to Moderate Acne Vulgaris

Start: Oct 2013Est. completion: Mar 201481 patients
Phase 4Completed
NCT01138735Galdermaadapalene/benzoyl peroxide

Epiduo Pediatric Acne Study

Start: Jun 2010Est. completion: Aug 2011285 patients
Phase 4Completed
NCT00837213GSKBenzoyl peroxide with clindamycin

Comparative Efficacy and Safety of Benzoyl Peroxide Used in Combination With Clindamycin vs. Benzoyl Peroxide Used in Combination With Clindamycin and Doxycycline in the Treatment of Moderate Acne

Start: Aug 2007Est. completion: Aug 200833 patients
Phase 4Completed

Comparative Antimicrobial Efficacy of Two Topical Acne Therapies for the Treatment of Facial Acne

Start: Aug 2007Est. completion: Jan 200954 patients
Phase 4Completed
NCT00437151GaldermaMore frequent than normal office visits

Analysis of Adherence & Associated Factors in Teenagers Undergoing Treatment of Acne Vulgaris With Differin® Gel 0.1%

Start: Jun 2006Est. completion: Jun 200761 patients
Phase 4Completed

A Study to Determine the Efficacy and Safety of Deucravacitinib Compared With Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Are Naïve to Biologic Disease Modifying Anti-rheumatic Drugs or Had Previously Received TNFα Inhibitor Treatment

Start: Jul 2021Est. completion: Nov 2026729 patients
Phase 3Active Not Recruiting

Effectiveness and Safety of BMS-986165 Compared to Placebo and Active Comparator in Participants With Psoriasis

Start: Aug 2018Est. completion: Sep 2020666 patients
Phase 3Completed

An Investigational Study to Evaluate Experimental Medication BMS-986165 Compared to Placebo and a Currently Available Treatment in Participants With Moderate-to-Severe Plaque Psoriasis

Start: Jul 2018Est. completion: Nov 20201,020 patients
Phase 3Completed

Assessment of the Clinical and Ultrasound Response to Apremilast by Clinical Evaluation and by a Joint-periarticular-nail Ultrasound Index in Patients With Active Psoriatic Arthritis

Start: Nov 2017Est. completion: Jun 201956 patients
Phase 3Unknown

Efficacy and Safety of IDP-121 and IDP-121 Vehicle Lotion in the Treatment of Acne Vulgaris

Start: Nov 2015Est. completion: Feb 2017820 patients
Phase 3Completed

Efficacy and Safety of IDP-121 and IDP-121 Vehicle Lotion in the Treatment of Acne Vulgaris

Start: Nov 2015Est. completion: Feb 2017820 patients
Phase 3Completed

Clinical Study to Test the Efficacy and Safety of ACYC to Treat Moderate to Severe Acne

Start: Oct 2012Est. completion: Jul 2013498 patients
Phase 3Completed
NCT01474590GaldermaEpiduo/Tactuo

Efficacy & Safety Comparison of Epiduo With Doxycycline Versus Vehicle With Isotretinoin in the Treatment of Severe Acne

Start: Nov 2011Est. completion: Aug 2013266 patients
Phase 3Completed
NCT00883233GaldermaAdapalene BPO Gel standard daily overnight application

Comparison of Four Different Regimens of Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel in Acne Vulgaris

Start: Apr 2009Est. completion: Sep 2009123 patients
Phase 3Completed
NCT00687908GaldermaAdapalene 0.1% / Benzoyl Peroxide 2.5% Gel

Adapalene-Benzoy Peroxide (BPO) Gel in the Treatment of Acne Vulgaris as a 6-month Maintenance

Start: Nov 2008Est. completion: Jul 2009243 patients
Phase 3Completed

Apremilast - Oral Lichen Planus Trial

Start: Nov 2019Est. completion: Apr 20200
Phase 2Withdrawn

The AP-GELP Study: A Clinical Trial on the Effects of Apremilast in Female Genital Erosive Lichen Planus

Start: Sep 2019Est. completion: Dec 202342 patients
Phase 2Unknown

An Investigator-initiated Study of Apremilast to Demonstrate Efficacy Nummular Eczema

Start: Jul 2017Est. completion: Sep 202131 patients
Phase 2Completed

Short-term Safety, Efficacy and Mode of Action of Apremilast in Moderate Suppurative Hidradenitis

Start: Feb 2017Est. completion: Jun 201820 patients
Phase 2Completed
NCT03034460GaldermaCD5024 1% cream

Efficacy and Safety of CD5024 1% in Acne Vulgaris

Start: Apr 2016Est. completion: Nov 201670 patients
Phase 2Completed

Concomitant Use of Apremilast for the Treatment of Active RA Despite TNF-Inhibition and Methotrexate- CATARA

Start: Sep 2010Est. completion: Dec 20110
Phase 2Withdrawn

Efficacy Study of Apremilast (CC-10004) in Subjects With Erosive Hand Osteoarthritis

Start: Aug 2010Est. completion: Oct 201330 patients
Phase 2Completed
NCT01106807GaldermaEpiduo vehicle gel

Exploratory Study to Evaluate the Efficacy and Safety of CD07223 Gel in Subjects With Acne

Start: Apr 2010Est. completion: Sep 201073 patients
Phase 2Completed

Apremilast in the Treatment of Moderate to Severe Acne

Start: Feb 2010Est. completion: Oct 20103 patients
Phase 2Terminated

Spondylitis Trial of Apremilast for Better Rheumatic Therapy

Start: Aug 2009Est. completion: Jan 201138 patients
Phase 2Completed
NCT00725439GSKTalarozole

An Open Label Trial to Assess the Safety and Efficacy of Oral R115866 in the Treatment Facial Acne

Start: Sep 2004Est. completion: Dec 200716 patients
Phase 2Completed
NCT02593383Lee's PharmaceuticalAdapalene + Clindamycin Hydrochloride

Compound Adapalene and Clindamycin Hydrochloride Gel in Treatment of Patients With Acne

Start: Mar 2015Est. completion: Jul 2017245 patients
Phase 1/2Completed

Phase 1 Study to Evaluate the Safety, Tolerability, PK, and PD of TVB-3567 in Healthy Participants With or Without Acne

Start: Jun 2025Est. completion: Jun 2026128 patients
Phase 1Recruiting
NCT05582434Bausch Healthclindamycin phosphate 1.2%/adapalene 0.15%/BPO 3.1% gel

Experience With Topical Acne Treatment

Start: Feb 2024Est. completion: Nov 202672 patients
Phase 1Active Not Recruiting
NCT02250859Vyne TherapeuticsFMX101, Minocycline 4% foam

A Pharmacokinetic Study of Minocycline in Male and Female Volunteers

Start: Sep 2014Est. completion: Jan 201512 patients
Phase 1Completed

Absorption and Systematic Pharmacokinetics of IDP-121 Lotion in Subjects With Acne Vulgaris

Start: Feb 2014Est. completion: Oct 201620 patients
Phase 1Completed
NCT01688531GaldermaCD0271 0.1%/CD1579 2.5% gel

A Pilot Study to Investigate Filiation Between Primary and Secondary Lesions in Acne Patients

Start: Aug 2012Est. completion: Sep 201338 patients
Phase 1Completed
NCT07411638SanofiNon-interventional Translational Study in Mild, Moderate and Severe Acne Patients

Non-interventional Translational Study in Mild, Moderate and Severe Acne Patients

Start: Feb 2026Est. completion: Feb 2029200 patients
N/ANot Yet Recruiting
NCT07341659Pierre FabreTest product RV3278BB-OS0386

Efficacy of Cosmetic Product RV3278B-OS0386 in the Maintenance Phase After Oral Isotretinoin Treatment of Adults Subjects With Facial Acne.

Start: Feb 2025Est. completion: Sep 2026102 patients
N/AActive Not Recruiting

Efficacy of Cosmetic Product RV3278B-OS0386 on Skin Surface Ecosystem, in Teenagers with Mild to Moderate Facial Acne

Start: Oct 2024Est. completion: Mar 202552 patients
N/ACompleted

A Comparative Study of Cosmetic Product in Subjects With Facial Acne During an Associated-treatment Phase Followed by a Maintenance Phase

Start: Jul 2024Est. completion: Jul 202560 patients
N/ARecruiting

A Study of the Comparative Effectiveness of Deucravacitinib in Adults With Plaque Psoriasis in Japan (RePhlect)

Start: Jan 2024Est. completion: Dec 2029600 patients
N/ARecruiting
NCT06841393Pierre FabreBiometrological measurements

Assessment of Biological, Biometrological Parameters and Consumer Needs in Adult Subjects with Acne

Start: Oct 2023Est. completion: Jan 202450 patients
N/ATerminated

Study Evaluating the Efficacy and Safety of TheraClearX on Mitigating Mild to Moderate Acne

Start: May 2023Est. completion: Sep 202330 patients
N/ACompleted

A Real-world Observational Study to Compare Effectiveness of Deucravacitinib Vs Apremilast in Adults With Plaque Psoriasis

Start: Sep 2022Est. completion: Dec 20271,500 patients
N/ARecruiting
NCT05640388Pierre FabreRV3278A - ET0943 cosmetic product

Assessment of a Cosmetic Product Effect on the Host/Microorganism Relationship in Acneic Subjects

Start: Sep 2021Est. completion: Jan 202241 patients
N/ACompleted

Sunscreen Efficacy Against the Reccurence of Lesions Post-sun Exposure in Acneic Subjects

Start: Jul 2020Est. completion: Nov 202045 patients
N/ACompleted

Use of the SpiderMass for in Vivo Analysis of the Skin in Five Chronic Inflammatory Dermatosis

Start: Dec 2019Est. completion: Feb 2024210 patients
N/ACompleted
NCT04873089Pierre FabreCosmetic product

Efficacy Study of Cosmetic Product RV3278AET0943 Versus Non-treated Group in Adults With Oily and Acne Prone Skin

Start: Sep 2018Est. completion: Dec 201837 patients
N/ACompleted

Impact of the M22-IPL Acne Filter on Acne Vulgaris

Start: Jul 2014Est. completion: Dec 201513 patients
N/ATerminated
NCT01850095Bayertreatment azelaic acid

The Influence of Peripheral Androgen Conversion at Women Adult Acne

Start: Mar 2012Est. completion: Jan 201560 patients
N/AUnknown

Safety & Effectiveness of the BEAM Device in Mild-to-moderate Acne

Start: Jun 2010Est. completion: Oct 201033 patients
N/ACompleted

Related Jobs

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

5 late-stage (Phase 3) programs, potential near-term approvals
4 actively recruiting trials targeting 9,853 patients
17 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.