BUPRENORPHINE HYDROCHLORIDE AND NALOXONE HYDROCHLORIDE
Post-LOEbuprenorphine and naloxone
ANDABUCCAL, SUBLINGUALFILM
Approved
Jun 2022
Lifecycle
Post-LOE
Competitive Pressure
30/100
Mechanism of Action
naloxone. Buprenorphine is a partial agonist at the mu-opioid receptor and an antagonist at the kappa-opioid receptor. Naloxone is a potent antagonist at mu-opioid receptors and produces opioid withdrawal signs and symptoms in individuals physically dependent on full opioid agonists when…