BUPRENORPHINE HYDROCHLORIDE AND NALOXONE HYDROCHLORIDE
Post-LOEbuprenorphine and naloxone
ANDASUBLINGUALTABLET
Approved
Dec 2025
Lifecycle
Post-LOE
Competitive Pressure
30/100
Mechanism of Action
naloxone. Buprenorphine is a partial agonist at the mu‐opioid receptor and an antagonist at the kappa‐opioid receptor. Naloxone is an opioid antagonist and produces opioid withdrawal signs and symptoms in individuals physically dependent on full opioid agonists when administered parenterally.