Senior Scientist, Translational Medicines & Biomarkers

Position Summary:

The Senior Scientist ,Translational Medicines & Biomarkers will provide scientific leadership and support across clinical and preclinical development programs.

The successful candidate will be responsible for developing and executing translational and biomarker strategies, interpreting biomarkers data integration with PK, PD, ADA, NAb, efficacy, and safety data, and supporting the advancement of clinical-stage and early pipeline programs.

This role requires a scientist who can independently analyze complex datasets, develop scientifically rigorous conclusions, and communicate actionable recommendations to multidisciplinary teams and senior leadership.

Essential Duties and Responsibilities:

Clinical biomarker and translational strategy

• Develop and implement biomarker and translational strategies for clinical-development programs
• Identify pharmacodynamic and potentially predictive, prognostic, and patient-stratification biomarkers
• Provide immunoassays (including PK and PD) input into clinical protocols and sampling schedules.
• Ensure that biomarker plans address the key clinical-development questions for each program
• Evaluate assay readiness, feasibility, validation requirements, and sample-handling considerations

Clinical-data analysis and interpretation

• Lead or support analysis of clinical biomarker datasets
• Integrate biomarker results with efficacy, safety, PK, ADA, NAb, and patient-characteristic data to generate a clear PD picture
• Evaluate response-associated biomarkers, disease subgroups, and potential confounding factors
• Distinguish exploratory signals from robust and biologically meaningful findings
• Develop clear scientific conclusions and recommendations
• Identify additional analyses required to address emerging questions

Early pipeline Support

• Evaluate target biology, mechanisms of action, and disease rationale

• Develop translational plans for early development programs
• Design or recommend experiments to test key mechanistic hypotheses
• Lead CRO oversights, including assay designs, assays executions and raw data analysis.
• Support candidate-selection and indication-selection decisions

Cross-functional collaboration

• Work closely with all stakeholders to ensure program success
• Collaborate with CROs, bioanalytical laboratories, consultants, and academic experts
• Represent Translational Medicine and Biomarkers in program team meetings
• Communicate complex scientific findings clearly to scientific stakeholders

Scientific communication

• Prepare internal data-review presentations and program recommendations
• Conduct literature reviews and competitive landscape assessments

Required Education and Experience:

• PhD or advanced equivalent degree in immunology, molecular biology, biomedical engineering or a related discipline
• 5-8 years of experience in pharmaceutical development, or translational clinical research, specifically in the I&I space
• Experience in hands-on programming for single cell RNA-seq and protein biomarkers analysis including statistics and machine learning knowledge- significant advantage.
• Strong understanding in in-vitro cell-based assays, and in-vivo inflammatory diseases models
• Ability to integrate complex data from multiple sources
• Demonstrated ability to independently develop and communicate scientific conclusions and recommendations
• Experience working with cross-functional clinical-development teams
• Strong scientific writing skills
• Ability to manage multiple programs and priorities in a dynamic biotechnology environment

Preferred Qualifications

• Experience with monoclonal antibody development
• Experience in hidradenitis suppurativa, inflammatory diseases, rheumatology, dermatology, or autoinflammatory diseases
• Familiarity with cytokine biology and immune-pathway modulation
• Experience with multiplex biomarker platforms
• Experience with exploratory statistical analyses and biomarker-subgroup analyses
• Hands-on programming of large datasets – a significant advantage
• Experience managing CROs and external bioanalytical laboratories

Additional Skills, Knowledge, And/or Abilities: 

• Scientific independence
• Strong analytical and critical-thinking skills
• Ability to move from data to conclusions and recommendations
• Ability to identify the most decision-relevant scientific questions
• Attention to data quality and analytical rigor
• Ability to operate effectively with incomplete or evolving information
• Strong collaboration and communication
• Ability to balance strategic thinking with hands-on execution
• Ownership, accountability, and urgency
• Ability to manage several programs simultaneously