Pierre Fabre is the 2nd largest dermo-cosmetics laboratory in the world, the 2nd largest private French pharmaceutical group and the market leader in France for products sold over the counter in pharmacies.

Its portfolio includes several medical franchises and international brands including Pierre Fabre Oncologie, Pierre Fabre Dermatologie, Eau Thermale Avène, Klorane, Ducray, René Furterer, A-Derma, Naturactive, Pierre Fabre Oral Care. 

Established in the Occitanie region since its creation, and manufacturing over 95% of its products in France, the Group employs some 10,000 people worldwide. Its products are distributed in about 130 countries. 86% of the Pierre Fabre Group is held by the Pierre Fabre Foundation, a government-recognized public-interest foundation, while a smaller share is owned by its employees via an employee stock ownership plan. 

In 2019, Ecocert Environment assessed the Group’s corporate social and environmental responsibility approach in accordance with the ISO 26000 sustainable development standard and awarded it the “Excellence” level.

Pierre Fabre is recognized as one of the "World's Best Employers 2021" by Forbes. Our group is ranked in the Top 3 in the cosmetics industry and in the Top 10 in the pharmaceutical industry worldwide. 

Your mission

We are seeking a Translational PK/PD Modeler to join the PKPD/Tox Modeling & Simulation Team within the R&D Pharma at Pierre Fabre Laboratories in Toulouse (Langlade site, Oncopole).

Who You are

You are a proactive modeling scientist who translates preclinical complexity into actionable clinical predictions through rigorous yet pragmatic quantitative approaches. You communicate modeling insights clearly across disciplines from medicinal chemistry to clinical development, and you thrive in collaborative environments where your analyses directly influence critical development decisions. You balance technical excellence with strategic judgement, understanding that impactful modeling requires both scientific rigor and the ability to build trust and credibility with cross-functional stakeholders.

Your role within a pioneering company in full expansion:

What You’ll Do

• Provide strategic translational leadership and translate findings into clear recommendations to drive critical decisions across discovery and early clinical development
• Develop and apply advanced PK/PD models with a focus on oncology programs to guide candidate selection, interspecies extrapolation, FIH dose selection, and a mechanistic understanding of exposure-response relationships
• Evaluate PK/PD relationships across in vitro, in vivo, and emerging clinical data to assess translatability and identify potential disconnects
• Provide quantitative support for IND submissions, including nonclinical pharmacology sections and FIH dose justification
• Communicate PK/PD modeling results to diverse stakeholders and actively influence decision-making in project teams
• Identify opportunities where translational PK/PD modeling can contribute to a better understanding of efficacious exposure and dosing strategies
• Educate cross-functional teams on translational modeling capabilities and appropriate use of quantitative tools
• Collaborate with Clinical Pharmacologists and Pharmacometricians to ensure seamless handoff and continuity of modeling strategy into later clinical development
• Contribute to scientific publications and present at internal or external scientific conferences to establish thought leadership

This position is compatible with teleworking up to 2 days a week according to company rules.

We offer an attractive remuneration/benefits package: Incentives, profit-sharing, Pierre Fabre shareholding with matching contribution, health and provident insurance, 16 days of holidays (RTT) in addition to 25 days of personal holidays, public transport participation...

Your skills at the service of innovative projects:

Required Qualifications:

• PhD in Pharmaceutical Sciences, Computational Biology, Applied Mathematics, or a related quantitative field
• Minimum 5+ years of post-PhD experience preclinical/translational PK/PD modeling in the pharmaceutical or biotech industry
• Expert-level knowledge in preclinical PK/PD with strong experience in oncology-relevant PK/PD models (e.g., TGI models, resistance/adaptation models, survival models, time-to-event models, systems pharmacology models etc.)
• Strong proficiency in programming language (e.g., R, MATLAB, Python) and at least one relevant modeling software (e.g., Monolix, NONMEM, PK-Sim)
• Strong understanding of oncology drug development, including preclinical model systems, biomarkers, and clinical endpoints
• Understanding of regulatory expectations (e.g., ICH S9, FDA guidance on Dosage Optimizing for the Treatment of Oncologic Diseases)
• Strong scientific writing skills and experience in contributing to regulatory submissions (INDs) and scientific publications
• Comfortable with ambiguity and ability to make pragmatic decisions with incomplete data
• Excellent interpersonal skills and the ability to work in cross-functional teams
• Excellent written and verbal skills in English

Preferred Qualifications:

• Demonstrated scientific leadership through a publication track record in oncology
• Experience in PBPK and quantitative systems pharmacology (QSP) models
• Experience in modeling multiple therapeutic modalities beyond small molecules (biologics, targeted therapies, ADCs)
• Experience mentoring junior scientists and leading technical workstreams

We are convinced that diversity is a source of fulfillment, social balance and complementarity for our employees, which is why our offers are open to all, without restriction.