Director/Sr. Director, Clinical Pharmacology

<h3><strong><u>Mavericks Wanted</u></strong><u><br></u></h3> <p>When was the last time you achieved the impossible? If that thought feels overwhelming, you might want to pause here, but if it sparks excitement...read on<br> <br>In 2015, we pioneered a “moneyball for biotech” approach, pooling projects and promising early-stage research from academia together under one financial umbrella to reduce risk and unleash innovation. This model allows science and small teams of experts to lead the way. We build bridges to groundbreaking advancements in rare disease, and develop life-changing medicines for patients with unmet needs as fast as humanly possible. <br> <br>Together we define white space, push boundaries and empower people to solve problems. If you're someone who defies convention, join us and work alongside some of the most respected minds in the industry. Together, we'll ask "why not?" and help reengineer the future of biopharma. At BridgeBio, we value curiosity and experimentation—including the ethical & thoughtful use of AI to improve clarity, speed, and quality of work.</p> <h3><strong><u>What You'll Do</u></strong></h3> <p>BridgeBio is seeking an experienced Director/Sr. Director of Clinical Pharmacology to help grow our biologics pipeline, with a primary focus on nonclinical antibody therapeutics. This candidate will serve as the clinical pharmacology leader: shaping nonclinical and clinical strategy, guiding quantitative approaches, and ensuring high-quality execution across nonclinical and clinical development. This is a high-impact leadership role in a fast-moving biotech environment.</p> <h3><strong><u>Responsibilities</u></strong></h3> <ul> <li><span style="color: #222222;">Develop and oversee clinical pharmacology strategy for biologics programs across all stages of development</span></li> <li><span style="color: #222222;">Serve as the CP lead on nonclinical and clinical project teams, providing scientific input on study design, dose selection, PK/PD, and E-R</span></li> <li><span style="color: #222222;">Lead first-in-human dose selection, PK/PD analyses, including NCA, PopPK/PD, and modeling/simulation</span></li> <li><span style="color: #222222;">Collaborate with external CRO partners to deliver quantitative support for program decisions</span></li> <li><span style="color: #222222;">Contribute and author CP content to protocols, SAPs, CSRs, and regulatory submissions (INDs, briefing packages, BLA sections)</span></li> <li><span style="color: #222222;">Partner cross-functionally (Clinical, Regulatory, Stats, Translational, Nonclinical) to integrate CP into development plans</span></li> <li><span style="color: #222222;">Establish and maintain CP standards, templates, and oversight of bioanalytical and modeling vendors</span></li> <li>Present findings internally and externally with scientific meeting abstracts, posters, and manuscripts</li> </ul> <h3><strong><u>Where You'll Work</u></strong></h3> <p>This is a hybrid role and requires in-office collaboration in our Palo Alto office. </p> <h3><strong><u>Who You Are</u></strong></h3> <ul> <li><span style="color: #222222;">PhD, PharmD, or MD in Clinical Pharmacology, PK/PD, Pharmaceutical Sciences, or related field</span></li> <li><span style="color: #222222;">5–10+ years industry experience (Director) or 10+ years (Sr Director) applying CP in drug development</span></li> <li><span style="color: #222222;">Direct experience with monoclonal antibodies/biologics, including immunogenicity and TMDD</span></li> <li><span style="color: #222222;">In depth knowledge in contemporary PK, population PK, QSP modeling concepts, data analysis, and interpretation; demonstrated record in applying these concepts to support pre-clinical and clinical development programs. Proficiency with PK/PD, E-R, and PMx tools (e.g., WinNonlin, NONMEM/Monolix, R).Strong understanding of bioanalytical guidance and GLP/GxP regulations and  regulatory expectations for CP across IND through BLA/MAA</span></li> <li><span style="color: #222222;">Previous experience working on INDs</span></li> <li><span style="color: #222222;">Excellent communication, cross-functional collaboration, and leadership capabilities</span></li> <li><span style="color: #222222;">Vendor management and experience working in fast-paced, matrixed biotech environment</span></li> <li><span style="color: #222222;">You have demonstrated curiosity and adaptability in adopting AI-powered tools and technologies</span></li> </ul> <h3><strong><u>Rewarding Those Who Make the Mission Possible</u></strong></h3> <p>We have high expectations for our team members. We make sure those working hard for patients are rewarded and cared for in return. </p> <p><strong>Financial Benefits:</strong></p> <ul> <li>Market leading compensation </li> <li>401K with 100% employer match on first 3% & 50% on the next 2%</li> <li>Employee stock purchase program</li> <li>Pre-tax commuter benefits</li> <li>Referral program with $2,500 award for hired referrals</li> </ul> <p><strong>Health & Wellbeing:</strong></p> <ul> <li>Comprehensive health care with 100% premiums covered - no cost to you and dependents</li> <li>Mental health support via Spring Health (6 therapy sessions & 6 coaching sessions)</li> <li>Hybrid work model - employees have the autonomy in where and how they do their work </li> <li>Unlimited flexible paid time off - take the time that you need</li> <li>Paid parental leave - 4 months for birthing parents & 2 months for non-birthing parents</li> <li>Flex spending accounts & company-provided group term life & disability </li> <li>Subsidized lunch via Forkable on days worked from our office</li> </ul> <p><strong>Skill Development & Career Paths:</strong></p> <ul> <li>People are part of our growth and success story - from discovery to active drug trials and FDA pipelines, there are endless opportunities for skill development and internal mobility</li> <li>We provide career pathing through regular feedback, continuous education and professional development programs via LinkedIn Learning, LifeLabs, Spring Health & BetterUp Coaching</li> <li>We celebrate strong performance with financial rewards, peer-to-peer recognition, and growth opportunities</li> </ul> <p><span style="color: rgb(255, 255, 255);" data-olk-copy-source="MessageBody">#LI-SG1</span></p><div class="content-pay-transparency"><div class="pay-input"><div class="description"><div> <div>At BridgeBio, we strive to provide a market-competitive total rewards package, including base pay, an annual performance bonus, company equity, and generous health benefits. Below is the anticipated salary range for candidates for this role who will work in California. The final salary offered to a successful candidate will depend on several factors that may include but are not limited to the type and length of experience within the job, type, and length of experience within the industry, educational background, location of residence and performance during the interview process. BridgeBio is a multi-state employer, and this salary range may not reflect positions based in other states.</div> </div></div><div class="title">Salary</div><div class="pay-range"><span>$215,000</span><span class="divider">—</span><span>$290,000 USD</span></div></div></div>