Scientist, Oncology Discovery (Multi-Specific Antibody Therapeutics)

Use Your Power for Purpose

At Pfizer, our purpose is to deliver breakthroughs that change patients’ lives. Research and Development plays a critical role in turning cutting-edge science into innovative medicines. Within Pfizer Oncology, we are advancing next‑generation therapeutics to address areas of high unmet medical need for the benefit of patients globally.

What You Will Achieve

As a Scientist in the Discovery Technologies department, you will contribute directly to early‑stage programs focused on discovery of next generation biologics for oncology. Your work will generate high-impact functional screening data that guides antibody discovery decisions, informs lead molecule selection, and enables portfolio progression of transformative therapeutics. In this role you will:

• Design, develop, and execute high-throughput cell‑based functional assays in support of multi‑specific antibody and T cell engager discovery programs

• Perform assays measuring target engagement, cell binding, T cell-mediated cytotoxicity of tumor cells, and T cell activation in the presence of antibody therapeutics; with flow cytometry, luminescence, NanoBRET, and HTRF-based readouts

• Culture and maintain cancer cell lines and primary human T cells in vitro

• Generate and engineer cell lines using molecular cloning, transfection, lentivirus production, and transduction

• Implement and support high‑throughput and semi‑automated assay workflows, including use of Echo liquid handling systems and 384-well plate assay formats

• Analyze, interpret, and clearly communicate experimental data to project teams

• Effectively manage, curate, and structure experimental data to maintain high-quality documentation in electronic lab notebooks and enable integration with an AI-ready environment

• Collaborate effectively within cross‑functional teams spanning tumor biology, protein engineering, automation, and data sciences

Here Is What You Need (Minimum Requirements)

• BS or MS in Biology, Molecular Biology, Cell Biology, Biochemistry, Immunology, or a related discipline

• BA/BS with at least 6 years of experience or MBA/MS with at least 4 years of experience working with antibody-based therapeutics in biotechnology or pharmaceutical settings.

• Hands‑on experience with cell‑based functional assays, particularly those assessing immune cell function (e.g., T cell cytotoxicity assays)

• Demonstrated proficiency in mammalian cell culture, including cancer cell lines and primary immune cells

• Experience executing assays in high‑throughput or semi‑automated formats, including familiarity with laboratory automation and 384-well plate assay formats

• Strong data analysis, organization, and documentation skills

• Excellent written and verbal communication skills and the ability to work productively in cross‑functional teams

• Ability to adapt quickly in a fast‑paced, discovery‑driven research environment

Bonus Points If You Have (Preferred Requirements)

• Experience with molecular biology techniques, including cloning, transfection, lentivirus production, and cell line engineering

•  Familiarity with biochemistry/biophysical analytical techniques used to characterize antibodies and other biologic therapeutics (SPR, HPLC, Mass spectrometry)

• Experience with Genedata platforms (Biologics, Screener) or similar

  

PHYSICAL/MENTAL REQUIREMENTS

• Laboratory work requiring standing or sitting for extended periods

• Ability to work with biological samples and standard laboratory equipment

Other Job Details:

• Last Date to Apply for Job: June 1st, 2026.

• Locations: USA - CA - San Diego (Torrey Heights)

• NOT eligible for Relocation Package

• This position is on premises and requires working onsite.

The annual base salary for this position ranges from $79,400.00 to $132,400.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

Research and Development