NDAORALTABLET
Approved
Apr 1961
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
5/8 — Partial
CELESTONE (betamethasone) by Merck & Co. is clinical pharmacology glucocorticoids, naturally occurring and synthetic, are adrenocortical steroids that are readily absorbed from the gastrointestinal tract. Approved for psoriasis, atopic dermatitis, skin and connective tissue diseases and 1 more indications. First approved in 1961.
Drug data last refreshed 20h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
CELESTONE (betamethasone) is a synthetic glucocorticoid oral tablet approved in 1961 that works by enhancing anti-inflammatory action through a 16β-methyl group while reducing sodium and water retention. It treats a broad spectrum of conditions including dermatologic disorders (psoriasis, atopic dermatitis, hand eczema), ophthalmic conditions (dry eye disease, diabetic macular edema, branch retinal vein occlusion), respiratory conditions (chronic rhinosinusitis, rhinitis), and systemic conditions (arthritis, granulomatous mastitis, preterm labor, melanoma). The drug's mechanism relies on glucocorticoid-mediated immunosuppression and anti-inflammatory effects across multiple organ systems.
$0.002BPart D
LOE ApproachingMinimal commercial growth signals with only 43 Part D claims in 2023; brand team focus is likely on defensive positioning and indication management rather than expansion.
Mechanism of Action
CLINICAL PHARMACOLOGY Glucocorticoids, naturally occurring and synthetic, are adrenocortical steroids that are readily absorbed from the gastrointestinal tract. Naturally occurring glucocorticoids (hydrocortisone and cortisone), which also have salt-retaining properties, are used as replacement…
Indications (4)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.