NDAOralTablet, Delayed Release
Approved
Nov 2002
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
12
Data completeness
5/8 — Partial
ACIPHEX (rabeprazole sodium) by Eisai is (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine h 2 -receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric h, katpase at the secretory surface of the gastric parietal cell. Approved for gastroesophageal reflux disease, heartburn, helicobacter pylori infection. First approved in 2002.
Drug data last refreshed 22h ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ACIPHEX (rabeprazole sodium) is an oral delayed-release proton-pump inhibitor (PPI) approved in 2002 for treating daytime and nighttime heartburn and other symptoms associated with gastroesophageal reflux disease (GERD) in adults for up to 4 weeks, and in adolescents 12 years and older for up to 8 weeks. It works by irreversibly inhibiting the gastric H+/K+-ATPase pump on parietal cells, blocking the final step of gastric acid secretion. The drug is chemically activated at low pH with rapid kinetics (half-life of 78 seconds in vitro), making it a potent and effective acid suppressant. ACIPHEX occupies a mature position in the crowded PPI market, competing against omeprazole, esomeprazole, lansoprazole, and pantoprazole generics.
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Mechanism of Action
(substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H 2 -receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H, KATPase at the secretory surface of the gastric parietal cell. Because this enzyme is regarded as…
Indications (3)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.