Director, Imaging Biomarkers

<div class="content-intro"><h3>Company Overview:</h3> <p>Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at <a href="https://www.dyne-tx.com/">https://www.dyne-tx.com/</a>, and follow us on <a href="https://x.com/dyne_tx">X</a>, <a href="https://www.linkedin.com/company/dynetx/">LinkedIn</a> and <a href="https://www.facebook.com/DyneTherapeutic/">Facebook</a>.</p></div><p><strong>Role Summary:</strong></p> <p data-ccp-border-bottom="0px none #000000" data-ccp-padding-bottom="0px" data-ccp-border-between="0px none #000000" data-ccp-padding-between="0px"><span data-contrast="none"><span data-ccp-parastyle="Normal (Web)">The Director of Imaging Biomarkers lead</span><span data-ccp-parastyle="Normal (Web)">s</span><span data-ccp-parastyle="Normal (Web)"> the development and execution of innovative imaging strategies across Dyne’s therapeutic programs. </span><span data-ccp-parastyle="Normal (Web)">This </span><span data-ccp-parastyle="Normal (Web)">pivotal </span><span data-ccp-parastyle="Normal (Web)">role </span><span data-ccp-parastyle="Normal (Web)">will</span><span data-ccp-parastyle="Normal (Web)"> ensur</span><span data-ccp-parastyle="Normal (Web)">e</span><span data-ccp-parastyle="Normal (Web)"> that imaging biomarker strategies are scientifically rigorous, clinically relevant, and condu</span><span data-ccp-parastyle="Normal (Web)">cive to robust therapeutic development. The person in this</span><span data-ccp-parastyle="Normal (Web)"> role focuses on enhancing the understanding of disease </span><span data-ccp-parastyle="Normal (Web)">mechanisms</span><span data-ccp-parastyle="Normal (Web)">, </span><span data-ccp-parastyle="Normal (Web)">patient populations, </span><span data-ccp-parastyle="Normal (Web)">evaluating therapeutic efficacy, and supporting clinical </span><span data-ccp-parastyle="Normal (Web)">trial</span><span data-ccp-parastyle="Normal (Web)"> designs through innovative imaging approaches. </span><span data-ccp-parastyle="Normal (Web)">This role is cri</span><span data-ccp-parastyle="Normal (Web)">tical to linking early phase research to clinical development, </span><span data-ccp-parastyle="Normal (Web)">providing</span><span data-ccp-parastyle="Normal (Web)"> essential insights that drive decision making. </span><span data-ccp-parastyle="Normal (Web)">The person in this role </span><span data-ccp-parastyle="Normal (Web)">leverages</span><span data-ccp-parastyle="Normal (Web)"> their </span><span data-ccp-parastyle="Normal (Web)">expertise</span><span data-ccp-parastyle="Normal (Web)"> in various imaging modalities to develop novel biomarker applications that assess therapeutic efficacy, drive patient-centric trial designs, and </span><span data-ccp-parastyle="Normal (Web)">facilitate</span><span data-ccp-parastyle="Normal (Web)"> regulatory approval processes. </span><span data-ccp-parastyle="Normal (Web)">This role combines scientific depth with strategic vision, driving the discovery, validation, and application of advanced imaging modalities to enable precision medicine and accelerate drug development. The </span><span data-ccp-parastyle="Normal (Web)">person in this role</span><span data-ccp-parastyle="Normal (Web)"> serve</span><span data-ccp-parastyle="Normal (Web)">s</span><span data-ccp-parastyle="Normal (Web)"> as a trusted expert and collaborative leader, fostering innovation and ensuring scientific rigor in both preclinical and clinical settings</span><span data-ccp-parastyle="Normal (Web)">.</span><span data-ccp-parastyle="Normal (Web)"> </span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335557856":16777215,"335559740":276,"335572071":0,"335572072":0,"335572073":4278190080,"335572075":0,"335572076":0,"335572077":4278190080,"335572079":0,"335572080":0,"335572081":4278190080,"335572083":0,"335572084":0,"335572085":4278190080,"335572087":0,"335572088":0,"335572089":4278190080,"469789798":"none","469789802":"none","469789806":"none","469789810":"none","469789814":"none"}"> </span></p> <p data-ccp-border-bottom="0px none #000000" data-ccp-padding-bottom="0px" data-ccp-border-between="0px none #000000" data-ccp-padding-between="0px"><span data-contrast="none">This role is based in Waltham, MA.  </span><span data-ccp-props="{}"> </span></p> <p data-ccp-border-between="0px none #000000" data-ccp-padding-between="0px"><strong><span data-contrast="none"><span data-ccp-parastyle="Body">Primary Responsibilities</span><span data-ccp-parastyle="Body"> Include</span><span data-ccp-parastyle="Body">:</span></span></strong><span data-ccp-props="{"335559739":120}"> </span></p> <ul> <li><span data-contrast="none"><span data-ccp-parastyle="Body">Collaborate with cross-</span><span data-ccp-parastyle="Body">functional</span><span data-ccp-parastyle="Body"> teams including clinical development, biostatistics, and regulatory affairs to </span><span data-ccp-parastyle="Body">ensure</span><span data-ccp-parastyle="Body"> that imaging biomarkers are effectively integrated into clinical trial protocols</span></span><span data-ccp-props="{"335559739":120}"> </span></li> <li><span data-contrast="none"><span data-ccp-parastyle="Body">Enable the delivery of high-quality data supporting both internal decision making and external communications with stakeholders, including regulatory authorities </span></span><span data-ccp-props="{"335559739":120}"> </span></li> <li><span data-contrast="none"><span data-ccp-parastyle="Body">Define and execute the imaging biomarker strategy aligned with clinical and translational objectives</span></span><span data-ccp-props="{"335559739":120}"> </span></li> <li><span data-contrast="none"><span data-ccp-parastyle="Body">Serve as the subject matter expert for imaging biomarkers across </span><span data-ccp-parastyle="Body">pre-clinical</span><span data-ccp-parastyle="Body"> and clinical programs</span></span><span data-ccp-props="{"335559739":120}"> </span></li> <li><span data-contrast="none"><span data-ccp-parastyle="Body">Lead the </span><span data-ccp-parastyle="Body">development</span><span data-ccp-parastyle="Body">, validation, and qualification of imaging biomarkers for disease characterization, patient stratification, and pharmacodynamic assessment</span></span><span data-ccp-props="{"335559739":120}"> </span></li> <li><span data-contrast="none"><span data-ccp-parastyle="Body">Partner with Clinical Development, Translational Biomarkers, Biostatistics, Data Management and Regulatory teams to integrate imaging biomarkers into Dyne clinical trials</span></span><span data-ccp-props="{"335559739":120}"> </span></li> <li><span data-contrast="none"><span data-ccp-parastyle="Body">Evaluate and implement</span><span data-ccp-parastyle="Body"> </span><span data-ccp-parastyle="Body">cutting-edge</span><span data-ccp-parastyle="Body"> imaging technologies (e.g., MRI, PET, CT, ultrasound, optical imaging)</span></span><span data-ccp-props="{"335559739":120}"> </span></li> <li><span data-contrast="none"><span data-ccp-parastyle="Body">Ensure compliance with regulatory standards for imaging biomarker development and qualification</span></span><span data-ccp-props="{"335559739":120}"> </span></li> <li><span data-contrast="none"><span data-ccp-parastyle="Body">Collaborate with external imaging CROs, academic institutions, and technology vendors to deploy imaging biomarkers into Dyne clinical trials</span></span><span data-ccp-props="{"335559739":120}"> </span></li> <li><span data-contrast="none"><span data-ccp-parastyle="Body">Oversee vendor selection and budget management for imaging-related activities</span></span><span data-ccp-props="{"335559739":120}"> </span></li> <li><span data-contrast="none"><span data-ccp-parastyle="Body">Manage imaging biomarker operations in clinical studies including protocol development, support site training, and data quality assurance</span></span><span data-ccp-props="{"335559739":120}"> </span></li> <li><span data-contrast="none"><span data-ccp-parastyle="Body">Foster a culture of innovation and scientific rigor</span></span><span data-ccp-props="{"335559739":120}"> </span></li> </ul> <p data-ccp-border-between="0px none #000000" data-ccp-padding-between="0px"><strong><span data-contrast="none"><span data-ccp-parastyle="Body">Education and Skill</span><span data-ccp-parastyle="Body">s</span><span data-ccp-parastyle="Body"> Requirements</span><span data-ccp-parastyle="Body">:</span></span></strong><span data-ccp-props="{"335559739":120}"> </span></p> <ul> <li><span data-contrast="none"><span data-ccp-parastyle="Body">Ph.D., M.D., or equivalent in Biomedical </span><span data-ccp-parastyle="Body">Engineering, </span><span data-ccp-parastyle="Body">Medical Physics</span><span data-ccp-parastyle="Body">, Radiology, or related </span><span data-ccp-parastyle="Body">scientific disciplines</span></span><span data-ccp-props="{"335559739":120}"> </span></li> <li><span data-contrast="none"><span data-ccp-parastyle="Body">10+ years of experience in imaging biomarker development within pharma, biotech, or academic research</span></span><span data-ccp-props="{"335559739":120}"> </span></li> <li><span data-contrast="none"><span data-ccp-parastyle="Body">Blend of technical knowledge, scientific acumen, and strategic vision to foster collaborations with academic institutions, industry partners, and clinical </span><span data-ccp-parastyle="Body">experts</span><span data-ccp-parastyle="Body"> </span></span><span data-ccp-props="{"335559739":120}"> </span></li> <li><span data-contrast="none"><span data-ccp-parastyle="Body">Deep scientific </span><span data-ccp-parastyle="Body">expertise</span><span data-ccp-parastyle="Body"> in at least one major imaging modality </span><span data-ccp-parastyle="Body">(</span><span data-ccp-parastyle="Body">preferably MRI</span><span data-ccp-parastyle="Body">)</span><span data-ccp-parastyle="Body"> and a strong understanding of image acquisition, processing, and analysis</span></span><span data-ccp-props="{"335559739":120}"> </span></li> <li><span data-contrast="none"><span data-ccp-parastyle="Body">Proven </span><span data-ccp-parastyle="Body">track record</span><span data-ccp-parastyle="Body"> in applying imaging biomarkers in clinical trials and regulatory submissions</span></span><span data-ccp-props="{"335559739":120}"> </span></li> <li><span data-contrast="none"><span data-ccp-parastyle="Body">Expertise</span><span data-ccp-parastyle="Body"> </span><span data-ccp-parastyle="Body">in </span><span data-ccp-parastyle="Body">quantitative imaging method</span><span data-ccp-parastyle="Body">ologies</span><span data-ccp-parastyle="Body">, image analysis software, and </span><span data-ccp-parastyle="Body">imaging </span><span data-ccp-parastyle="Body">data interpretation</span></span><span data-ccp-props="{"335559739":120}"> </span></li> <li><span data-contrast="none"><span data-ccp-parastyle="Body">Strong leadership and project management skills with ability to influence across functions</span></span><span data-ccp-props="{"335559739":120}"> </span></li> <li><span data-contrast="none"><span data-ccp-parastyle="Body">Excellent communication and presentation skills</span></span><span data-ccp-props="{"335559739":120}"> </span></li> </ul> <p data-ccp-border-between="0px none #000000" data-ccp-padding-between="0px"><strong><span data-contrast="none"><span data-ccp-parastyle="Normal (Web)">Preferred Experience:</span></span></strong><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335557856":16777215,"335559739":120,"335559740":360,"335572071":0,"335572072":0,"335572073":4278190080,"335572075":0,"335572076":0,"335572077":4278190080,"335572079":0,"335572080":0,"335572081":4278190080,"335572083":0,"335572084":0,"335572085":4278190080,"335572087":0,"335572088":0,"335572089":4278190080,"469789798":"none","469789802":"none","469789806":"none","469789810":"none","469789814":"none"}"> </span></p> <ul> <li><span data-contrast="none"><span data-ccp-parastyle="Body">Familiarity with AI/ML approaches for image analysis</span><span data-ccp-parastyle="Body"> to improve efficiency, accuracy, and uncover complex patterns in imaging data</span></span><span data-ccp-props="{"335559739":120}"> </span></li> <li><span data-contrast="none"><span data-ccp-parastyle="Body">Understanding and implementation of digital biomarkers using wearables, sensors, or other digital health technologies</span></span><span data-ccp-props="{"335559739":120}"> </span></li> <li><span data-contrast="none"><span data-ccp-parastyle="Body">Knowledge of disease-specific imaging biomarkers (</span><span data-ccp-parastyle="Body">e.g., neurology</span><span data-ccp-parastyle="Body">, cardiology</span><span data-ccp-parastyle="Body"> or neuromuscular</span><span data-ccp-parastyle="Body">)</span></span><span data-ccp-props="{"335559739":120}"> </span></li> </ul><div class="content-pay-transparency"><div class="pay-input"><div class="title">MA Pay Range</div><div class="pay-range"><span>$196,000</span><span class="divider">—</span><span>$240,000 USD</span></div></div></div><div class="content-conclusion"><p> </p> <p>The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills.</p> <p>The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.  Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.</p> <p class="Body"><em><span style="font-family: 'Arial',sans-serif; color: #626262;">Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.</span></em></p></div>