Seasonal Allergic Rhinitis

32
Pipeline Programs
10
Companies
27
Clinical Trials
7
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
2
12
0
5
12
Early DiscoveryClinical DevelopmentMarket

On Market (7)

Approved therapies currently available

Teva
AZELASTINE HYDROCHLORIDE AND FLUTICASONE PROPIONATEApproved
azelastine hydrochloride and fluticasone propionate
Teva
nasal2025
U
BECLOMETHASONE DIPROPIONATEApproved
beclomethasone dipropionate
Unknown Company
inhalation2025
U
CHILDREN'S FEXOFENADINE HYDROCHLORIDE HIVESApproved
fexofenadine hcl
Unknown Company
oral2014
U
LEVOCETIRIZINE DIHYDROCHLORIDEApproved
levocetirizine dihydrochloride
Unknown Company
oral2016
Teva
QNASLApproved
beclomethasone dipropionate
Teva
nasal2012
Teva
QVAR 40Approved
beclomethasone dipropionate
Teva
inhalation2000
Teva
QVAR 80Approved
beclomethasone dipropionate
Teva
inhalation2000

Competitive Landscape

10 companies ranked by most advanced pipeline stage

UP
UCB PharmaBelgium - Brussels
5 programs
4
1 week of treatment discontinuationPhase 41 trial
LevocetirizinePhase 41 trial
levocetirizine dihydrochloridePhase 41 trial
levocetirizine dihydrochloridePhase 41 trial
NACN/A1 trial
Active Trials
NCT03450031Completed24Est. Oct 2018
NCT00223587Terminated22Est. Jan 2008
NCT00160537Completed200Est. Jul 2005
+2 more trials
Teva
TevaIsrael - Petach Tikva
5 programs
1
1
3
1
Azelastine hydrochloride and Fluticasone propionatePhase 31 trial
BDP HFAPhase 31 trial
Beclomethasone dipropionatePhase 31 trial
Beclomethasone dipropionate HFA Nasal AerosolPhase 21 trial
Mometasone furoatePhase 1/21 trial
Active Trials
NCT01523236Completed800Est. Jan 2012
NCT00854360Completed487Est. May 2009
NCT02249663Unknown1,535
+2 more trials
Sanofi
SanofiPARIS, France
1 program
1
Fexofenadine HClPhase 41 trial
Active Trials
NCT00637611Completed1,010Est. Apr 2003
Faes Farma
Faes FarmaSpain - Leioa
5 programs
3
2
BilastinePhase 31 trial
bilastinePhase 31 trial
BilastinePhase 21 trial
BilastinePhase 21 trial
BilastinePhase 21 trial
Active Trials
NCT00574379Completed805Est. Mar 2008
NCT00574210Completed502Est. Feb 2008
NCT00420082Completed75Est. Dec 2006
+2 more trials
Bausch + Lomb
Bausch + LombNJ - Bridgewater
4 programs
1
3
Bepotastine Besilate Nasal Spray 2% Twice a dayPhase 21 trial
Bepotastine besilatePhase 21 trial
Bepotastine besilate formulationPhase 21 trial
bepotastine besilate nasal product - low dosePhase 1/21 trial
Active Trials
NCT01222299Completed89Est. Aug 2010
NCT01277341Completed601Est. May 2011
NCT01753739Completed617Est. May 2013
+1 more trials
CT
3 programs
3
TQC2938 injectionPhase 21 trial
TQH2722 injectionPhase 21 trial
TQH2722 injectionPhase 21 trial
Active Trials
NCT07052097CompletedEst. Nov 2025
NCT07398859Not Yet RecruitingEst. Mar 2027
NCT06760182CompletedEst. Jul 2025
M&
Merck & Co.RAHWAY, NJ
1 program
1
Epinastine Nasal SprayPhase 21 trial
Active Trials
NCT00407927Completed571Est. Mar 2007
Revolo Biotherapeutics
1 program
1
IRL201104Phase 21 trial
Active Trials
NCT05098522Completed63Est. Mar 2023
Stallergenes Greer
Stallergenes GreerFrance - Antony
1 program
1
300 IR grass pollen allergen extract tabletPhase 11 trial
Active Trials
NCT00619827Completed89Est. Mar 2008
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
1 program
Fluticasone propionateN/A1 trial
Active Trials
NCT00755066Completed

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
UCB Pharmalevocetirizine dihydrochloride
UCB Pharmalevocetirizine dihydrochloride
UCB PharmaLevocetirizine
UCB Pharma1 week of treatment discontinuation
SanofiFexofenadine HCl
TevaAzelastine hydrochloride and Fluticasone propionate
TevaBDP HFA
TevaBeclomethasone dipropionate
Faes Farmabilastine
Faes FarmaBilastine
Chia Tai TianQing Pharmaceutical GroupTQH2722 injection
Chia Tai TianQing Pharmaceutical GroupTQC2938 injection
Chia Tai TianQing Pharmaceutical GroupTQH2722 injection
Revolo BiotherapeuticsIRL201104
Bausch + LombBepotastine besilate

Showing 15 of 26 trials with date data

Clinical Trials (27)

Total enrollment: 11,730 patients across 27 trials

NCT00653224UCB Pharmalevocetirizine dihydrochloride

A Study Evaluating the Efficacy and Impact on Health-related Quality of Life of Levocetirizine in Adults With Seasonal Allergic Rhinitis

Start: Apr 2008Est. completion: Jul 2008580 patients
Phase 4Completed
NCT00621959UCB Pharmalevocetirizine dihydrochloride

A Study Evaluating the Efficacy and Impact on Health-related Quality of Life of Levocetirizine in Adults With Seasonal Allergic Rhinitis

Start: Mar 2008Est. completion: Jun 2008596 patients
Phase 4Completed
NCT00160537UCB PharmaLevocetirizine

POPULAR (Preference Of Patient Using Levocetirizine in Allergic Rhinitis)

Start: May 2005Est. completion: Jul 2005200 patients
Phase 4Completed
NCT00223587UCB Pharma1 week of treatment discontinuation

Seasonal Allergic Rhinitis and Driving Ability

Start: Sep 2004Est. completion: Jan 200822 patients
Phase 4Terminated
NCT00637611SanofiFexofenadine HCl

Single-Center, Double-Blind, Randomized , Parallel Study Comparing Onset of Action, Efficacy & Safety of a Single-Dose of Fexofenadine HCl 180 mg vs Montelukast Na 10 mg & Placebo in Treating Seasonal Allergic Rhinitis Subjects in an Allergen Exposure Unit

Start: Feb 2003Est. completion: Apr 20031,010 patients
Phase 4Completed
NCT02249663TevaAzelastine hydrochloride and Fluticasone propionate

Clinical Equivalence of Azelastine Hydrochloride and Fluticasone Propionate, 137/50 mcg Nasal Spray to Dymista™

Start: Aug 20141,535 patients
Phase 3Unknown

Study of an Investigational Nasal Aerosol or Placebo Nasal Aerosol in Children (Ages 6-11) With Seasonal Allergies

Start: Mar 2011Est. completion: Aug 2011715 patients
Phase 3Completed
NCT01024608TevaBeclomethasone dipropionate

Study in Adult and Adolescent Subjects With Seasonal Allergic Rhinitis (SAR)

Start: Dec 2009Est. completion: Feb 2010340 patients
Phase 3Completed

Efficacy Study for the Symptomatic Treatment of Seasonal Allergic Rhinitis

Start: May 2005Est. completion: Nov 2005683 patients
Phase 3Completed

A Phase III Efficacy Study of the Symptomatic Treatment of Seasonal Allergic Rhinitis With Bilastine

Start: Apr 2003Est. completion: Feb 2004720 patients
Phase 3Completed

Clinical Study on TQH2722 Injection Combined With Background Therapy for Seasonal Allergic Rhinitis

Start: Mar 2026Est. completion: Mar 2027
Phase 2Not Yet Recruiting

Clinical Trial of TQC2938 Injection in Patients With Seasonal Allergic Rhinitis

Start: Jul 2025Est. completion: Nov 2025
Phase 2Completed

Clinical Trial of TQH2722 Injection in Patients With Seasonal Allergic Rhinitis

Start: Mar 2025Est. completion: Jul 2025
Phase 2Completed

Allergen Challenge Trial of IRL201104 in Seasonal Allergic Rhinitis

Start: Nov 2021Est. completion: Mar 202363 patients
Phase 2Completed
NCT01753739Bausch + LombBepotastine besilate

Bepotastine Besilate Nasal Sprays in the Treatment of Seasonal Allergic Rhinitis (SAR)

Start: Jan 2013Est. completion: May 2013617 patients
Phase 2Completed
NCT01578278Bausch + LombBepotastine besilate formulation

Bepotastine Besilate-corticosteroid Nasal Spray Combination Compared to Placebo, Bepotastine Besilate Nasal Spray, and Corticosteroid Nasal Spray in the Treatment of Patients With Seasonal Allergic Rhinitis

Start: Dec 2011Est. completion: Aug 2012606 patients
Phase 2Completed
NCT01277341Bausch + LombBepotastine Besilate Nasal Spray 2% Twice a day

Safety and Efficacy of Bepotastine Besilate Nasal Spray in the Treatment of Seasonal Allergic Rhinitis

Start: Dec 2010Est. completion: May 2011601 patients
Phase 2Completed
NCT00854360TevaBeclomethasone dipropionate HFA Nasal Aerosol

Study to Assess the Efficacy and Safety of BDP HFA Nasal Aerosol in Patients 12 Years and Older With SAR

Start: Mar 2009Est. completion: May 2009487 patients
Phase 2Completed

Efficacy, Safety and PK of Once or Twice Daily Bilastine (10 or 20 mg) Compared With Placebo in the Symptomatic Treatment of SAR

Start: Dec 2007Est. completion: Mar 2008805 patients
Phase 2Completed

PK/PD and Steady State Efficacy Study of Bilastine Compared With Placebo Given Orally in the Treatment of the Symptoms of SAR in an EEC Model (5-arm)

Start: Oct 2007Est. completion: Feb 2008502 patients
Phase 2Completed
NCT00407927Merck & Co.Epinastine Nasal Spray

A Study of Epinastine Nasal Spray in Subjects With Seasonal Allergic Rhinitis

Start: Dec 2006Est. completion: Mar 2007571 patients
Phase 2Completed

A Randomized, Double-Blind, 4-way Crossover Study to Evaluate the Efficacy of Bilastine in the Vienna Challenge Chamber

Start: Oct 2006Est. completion: Dec 200675 patients
Phase 2Completed
NCT01523236TevaMometasone furoate

Clinical Equivalence Study of Mometasone Nasal Spray, 50 Mcg/Actuation

Start: Dec 2011Est. completion: Jan 2012800 patients
Phase 1/2Completed
NCT01222299Bausch + Lombbepotastine besilate nasal product - low dose

Safety, Pharmacokinetics, and Efficacy of Bepotastine Besilate Nasal Product After Ragweed Pollen Exposure in an Environmental Chamber

Start: May 2010Est. completion: Aug 201089 patients
Phase 1/2Completed
NCT00619827Stallergenes Greer300 IR grass pollen allergen extract tablet

Efficacy and Safety of Sublingual Tablets of Grass Pollen Allergen Extract

Start: Sep 2007Est. completion: Mar 200889 patients
Phase 1Completed
NCT00755066Allergy TherapeuticsFluticasone propionate

Effect of Intranasal Corticosteroids on Systemic Allergen Specific IgE

N/ACompleted

Evaluation of Nasal Inflammatory Biomarkers

Start: Feb 2018Est. completion: Oct 201824 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

5 late-stage (Phase 3) programs — potential near-term approvals
10 companies competing in this space