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Seasonal Allergic Rhinitis

58
Pipeline Programs
30
Companies
50
Clinical Trials
1 recruiting
9
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
3
21
0
13
19
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
150%
Monoclonal Antibody
150%
+ 79 programs with unclassified modality

On Market (9)

Approved therapies currently available

GSK
ARNUITY ELLIPTAApproved
fluticasone furoate
GSK
inhalation2014
98M Part D
ALVESCOApproved
ciclesonide
Unknown Company
inhalation2008
35M Part D
OMNARISApproved
ciclesonide
Unknown Company
nasal2006
923K Part D
ZETONNAApproved
ciclesonide
Unknown Company
nasal2012
323K Part D
AstraZeneca
PULMICORTApproved
budesonide
AstraZeneca
inhalation1997
222K Part D
AstraZeneca
RHINOCORTApproved
budesonide
AstraZeneca
nasal1994
GSK
FLONASE SENSIMIST ALLERGY RELIEFApproved
fluticasone furoate
GSK
nasal2007
AstraZeneca
PULMICORT RESPULESApproved
budesonide
AstraZeneca
Corticosteroid [EPC]inhalation2000
MOMETASONE FUROATEApproved
mometasone
Unknown Company
nasal2017

Competitive Landscape

31 companies ranked by most advanced pipeline stage

ViiV Healthcare
ViiV HealthcareNC - Durham
6 programs
3
Fluticasone furoate Nasal Spray 110 mcgPhase 4
PL nasal sprayPhase 4
fluticasone furoatePhase 4
Biomarkers in Nasal Samples of Seasonal Allergic RhiniticsN/A
CetirizineN/A
+1 more programs
GSK
GSKLONDON, United Kingdom
5 programs
1
Biomarkers in Nasal Samples of Seasonal Allergic RhiniticsN/A1 trial
CetirizineN/A1 trial
pseudoephedrine hydrochlorideN/A1 trial
PL nasal sprayPHASE_41 trial
fluticasone furoatePHASE_41 trial
Active Trials
NCT04670627Completed92Est. Apr 2023
NCT00334698Completed51Est. Sep 2006
NCT00517946Completed21Est. Apr 2007
+2 more trials
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
5 programs
3
1
1
montelukastPhase 4
epinastine nasal spray, low concentration, low dose volumePhase 3
BilastinePhase 2
Epinastine Nasal SprayPhase 2
SCH 900538Phase 2
MSD
MSDIreland - Ballydine
5 programs
3
1
1
montelukastPhase 41 trial
epinastine nasal spray, low concentration, low dose volumePhase 31 trial
BilastinePhase 21 trial
Epinastine Nasal SprayPhase 21 trial
SCH 900538Phase 21 trial
Active Trials
NCT00574379Completed805Est. Mar 2008
NCT00407927Completed571Est. Mar 2007
NCT00673062Completed265Est. Jul 2008
+2 more trials
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
3 programs
1
2
1
BudesonidePhase 31 trial
CiclesonidePhase 31 trial
budesonidePhase 21 trial
Active Trials
NCT00641979Completed200Est. Aug 2002
NCT00641680Completed750Est. Jul 2003
NCT02155881Completed80Est. Nov 2014
Alcon
AlconFORT WORTH, TX
3 programs
1
2
Olopatadine HCL Nasal Spray, 0.6%Phase 41 trial
Olopatadine HCl Nasal Spray, 0.6%Phase 41 trial
Olopatadine Hydrochloride Nasal Spray 0.6%Phase 31 trial
Active Trials
NCT00578929Completed2,388
NCT00691665Completed130
NCT00845195Completed150
Bayer
BayerLEVERKUSEN, Germany
2 programs
1
1
Azelastine and placeboPhase 41 trial
PhenylephrinePhase 31 trial
Active Trials
NCT01413958Completed575Est. Oct 2011
NCT00561717Completed70Est. Feb 2008
Integrated Biosciences
Integrated BiosciencesCA - San Carlos
1 program
1
Mometasone Furoate Nasal SprayPhase 41 trial
Active Trials
NCT00358527Completed401Est. Nov 2006
Allergopharma
AllergopharmaGermany - Reinbek
1 program
1
grassPhase 41 trial
Active Trials
NCT01555736Completed120Est. Sep 2006
Sandoz
SandozAustria - Kundl
7 programs
1
1
2
3
Azelastine + Mometazone, nasal sprayPhase 3
MometasonePhase 3
OmalizumabPhase 3Monoclonal Antibody
QAV680Phase 2
VAK694; Alutard Avanz SQPhase 2
+2 more programs
Idorsia
IdorsiaSwitzerland - Allschwil
2 programs
1
1
ACT-129968Phase 31 trial
ACT-129968Phase 21 trial
Active Trials
NCT01241214Completed579Est. Feb 2011
NCT01484119Completed630Est. Mar 2012
Longbio Pharma
Longbio PharmaChina - Shanghai
2 programs
1
1
LP-003Phase 31 trial
LP-003 dose 1Phase 21 trial
Active Trials
NCT06046391Completed180Est. Aug 2024
NCT07291284Active Not Recruiting546Est. Dec 2026
Abbott
AbbottABBOTT PARK, IL
1 program
1
Phleum pratense grass pollen allergen extractPhase 31 trial
Active Trials
NCT02245360Completed107Est. Mar 2015
Biocorp
1 program
1
sublingual immunotherapy dropsPhase 31 trial
Active Trials
NCT03649139Completed71Est. Oct 2018
Bausch + Lomb
Bausch + LombNJ - Bridgewater
4 programs
1
3
Bepotastine Besilate Nasal Spray 2% Twice a dayPhase 2
Bepotastine besilatePhase 2
Bepotastine besilate formulationPhase 2
bepotastine besilate nasal product - low dosePhase 1/2
Bausch Health
Bausch HealthQUEBEC, Quebec, Canada
4 programs
1
3
Bepotastine Besilate Nasal Spray 2% Twice a dayPhase 21 trial
Bepotastine besilatePhase 21 trial
Bepotastine besilate formulationPhase 21 trial
bepotastine besilate nasal product - low dosePhase 1/21 trial
Active Trials
NCT01222299Completed89Est. Aug 2010
NCT01277341Completed601Est. May 2011
NCT01753739Completed617Est. May 2013
+1 more trials
Keymed Biosciences
Keymed BiosciencesChina - Chengdu
1 program
1
CM310Phase 21 trial
Active Trials
NCT06171074Unknown100Est. Mar 2025
Ono Pharmaceutical
Ono PharmaceuticalJapan - Osaka
1 program
1
CetirizinePhase 21 trial
Active Trials
NCT01748344Completed58
BioTherapeutics Inc
BioTherapeutics IncVA - Blacksburg
1 program
1
IRL201104Phase 2
Shionogi
ShionogiJapan - Osaka
1 program
1
S-555739 Dose 1Phase 21 trial
Active Trials
NCT01651871Completed779Est. May 2013
Pfizer
PfizerNEW YORK, NY
1 program
1
Intra-nasal allergen challenge with Phleum pratense.Phase 11 trial
Active Trials
NCT00483353Completed6
UCB Pharma
UCB PharmaBelgium - Brussels
5 programs
NACN/A1 trial
1 week of treatment discontinuationPHASE_41 trial
LevocetirizinePHASE_41 trial
levocetirizine dihydrochloridePHASE_41 trial
levocetirizine dihydrochloridePHASE_41 trial
Active Trials
NCT03450031Completed24Est. Oct 2018
NCT00223587Terminated22Est. Jan 2008
NCT00160537Completed200Est. Jul 2005
+2 more trials
Teva
TevaIsrael - Petach Tikva
5 programs
Mometasone furoatePHASE_1_21 trial
Beclomethasone dipropionate HFA Nasal AerosolPHASE_21 trial
Azelastine hydrochloride and Fluticasone propionatePHASE_31 trial
BDP HFAPHASE_31 trial
Beclomethasone dipropionatePHASE_31 trial
Active Trials
NCT01523236Completed800Est. Jan 2012
NCT00854360Completed487Est. May 2009
NCT02249663Unknown1,535
+2 more trials
Faes Farma
Faes FarmaSpain - Leioa
5 programs
BilastinePHASE_2
BilastinePHASE_21 trial
BilastinePHASE_21 trial
BilastinePHASE_31 trial
bilastinePHASE_31 trial
Active Trials
NCT00420082Completed75Est. Dec 2006
NCT00574210Completed502Est. Feb 2008
NCT01108783Completed720Est. Feb 2004
+1 more trials
Chia Tai TianQing Pharmaceutical Group
3 programs
TQC2938 injectionPHASE_21 trial
TQH2722 injectionPHASE_21 trial
TQH2722 injectionPHASE_21 trial
Active Trials
NCT07052097Completed136Est. Nov 2025
NCT07398859Recruiting300Est. Mar 2027
NCT06760182Completed169Est. Jul 2025
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
1 program
Fluticasone propionateN/A2 trials
Active Trials
NCT00755066Completed48
NCT02778867Completed129Est. May 2019
Stallergenes Greer
Stallergenes GreerFrance - Antony
1 program
300 IR grass pollen allergen extract tabletPHASE_11 trial
Active Trials
NCT00619827Completed89Est. Mar 2008
Merck & Co.
Merck & Co.RAHWAY, NJ
1 program
Epinastine Nasal SprayPHASE_2
Revolo Biotherapeutics
1 program
IRL201104PHASE_21 trial
Active Trials
NCT05098522Completed63Est. Mar 2023
Novartis
NovartisBASEL, Switzerland
1 program
Azelastine + Mometazone, nasal sprayPHASE_31 trial
Active Trials
NCT05590598Completed472Est. Jun 2023

+1 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
GSKPL nasal spray
AlconOlopatadine HCl Nasal Spray, 0.6%
AlconOlopatadine HCL Nasal Spray, 0.6%
UCB Pharmalevocetirizine dihydrochloride
UCB Pharmalevocetirizine dihydrochloride
BayerAzelastine and placebo
GSKfluticasone furoate
MSDmontelukast
Integrated BiosciencesMometasone Furoate Nasal Spray
UCB PharmaLevocetirizine
UCB Pharma1 week of treatment discontinuation
SanofiFexofenadine HCl
Allergopharmagrass
Longbio PharmaLP-003
NovartisAzelastine + Mometazone, nasal spray

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 21,902 patients across 50 trials

NCT01007253GSKPL nasal spray

Effect of Veramyst and Olopatadine 0.2% Opthalmic Solution on Allergy Symptoms

Start: Nov 2009Est. completion: Aug 201121 patients
Phase 4Completed
NCT00845195AlconOlopatadine HCl Nasal Spray, 0.6%

Comparison of Seasonal Allergic Rhinitis Treatment With 2 Antihistamines Used in Combination With Intranasal Corticosteroid

Start: Mar 2009150 patients
Phase 4Completed
NCT00691665AlconOlopatadine HCL Nasal Spray, 0.6%

Comparison of Olopatadine 0.6% and Fluticasone Proprionate 50mcg Nasal Sprays in a Two Week Seasonal Allergic Rhinitis Trial

Start: May 2008130 patients
Phase 4Completed
NCT00653224UCB Pharmalevocetirizine dihydrochloride

A Study Evaluating the Efficacy and Impact on Health-related Quality of Life of Levocetirizine in Adults With Seasonal Allergic Rhinitis

Start: Apr 2008Est. completion: Jul 2008580 patients
Phase 4Completed
NCT00621959UCB Pharmalevocetirizine dihydrochloride

A Study Evaluating the Efficacy and Impact on Health-related Quality of Life of Levocetirizine in Adults With Seasonal Allergic Rhinitis

Start: Mar 2008Est. completion: Jun 2008596 patients
Phase 4Completed
NCT00561717BayerAzelastine and placebo

A Randomized, Placebo Controlled Study to Determine the Efficacy and Speed of a Nasal Spray in Allergen Induced Seasonal Allergic Rhinitis

Start: Oct 2007Est. completion: Feb 200870 patients
Phase 4Completed
NCT00473915GSKfluticasone furoate

Intranasal Steroids and the Nasal Ocular Response

Start: Apr 2007Est. completion: Feb 200820 patients
Phase 4Completed
NCT00559546MSDmontelukast

Montelukast as a Controller of Atopic Syndrome

Start: Mar 2007Est. completion: Jul 200761 patients
Phase 4Completed
NCT00358527Integrated BiosciencesMometasone Furoate Nasal Spray

Mometasone Furoate on Sleep Disturbances in Subjects With Seasonal Allergic Rhinitis (Study P04608) (COMPLETED)

Start: May 2006Est. completion: Nov 2006401 patients
Phase 4Completed
NCT00160537UCB PharmaLevocetirizine

POPULAR (Preference Of Patient Using Levocetirizine in Allergic Rhinitis)

Start: May 2005Est. completion: Jul 2005200 patients
Phase 4Completed
NCT00223587UCB Pharma1 week of treatment discontinuation

Seasonal Allergic Rhinitis and Driving Ability

Start: Sep 2004Est. completion: Jan 200822 patients
Phase 4Terminated
NCT00637611SanofiFexofenadine HCl

Single-Center, Double-Blind, Randomized , Parallel Study Comparing Onset of Action, Efficacy & Safety of a Single-Dose of Fexofenadine HCl 180 mg vs Montelukast Na 10 mg & Placebo in Treating Seasonal Allergic Rhinitis Subjects in an Allergen Exposure Unit

Start: Feb 2003Est. completion: Apr 20031,010 patients
Phase 4Completed

Comparison of Perennial and Preseasonal Subcutaneous Immunotherapy

Start: Jan 2003Est. completion: Sep 2006120 patients
Phase 4Completed

Efficacy and Safety of LP-003 Injection in Patients With Moderate to Severe Seasonal Allergic Rhinitis

Start: Aug 2024Est. completion: Dec 2026546 patients
Phase 3Active Not Recruiting
NCT05590598NovartisAzelastine + Mometazone, nasal spray

Efficacy and Safety of Azelastine +Mometasone , Nasal Spray, 140 mcg + 50 mcg, (Sandoz d.d., Slovenia) and Momat Rino Advance, Nasal Spray, 140 mcg + 50 mcg, (Glenmark, India) Administered as a Monotherapy to Patients With Seasonal Allergic Rhinitis.

Start: Feb 2023Est. completion: Jun 2023472 patients
Phase 3Completed
NCT03649139Biocorpsublingual immunotherapy drops

Effect and Underlying Immunological Mechanisms of Sublingual Immunotherapy in Allergic Rhinitis

Start: Apr 2017Est. completion: Oct 201871 patients
Phase 3Completed
NCT02245360AbbottPhleum pratense grass pollen allergen extract

Study Immunology and Safety of 60-day Treatment of SQ Grass SLIT (Sublingual Immunotherapy)-Tablet in Adult Subjects With Grass Pollen-induced Allergic Rhinoconjunctivitis

Start: Oct 2014Est. completion: Mar 2015107 patients
Phase 3Completed
NCT02249663TevaAzelastine hydrochloride and Fluticasone propionate

Clinical Equivalence of Azelastine Hydrochloride and Fluticasone Propionate, 137/50 mcg Nasal Spray to Dymista™

Start: Aug 20141,535 patients
Phase 3Unknown

Efficacy and Safety of Ciclesonide Nasal Spray in Participants With Seasonal Allergic Rhinitis (SAR) in Russia

Start: Aug 2014Est. completion: Nov 201480 patients
Phase 3Completed

Efficacy, Safety, and Tolerability Study of ACT-129968 in Patients With Seasonal Allergic Rhinitis

Start: Dec 2011Est. completion: Mar 2012630 patients
Phase 3Completed
NCT01413958BayerPhenylephrine

Effects of Phenylephrine Extended-Release Tablets on Allergy-Related Nasal Congestion (P08498 AM1)

Start: Aug 2011Est. completion: Oct 2011575 patients
Phase 3Completed

Study of an Investigational Nasal Aerosol or Placebo Nasal Aerosol in Children (Ages 6-11) With Seasonal Allergies

Start: Mar 2011Est. completion: Aug 2011715 patients
Phase 3Completed
NCT01024608TevaBeclomethasone dipropionate

Study in Adult and Adolescent Subjects With Seasonal Allergic Rhinitis (SAR)

Start: Dec 2009Est. completion: Feb 2010340 patients
Phase 3Completed
NCT00564421MSDepinastine nasal spray, low concentration, low dose volume

Safety and Efficacy Study of Epinastine Nasal Spray in Subjects With Seasonal Allergic Rhinitis (P08648)

Start: Dec 2007Est. completion: Feb 2008798 patients
Phase 3Completed
NCT00578929AlconOlopatadine Hydrochloride Nasal Spray 0.6%

Safety and Efficacy of Olopatadine HCl Nasal Spray in 6-11 Year Old Patients

Start: Sep 20072,388 patients
Phase 3Completed

Efficacy Study for the Symptomatic Treatment of Seasonal Allergic Rhinitis

Start: May 2005Est. completion: Nov 2005683 patients
Phase 3Completed

A Phase III Efficacy Study of the Symptomatic Treatment of Seasonal Allergic Rhinitis With Bilastine

Start: Apr 2003Est. completion: Feb 2004720 patients
Phase 3Completed

Rhinocort Aqua Versus Placebo and Fluticasone Propionate

Start: Apr 2003Est. completion: Jul 2003750 patients
Phase 3Completed
NCT02778867Allergy TherapeuticsFluticasone propionate

SOFEED: Six Food vs. One Food Eosinophilic Esophagitis Diet Study

Start: May 2016Est. completion: May 2019129 patients
Phase 2/3Completed

Clinical Study on TQH2722 Injection Combined With Background Therapy for Seasonal Allergic Rhinitis

Start: Mar 2026Est. completion: Mar 2027300 patients
Phase 2Recruiting

Clinical Trial of TQC2938 Injection in Patients With Seasonal Allergic Rhinitis

Start: Jul 2025Est. completion: Nov 2025136 patients
Phase 2Completed

Clinical Trial of TQH2722 Injection in Patients With Seasonal Allergic Rhinitis

Start: Mar 2025Est. completion: Jul 2025169 patients
Phase 2Completed

Study of CM310 in Subjects With Seasonal Allergic Rhinitis

Start: Mar 2024Est. completion: Mar 2025100 patients
Phase 2Unknown

Efficacy and Safety of LP-003 in Moderate-to-severe Seasonal Allergic Rhinitis Adult

Start: Jul 2023Est. completion: Aug 2024180 patients
Phase 2Completed

Allergen Challenge Trial of IRL201104 in Seasonal Allergic Rhinitis

Start: Nov 2021Est. completion: Mar 202363 patients
Phase 2Completed
NCT01753739Bausch HealthBepotastine besilate

Bepotastine Besilate Nasal Sprays in the Treatment of Seasonal Allergic Rhinitis (SAR)

Start: Jan 2013Est. completion: May 2013617 patients
Phase 2Completed

Phase II Study Evaluating ONO-4053 and Cetirizine in Subjects With Seasonal Allergic Rhinitis

Start: Nov 201258 patients
Phase 2Completed
NCT01651871ShionogiS-555739 Dose 1

Combination Study Of S-555739/Cetirizine HCl In Adult Patients With Seasonal Allergic Rhinitis

Start: Jul 2012Est. completion: May 2013779 patients
Phase 2Completed
NCT01578278Bausch HealthBepotastine besilate formulation

Bepotastine Besilate-corticosteroid Nasal Spray Combination Compared to Placebo, Bepotastine Besilate Nasal Spray, and Corticosteroid Nasal Spray in the Treatment of Patients With Seasonal Allergic Rhinitis

Start: Dec 2011Est. completion: Aug 2012606 patients
Phase 2Completed
NCT01277341Bausch HealthBepotastine Besilate Nasal Spray 2% Twice a day

Safety and Efficacy of Bepotastine Besilate Nasal Spray in the Treatment of Seasonal Allergic Rhinitis

Start: Dec 2010Est. completion: May 2011601 patients
Phase 2Completed

Study of ACT-129968 in Adult Patients With Seasonal Allergic Rhinitis

Start: Nov 2010Est. completion: Feb 2011579 patients
Phase 2Completed
NCT00854360TevaBeclomethasone dipropionate HFA Nasal Aerosol

Study to Assess the Efficacy and Safety of BDP HFA Nasal Aerosol in Patients 12 Years and Older With SAR

Start: Mar 2009Est. completion: May 2009487 patients
Phase 2Completed
NCT00673062MSDSCH 900538

Study of the Effect of SCH 900538 on Congestion in Subjects With Seasonal Allergic Rhinitis (Study P05031)(COMPLETED)

Start: May 2008Est. completion: Jul 2008265 patients
Phase 2Completed

Efficacy, Safety and PK of Once or Twice Daily Bilastine (10 or 20 mg) Compared With Placebo in the Symptomatic Treatment of SAR

Start: Dec 2007Est. completion: Mar 2008805 patients
Phase 2Completed

PK/PD and Steady State Efficacy Study of Bilastine Compared With Placebo Given Orally in the Treatment of the Symptoms of SAR in an EEC Model (5-arm)

Start: Oct 2007Est. completion: Feb 2008502 patients
Phase 2Completed
NCT00407927MSDEpinastine Nasal Spray

A Study of Epinastine Nasal Spray in Subjects With Seasonal Allergic Rhinitis

Start: Dec 2006Est. completion: Mar 2007571 patients
Phase 2Completed

A Randomized, Double-Blind, 4-way Crossover Study to Evaluate the Efficacy of Bilastine in the Vienna Challenge Chamber

Start: Oct 2006Est. completion: Dec 200675 patients
Phase 2Completed

New Nasal Applicator / New Formulation - User Study

Start: Apr 2002Est. completion: Aug 2002200 patients
Phase 2Completed
NCT01523236TevaMometasone furoate

Clinical Equivalence Study of Mometasone Nasal Spray, 50 Mcg/Actuation

Start: Dec 2011Est. completion: Jan 2012800 patients
Phase 1/2Completed
NCT01222299Bausch Healthbepotastine besilate nasal product - low dose

Safety, Pharmacokinetics, and Efficacy of Bepotastine Besilate Nasal Product After Ragweed Pollen Exposure in an Environmental Chamber

Start: May 2010Est. completion: Aug 201089 patients
Phase 1/2Completed

Related Jobs

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

13 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 21,902 patients
30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.