(Senior) Scientist, In Vitro Pharmacology

Position Summary 

At MBX Biosciences, we are advancing innovative peptide therapeutics to transform the lives of people with endocrine disorders. As a key member of our Research organization, the Scientist, In vitro Pharmacology will play a central role in generating high‑quality biological data that directly drives decision‑making across our portfolio.

In this role, you will design, develop, and execute in vitro biochemical and cell-based experiments to evaluate the potency, efficacy, and mechanism of action of our therapeutic candidates. You will serve as an integral member of multidisciplinary project teams, contributing scientific insight, experimental recommendations, and clear data interpretation to advance programs from early research through development.

Key Responsibilities 

• Support the design, development and execution of in vitro experiments to generate decision making data for portfolio programs.
• Become an integral member of research project biology teams where you will be responsible for recommending options for in vitro assays, generation of high-quality in vitro data and report results and conclusions at project team meetings.
• Design develop and execute in vitro experiments to assess the potency and efficacy of molecules.
• Utilize biochemical and cell-based assays to assess receptor affinity and potency of molecules.
• Maintain cell culture laboratory and equipment, prepare reagents and order supplies.
• Work with cell lines, proteins, peptides and nucleic acids.
• Independently perform data analysis and present results at project meetings.
• Other responsibilities as assigned.

Education & Qualifications 

• BS or MS degree in Biology, Chemistry, Immunology, Pharmacology, or a related scientific field
• 2+ years of experience performing biochemical and cell-based experiments in a lab environment.
• Experience in cell cultures and sterile techniques.
• Experience in operating and maintaining cell culture lab and relevant equipment.
• Strong understanding of in vitro pharmacology and how to design and execute experiments to support drug discovery and development.
• Experience in molecular biology, DNA cloning is desired.
• Demonstrated passion for science with a natural curiosity to ask questions, explore new concepts, and continuously deepen understanding.
• Highly trainable with the ability to quickly learn new techniques, adapt to evolving project needs, and incorporate feedback effectively
• Must demonstrate excellent teamwork, attention to detail, and problem-solving abilities.
• Strong collaborator with cross-functional teams and external partners.
• Capable of continuous learning, open-minded, curious, highly organized, and detail oriented.

Travel

You will be expected to travel periodically based on the needs of the business to the extent requested by the Company including attendance at Together Weeks, Together Days and functional meetings as requested by the Company.

Company Overview:

MBX Biosciences, Inc. (NASDAQ: MBX) is a clinical-stage biopharmaceutical company focused on the discovery and development of novel precision peptide therapies for the treatment of endocrine and metabolic disorders. The Company was founded by global leaders with a transformative approach to peptide drug design and development. Leveraging this expertise, the Company designed its proprietary Precision Endocrine Peptide™ (PEP™) platform to overcome the key limitations of unmodified and modified peptide therapies and to improve clinical outcomes and simplify disease management for patients. PEPs are selectively engineered to have optimized pharmaceutical properties, including extended time-action profiles and consistent drug concentrations with low peak-to-trough concentration ratios, consistent exposure to target tissues, and less frequent dosing. The Company is advancing a pipeline of novel candidates for endocrine and metabolic disorders with clinically validated targets, established endpoints for regulatory approval, significant unmet medical needs and large potential market opportunities. The Company’s pipeline includes its lead product candidate MBX 2109, in Phase 2 development for the treatment of chronic hypoparathyroidism (HP); MBX 1416, in Phase 1 development for the treatment of post-bariatric hypoglycemia (PBH); and an obesity portfolio that includes MBX 4291, as well as multiple discovery and pre-clinical candidates in development for the treatment of obesity. The Company is based in Carmel, Indiana. To learn more, please visit the Company website at www.mbxbio.com and follow us on LinkedIn. 

EEO Statement: 

MBX Biosciences is an Equal Opportunity Employer and is committed to treating all applicants fairly without discrimination. We welcome applications from all individuals, regardless of race, national origin, gender, age, physical characteristics, social origin, disability, union membership, religion, family status, pregnancy, sexual orientation, gender identity, gender expression or any unlawful criterion under applicable law.