NDAORALTABLET
Approved
Sep 1980
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
ASENDIN (amoxapine) by Pfizer is clinical pharmacology amoxapine is an antidepressant with a mild sedative component to its action. Approved for depression, anxiety. First approved in 1980.
Drug data last refreshed 20h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ASENDIN (amoxapine) is an oral tricyclic antidepressant approved in 1980 that inhibits reuptake of norepinephrine and serotonin while blocking dopamine receptors, with mild sedative properties. It treats depression and anxiety with a faster onset of action (4-7 days initially, 2 weeks for 80% of responders) compared to earlier tricyclics like amitriptyline and imipramine. The drug is almost completely metabolized with a primary half-life of 8 hours, though its major metabolite has a 30-hour half-life.
LOE Approaching
As a 44-year-old product approaching loss of exclusivity with modest competitive pressure (30%), team focus is likely on maximizing remaining market share through generic lifecycle management and selective indications.
Mechanism of Action
CLINICAL PHARMACOLOGY Amoxapine is an antidepressant with a mild sedative component to its action. The mechanism of its clinical action in man is not well understood. In animals, amoxapine reduced the uptake of norepinephrine and serotonin and blocked the response of dopamine receptors to dopamine.…
Indications (2)
Worked on ASENDIN at Pfizer? Share your interview experience or compensation data (+7 days Pro)
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.