Senior Director, HEOR – Acoramidis (Global Lead)

What You'll Do

BridgeBio is seeking a highly strategic and execution-oriented HEOR leader to define and drive the global evidence strategy for acoramidis in ATTR-CM. This individual will play a pivotal role in enabling successful global launch, optimizing payer access, and sustaining long-term product differentiation in an increasingly competitive and evolving landscape.

As the global HEOR lead, this role will shape the evidence generation agenda across the product lifecycle—spanning clinical development, launch, and post-marketing—leveraging real-world evidence (RWE), comparative effectiveness research, and patient-centered outcomes. The leader will serve as a key partner to Market Access, Medical Affairs, Clinical Development, and Commercial teams to ensure evidence translates into impactful value narratives for payers and HTA bodies worldwide.

Why This Role Matters

Acoramidis represents a transformative opportunity in ATTR-CM. This role is central to articulating and proving its value to patients, providers, and payers globally. By shaping the evidence strategy and driving impactful insights, this leader will directly influence access, adoption, and long-term success in a competitive and rapidly evolving therapeutic area.

Key Responsibilities

• Global HEOR Strategy: Define and lead the end-to-end global HEOR strategy for acoramidis across launch and lifecycle, ensuring alignment with clinical, regulatory, and commercial objectives and driving evidence-based decision-making

• Evidence Generation & Data Strategy: Design and oversee innovative real-world evidence (RWE), economic models, and data partnerships (e.g., claims, EHR, observational survey datasets) to support value demonstration and long-term evidence generation

• Payer & HTA Readiness: Develop robust, payer-relevant evidence packages and lead HEOR contributions to global HTA submissions, pricing, reimbursement, and access strategies

• Publications & Scientific Dissemination: Lead the HEOR publication strategy, including congress planning and peer-reviewed publications with Pubs teams, to establish a compelling and credible evidence narrative

• Patient-Centered Outcomes: Drive the development and integration of PROs and other patient-centered endpoints to demonstrate meaningful clinical benefit and differentiation

• Competitive Intelligence & Positioning: Proactively assess and anticipate competitive dynamics (including generics, pipeline entrants, and alternative therapies) to inform evidence strategy and positioning

• Cross-Functional Leadership: Partner closely with Market Access, Medical Affairs, Clinical, Regulatory, and Commercial teams to ensure cohesive and actionable evidence strategies

• Governance & Scientific Integrity: Ensure HEOR activities are conducted with scientific rigor and appropriate governance, maintaining independence of evidence generation while enabling compliant, impactful use

• External Engagement: Oversee external vendors, research partners, and academic collaborations to deliver high-quality, timely evidence outputs

Where You'll Work

This is a onsite role and requires in-office collaboration 2-3x per week in our San Francisco and Palo Alto Offices.

Who You Are

• Advanced degree (PhD, PharmD, MPH, MD, or equivalent) in health economics, outcomes research, epidemiology, or related field

• 10+ years of progressive HEOR experience within biopharma or consulting, including leadership of global programs

• Demonstrated experience supporting product launches and payer strategy development in specialty or rare diseases preferred

• Strong understanding of global HTA frameworks (e.g., NICE, ICER, CADTH, G-BA) and payer evidence requirements

• Proven track record in RWE, economic modeling, and PRO strategy development

Key Competencies

• Strategic, enterprise-level thinker with strong business acumen

• Ability to translate complex evidence into clear, compelling value narratives for diverse stakeholders

• Influential cross-functional leader with a collaborative and proactive mindset

• Strong project leadership and ability to manage multiple priorities in a fast-paced environment

• Executive presence with excellent communication and stakeholder engagement skills

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