Principal Scientist, Protein Production & Engineering

POSITION OVERVIEW:

Disc Medicine is seeking a detailed-oriented and experienced protein biochemist who will join our Innovation team as a Principal Scientist/Associate Director reporting to our Senior Director, Protein production and engineering. This individual will lead the discovery, design, production and/or characterization of biologics at various discovery and development stages, effectively communicate project updates and contribute to the company portfolio with meaningful opportunities for professional development.

RESPONSIBILITIES:

• Provide scientific leadership in the planning, execution, and data interpretation across multiple biologics discovery programs.
• Lead protein engineering strategies for various antigens and biologics (antibodies and multi-specifics) using experimental, computational and structural biology tools
• Design and oversee the protein production and detailed characterization processes to support projects across the Innovation portfolio
• Drive early-stage developability assessment workflows of biologics
• Support mechanisms of action studies through assay development
• Support the selection of lead molecules to advance pipeline programs.
• Critically evaluate scientific literature, synthesize novel hypotheses and design and integrate rigorous experimental strategies to test them.
• Communicate project progress and key findings effectively in cross-functional meetings, ensuring alignment with timelines in a fast-paced, dynamic environment.
• Foster a collaborative and accountable team culture, with a strong emphasis on scientific excellence and continuous improvement.

 REQUIREMENTS:

• Ph.D. in Biochemistry, Structural Biology, Protein engineering, or a related field.
• 10 -12 years of related work experience with at least 5 years of experience working within the biotechnology or pharmaceutical research industry.
• Extensive experience in biologics discovery and protein sciences, including fusion proteins and multi-specific antibodies
• Deep expertise in the characterization of protein structure and function (affinity, stability, developability, etc.)
• Strong background in the use of computational and structural biology tools for protein design is a plus.
• Tech transfer knowledge from Research to Development teams is a plus
• Demonstrated ability to think critically and independently, propose innovative scientific approaches, and apply strong analytical and problem-solving skills to complex biological questions.
• Experience working with contract research organizations (CROs) is preferred.
• Outstanding communication skills—both written and verbal—with the ability to thrive within a collaborative work environment.