BETAPACE

LOE Approaching

sotalol hydrochloride

NDAORALTABLETPriority Review
Approved
Oct 1992
Lifecycle
LOE Approaching
Competitive Pressure
30/100

Mechanism of Action

beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. The two isomers of sotalol have similar Class III antiarrhythmic effects, while the l-isomer is responsible for virtually all of the…