NDAORALTABLET
Approved
Mar 1968
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
ALDOCLOR-250 (chlorothiazide; methyldopa) by Merck & Co. is clinical pharmacology: the mechanism of the antihypertensive effect of thiazides is unknown. Approved for pregnancy, just, heart failure and 2 more indications. First approved in 1968.
Drug data last refreshed 2h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ALDOCLOR-250 is a fixed-dose oral combination of chlorothiazide (a thiazide diuretic) and methyldopa (a central-acting antihypertensive) indicated for hypertension management. Chlorothiazide promotes sodium and chloride excretion in the distal renal tubule, while methyldopa's mechanism remains incompletely understood but provides additive blood pressure reduction. This combination targets patients requiring dual-agent therapy for hypertension control.
LOE Approaching
Product is in late-stage maturity approaching loss of exclusivity; brand team focus is likely on lifecycle management and transition planning rather than growth initiatives.
Mechanism of Action
CLINICAL PHARMACOLOGY: The mechanism of the antihypertensive effect of thiazides is unknown. Chlorothiazide does not usually affect normal blood pressure. Chlorothiazide affects the distal renal tubular mechanism of electrolyte reabsorption. At maximal therapeutic dosage all thiazides are…
Indications (5)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.