NDASUBCUTANEOUSPOWDER
Approved
Aug 2000
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
2
Data completeness
4/8 — Partial
CETROTIDE (cetrorelix acetate) by Gland Pharma is clinical pharmacology gnrh induces the production and release of luteinizing hormone (lh) and follicle stimulating hormone (fsh) from the gonadotrophic cells of the anterior pituitary. First approved in 2000.
Drug data last refreshed 4h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Cetrotide (cetrorelix acetate) is a GnRH antagonist administered subcutaneously that suppresses luteinizing hormone (LH) and follicle-stimulating hormone (FSH) to prevent premature ovulation during controlled ovarian stimulation for assisted reproductive technologies. It works by competing with natural GnRH for pituitary receptor binding, providing rapid onset of LH suppression (1–2 hours) with reversible effects upon discontinuation.
LOE Approaching
Product approaching loss of exclusivity with moderate competitive pressure (30/100); brand and commercial teams face near-term transition planning and potential headcount rationalization.
Mechanism of Action
CLINICAL PHARMACOLOGY GnRH induces the production and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the gonadotrophic cells of the anterior pituitary. Due to a positive estradiol (E2) feedback at midcycle, GnRH liberation is enhanced resulting in an LH-surge. This…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.