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Opioid Dependence

6
Pipeline Programs
14
Companies
21
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
1
0
2
2
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

14 companies ranked by most advanced pipeline stage

Indivior
IndiviorUK - Slough
4 programs
1
1
1
1
Suboxone Sublingual FilmPhase 41 trial
SUBOXONEPhase 31 trial
RBP-8000 100 mgPhase 21 trial
INDV-2000Phase 11 trial
Active Trials
NCT04413552Completed73Est. Apr 2021
NCT01846481Completed40Est. Jun 2013
NCT02357901Completed665Est. Apr 2016
+1 more trials
Alkermes
AlkermesDUBLIN 4, Ireland
2 programs
1
VIVITROL 380mgPhase 41 trial
ALK21-025: Vivitrol's Cost and Treatment Outcomes RegistryN/A1 trial
Active Trials
NCT01422837Completed403Est. Oct 2013
NCT01453374Completed27Est. May 2014
Eppendorf
EppendorfGermany - Hamburg
2 programs
1
DiacetylmorphinePhase 31 trial
Opiate Substitution TreatmentN/A1 trial
Active Trials
NCT01722435Completed78Est. Feb 2014
NCT00268814Completed1,015Est. Dec 2007
US WorldMeds
US WorldMedsKY - Louisville
4 programs
Lofexidine HClPHASE_11 trial
Lofexidine HClPHASE_11 trial
Lofexidine HClPHASE_11 trial
Lofexidine HClPHASE_31 trial
Active Trials
NCT01820442Completed30Est. Sep 2013
NCT01558934Completed6Est. Apr 2012
NCT01650649Completed27Est. Dec 2012
+1 more trials
Labcorp
LabcorpBURLINGTON, NC
2 programs
ActiGraph LinkN/A1 trial
Vivitrol Injectable ProductPHASE_11 trial
Active Trials
NCT02896660Unknown15Est. Apr 2017
NCT05620940Recruiting40Est. Dec 2025
Innovation Pharmaceuticals
1 program
ActiGraph LinkN/A
Braeburn Pharmaceuticals
Braeburn PharmaceuticalsPA - Plymouth Meeting
1 program
ActiGraph LinkN/A
Corner Therapeutics
Corner TherapeuticsMA - Watertown
1 program
Community-based buprenorphine treatmentN/A1 trial
Active Trials
NCT01761110Completed77Est. Feb 2014
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
1 program
MOUD "Plus" InterventionN/A1 trial
Active Trials
NCT06837662Recruiting70Est. Dec 2026
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
1 program
Starting Treatment With Agonist Replacement Therapies Follow-up StudyN/A1 trial
Active Trials
NCT01592461Completed877Est. Aug 2016
Alliance Pharmaceuticals
1 program
long-acting depot buprenorphineN/A1 trial
Active Trials
NCT06129916Not Yet Recruiting760Est. Jun 2027
Human BioSciences
Human BioSciencesWV - Martinsburg
1 program
mABCN/A1 trial
Active Trials
NCT04454645Unknown200Est. Mar 2026
Providence Therapeutics
1 program
Hydromorphone, InjectablePHASE_31 trial
Active Trials
NCT01447212Completed202Est. Feb 2016
City Therapeutics
City TherapeuticsMA - Cambridge
1 program
Buprenorphine Extended ReleasePHASE_41 trial
Active Trials
NCT03604159CompletedEst. May 2020

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
City TherapeuticsBuprenorphine Extended Release
IndiviorSuboxone Sublingual Film
AlkermesVIVITROL 380mg
IndiviorSUBOXONE
US WorldMedsLofexidine HCl
Providence TherapeuticsHydromorphone, Injectable
EppendorfDiacetylmorphine
IndiviorRBP-8000 100 mg
LabcorpVivitrol Injectable Product
IndiviorINDV-2000
US WorldMedsLofexidine HCl
US WorldMedsLofexidine HCl
US WorldMedsLofexidine HCl
Alliance Pharmaceuticalslong-acting depot buprenorphine
Oregon TherapeuticsMOUD "Plus" Intervention

Showing 15 of 21 trials with date data

Clinical Trials (21)

Total enrollment: 5,241 patients across 21 trials

NCT03604159City TherapeuticsBuprenorphine Extended Release

XRB vs. SLB in Jail and at Re-entry: Pilot, Proof of Concept

Start: Jun 2019Est. completion: May 2020
Phase 4Completed
NCT02038790IndiviorSuboxone Sublingual Film

Usability of Zubsolv Sublingual Tablets 5.7/1.4 to Suboxone Sublingual Film 8/2 In Buprenorphine/Naloxone Treated Opioid Dependent Population

Start: Nov 2013Est. completion: Nov 201333 patients
Phase 4Completed
NCT01453374AlkermesVIVITROL 380mg

A Study of VIVITROL in the Prevention of Re-arrest and Re-incarceration

Start: Jan 2011Est. completion: May 201427 patients
Phase 4Completed

Treatment Seeking Participants With Opioid Use Disorders Assessing Tolerability of Depot Injections of Buprenorphine

Start: Jan 2015Est. completion: Apr 2016665 patients
Phase 3Completed

Efficacy, Safety and Dose-Response Study Followed by Open-Label Study of Lofexidine Treatment of Opioid Withdrawal

Start: Jun 2013Est. completion: Dec 2014603 patients
Phase 3Completed
NCT01447212Providence TherapeuticsHydromorphone, Injectable

Study to Assess Longer-term Opioid Medication Effectiveness (SALOME)

Start: Dec 2011Est. completion: Feb 2016202 patients
Phase 3Completed
NCT00268814EppendorfDiacetylmorphine

The German Project of Heroin Assisted Treatment of Opiate Dependent Patients

Start: Mar 2002Est. completion: Dec 20071,015 patients
Phase 3Completed
NCT01846481IndiviorRBP-8000 100 mg

A Randomized, 4-sequence, 2-period, Double-blind, Placebo Controlled Study With a DSM-IV-TR Diagnosis of Cocaine Abuse

Start: Apr 2013Est. completion: Jun 201340 patients
Phase 2Completed
NCT05620940LabcorpVivitrol Injectable Product

A Clinical Trial to Assess Pharmacokinetic Profiles, Safety and Tolerability of IVL3004 and IVL4002 in Healthy Male Subjects.

Start: Sep 2024Est. completion: Dec 202540 patients
Phase 1Recruiting

INDV-2000 First in Human

Start: Jul 2020Est. completion: Apr 202173 patients
Phase 1Completed

Pharmacokinetic & Pharmacodynamic Interaction of Lofexidine and Buprenorphine in Buprenorphine Maintained Patients

Start: Mar 2013Est. completion: Sep 201330 patients
Phase 1Completed

Main Study of Lofexidine and Methadone Pharmacodynamic Interaction in Methadone Maintained Patients

Start: Jul 2012Est. completion: Dec 201227 patients
Phase 1Completed

Pilot Study of Lofexidine and Methadone Pharmacodynamic Interaction in Methadone Maintained Patients

Start: Feb 2012Est. completion: Apr 20126 patients
Phase 1Completed
NCT06129916Alliance Pharmaceuticalslong-acting depot buprenorphine

Assessing the Acceptability, Feasibility, Effectiveness and Cost-effectiveness of LADB

Start: Nov 2025Est. completion: Jun 2027760 patients
N/ANot Yet Recruiting
NCT06837662Oregon TherapeuticsMOUD "Plus" Intervention

The MOUD Plus Pilot: Counseling and Peer Support to Support Retention for Medically Complex Patients With Opioid Use Disorder Seen In Primary Care

Start: Mar 2025Est. completion: Dec 202670 patients
N/ARecruiting

Intervening With Opioid-Dependent MothersMothers and Infants

Start: May 2020Est. completion: Mar 2026200 patients
N/AUnknown
NCT02896660LabcorpActiGraph Link

Probuphine Innovations for Clinical Effectiveness (PRINCE)

Start: Sep 2016Est. completion: Apr 201715 patients
N/AUnknown
NCT01761110Corner TherapeuticsCommunity-based buprenorphine treatment

Pilot Test of a Community-based Buprenorphine Treatment Intervention

Start: Dec 2012Est. completion: Feb 201477 patients
N/ACompleted
NCT01422837AlkermesALK21-025: Vivitrol's Cost and Treatment Outcomes Registry

ALK21-025: Vivitrol's Cost and Treatment Outcomes Registry

Start: Aug 2011Est. completion: Oct 2013403 patients
N/ACompleted
NCT01722435EppendorfOpiate Substitution Treatment

Completion of OST - a Prospective Study

Start: Jul 2011Est. completion: Feb 201478 patients
N/ACompleted
NCT01592461Angeles TherapeuticsStarting Treatment With Agonist Replacement Therapies Follow-up Study

Starting Treatment With Agonist Replacement Therapies Follow-up Study

Start: Sep 2010Est. completion: Aug 2016877 patients
N/ACompleted

Related Jobs

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 late-stage (Phase 3) programs, potential near-term approvals
2 actively recruiting trials targeting 5,241 patients
14 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.