NDAORALSYRUPPriority Review
Approved
Sep 2004
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
14
Data completeness
5/8 — Partial
Priority Review
CLARINEX (desloratadine) by Merck & Co. is 1 -receptor histamine antagonist activity. Approved for seasonal allergic rhinitis, chronic idiopathic urticaria. First approved in 2004.
Drug data last refreshed 22h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Clarinex (desloratadine) is a selective H1-receptor antagonist approved for seasonal allergic rhinitis, chronic idiopathic urticaria, and other allergic conditions. It works by blocking histamine-mediated allergic responses without significant central nervous system penetration. The oral syrup formulation enables convenient dosing across adult and pediatric populations.
$0.289MPart D
LOE ApproachingDeclining
Product approaching loss of exclusivity with minimal Part D spending; brand team likely focused on managed care and generic transition strategy.
Mechanism of Action
1 -receptor histamine antagonist activity. Receptor binding data indicate that at a concentration of 2 to 3 ng/mL (7 nanomolar), desloratadine shows significant interaction with the human histamine H 1 receptor. Desloratadine inhibited histamine release from human mast cells in vitro . Results of a…
Indications (2)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.