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Wrinkle

1
Pipeline Programs
6
Companies
11
Clinical Trials
3 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
0
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

6 companies ranked by most advanced pipeline stage

Fitzpatrick Company
Fitzpatrick CompanyON - Waterloo
3 programs
1
SkinvivePhase 21 trial
Restylane® SilkN/A1 trial
Restylane® SilkN/A1 trial
Active Trials
NCT03461198Unknown20Est. Aug 2020
NCT03742479Unknown20Est. Feb 2020
NCT07221461Not Yet Recruiting24Est. Mar 2026
Cytrellis Biosystems
3 programs
MCDN/A1 trial
ellacor® Micro-Coring procedureN/A1 trial
micro-excisional skin removal with coring needleN/A1 trial
Active Trials
NCT03793348Recruiting35Est. Aug 2019
NCT06502470Completed3Est. May 2024
NCT03228641Completed45Est. Aug 2017
Galderma
GaldermaTX - Dallas
2 programs
Defyne Treatment in Nasolabial FoldN/A1 trial
GAL1906N/A1 trial
Active Trials
NCT06351293Completed15Est. Apr 2025
NCT04717934Completed211Est. Jun 2025
ReVision Therapeutics
ReVision TherapeuticsNJ - Ridgewood
1 program
Gentle Cleansing Lotion, Revision SkincareN/A1 trial
Active Trials
NCT04911374Completed45Est. Feb 2021
Innate Pharma
Innate PharmaFrance - Marseille
1 program
Innea, Innea AquaN/A1 trial
Active Trials
NCT07331181Recruiting55Est. Dec 2026
Bausch Health
Bausch HealthQUEBEC, Quebec, Canada
1 program
Thermage FLXN/A1 trial
Active Trials
NCT07187297Recruiting164Est. Mar 2027

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
Fitzpatrick CompanySkinvive
Bausch HealthThermage FLX
GaldermaGAL1906
Cytrellis Biosystemsellacor® Micro-Coring procedure
GaldermaDefyne Treatment in Nasolabial Fold
Innate PharmaInnea, Innea Aqua
ReVision TherapeuticsGentle Cleansing Lotion, Revision Skincare
Fitzpatrick CompanyRestylane® Silk
Fitzpatrick CompanyRestylane® Silk
Cytrellis BiosystemsMCD
Cytrellis Biosystemsmicro-excisional skin removal with coring needle

Clinical Trials (11)

Total enrollment: 637 patients across 11 trials

Assess Impact of Microdroplet Hyaluronic Acid Filler on Skin Quality in Patients on Glucagon-like Peptide-1 Agonists

Start: Nov 2025Est. completion: Mar 202624 patients
Phase 2Not Yet Recruiting

A Prospective Controlled Study to Evaluate the Safety and Effectiveness of Thermage® FLX Radiofrequency Treatment

Start: Oct 2025Est. completion: Mar 2027164 patients
N/ARecruiting

Main Study: A Study to Evaluate the Effectiveness and Safety of GAL1906 for Correction of Wrinkles in the décolletage Area Sub-study: A Follow-up Study to Evaluate the Analysis of Mammograms Following Treatment for Correction of Wrinkles in Décolletage Area in the Investigational Study 43USRV1906

Start: Feb 2025Est. completion: Jun 2025211 patients
N/ACompleted
NCT06502470Cytrellis Biosystemsellacor® Micro-Coring procedure

Healing Study of Fractional Skin Resurfacing and Tissue Histopathology After Ellacor Treatment

Start: Apr 2024Est. completion: May 20243 patients
N/ACompleted
NCT06351293GaldermaDefyne Treatment in Nasolabial Fold

A Comparative Analysis of Two Hyaluronic Acid Fillers for Nasolabial Fold Correction

Start: Feb 2024Est. completion: Apr 202515 patients
N/ACompleted
NCT07331181Innate PharmaInnea, Innea Aqua

Evaluation of Performance and Safety of INNEA and INNEA AQUA for the Treatment of Cheek and décolletage Wrinkles

Start: Jun 2023Est. completion: Dec 202655 patients
N/ARecruiting
NCT04911374ReVision TherapeuticsGentle Cleansing Lotion, Revision Skincare

An Open-Label Clinical Study to Evaluate the Efficacy of a Face Cream and Eye Cream

Start: Sep 2020Est. completion: Feb 202145 patients
N/ACompleted

Micro-injections of Transparent Hyaluronic Acid Gel (Restylane® Silk) for Rejuvenation of the Aging Cheek

Start: Feb 2019Est. completion: Aug 202020 patients
N/AUnknown

Restylane Silk Microinjections to Cheeks

Start: Feb 2019Est. completion: Feb 202020 patients
N/AUnknown

Study to Evaluate the Safety and Efficacy of the Cytrellis Micro-Coring Device for the Treatment of Moderate to Severe Facial Wrinkles

Start: Nov 2018Est. completion: Aug 201935 patients
N/ARecruiting
NCT03228641Cytrellis Biosystemsmicro-excisional skin removal with coring needle

Evaluation of Safety and Efficacy of Micro-coring Device for Treatment of Facial Wrinkles and Skin Laxity

Start: Jun 2016Est. completion: Aug 201745 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

3 actively recruiting trials targeting 637 patients
6 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.