Skip to main content

Ventricular Fibrillation

1
Pipeline Programs
8
Companies
17
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
1
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

8 companies ranked by most advanced pipeline stage

Medtronic
MedtronicNJ - Phillipsburg
2 programs
1
Cardiac defibrillation at high energy vs low energy levelsPhase 31 trial
Left Ventricular Capture Management StudyN/A1 trial
Active Trials
NCT01089634Completed151Est. Dec 2010
NCT00429611Unknown600Est. Dec 2009
Boston Scientific
Boston ScientificCA - Valencia
5 programs
EMBLEM S-ICD SystemN/A1 trial
Implantable defibrillatorN/A1 trial
Implantable defibrillatorN/A1 trial
Subcutaneous Implantable DefibrillatorN/A1 trial
commercially released subcutaneous implantable cardioverter defibrillatorN/A1 trial
Active Trials
NCT02433379Completed1,173Est. Dec 2019
NCT00800384Completed2,500Est. May 2014
NCT00661037Completed2,120Est. Sep 2011
+2 more trials
Biotronik
BiotronikGermany - Berlin
4 programs
Home Monitoring provided by Biotronik ICD and CRT-D devicesN/A1 trial
SD01 ICD leadN/A1 trial
ICD or CRT-D with Home Monitoring feature deactivatedPHASE_41 trial
Implantable Cardioverter DefibrillatorPHASE_41 trial
Active Trials
NCT00776087Terminated409Est. Oct 2016
NCT02014675Completed280Est. Sep 2024
NCT00538356Completed720Est. Aug 2013
+1 more trials
AtaCor Medical
AtaCor MedicalCA - San Clemente
1 program
AtaCor EV-ICD LeadN/A3 trials
Active Trials
NCT05791032Completed21Est. Mar 2024
NCT05352776Completed18Est. Oct 2022
NCT05099289Completed18Est. Mar 2022
Philips
PhilipsNetherlands - Amsterdam
1 program
Automated external defibrillatorN/A1 trial
Active Trials
NCT00535106Completed900Est. Jun 2009
Heidelberg Pharma
Heidelberg PharmaGermany - Ladenburg
1 program
EEGN/A1 trial
Active Trials
NCT00176176Unknown30
Rhythm Pharmaceuticals
1 program
Left Ventricular Capture Management StudyN/A
PEEL Therapeutics
PEEL TherapeuticsUT - Salt Lake City
1 program
Vector change defibrillationN/A1 trial
Active Trials
NCT03249948CompletedEst. Mar 2020

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
BiotronikICD or CRT-D with Home Monitoring feature deactivated
BiotronikImplantable Cardioverter Defibrillator
MedtronicCardiac defibrillation at high energy vs low energy levels
AtaCor MedicalAtaCor EV-ICD Lead
AtaCor MedicalAtaCor EV-ICD Lead
AtaCor MedicalAtaCor EV-ICD Lead
Boston Scientificcommercially released subcutaneous implantable cardioverter defibrillator
PEEL TherapeuticsVector change defibrillation
Boston ScientificEMBLEM S-ICD System
BiotronikSD01 ICD lead
Boston ScientificImplantable defibrillator
BiotronikHome Monitoring provided by Biotronik ICD and CRT-D devices
Boston ScientificImplantable defibrillator
MedtronicLeft Ventricular Capture Management Study
Boston ScientificSubcutaneous Implantable Defibrillator

Showing 15 of 16 trials with date data

Clinical Trials (17)

Total enrollment: 9,192 patients across 17 trials

NCT00538356BiotronikICD or CRT-D with Home Monitoring feature deactivated

Influence of Home Monitoring on the Clinical Status of Heart Failure Patients With an Impaired Left Ventricular Function

Start: Jul 2007Est. completion: Aug 2013720 patients
Phase 4Completed
NCT00401466BiotronikImplantable Cardioverter Defibrillator

Remote Follow-up of Patients Receiving Implantable Cardioverter Defibrillator for Prophylactic Therapy

Start: Jan 2004Est. completion: Jul 2008155 patients
Phase 4Completed
NCT00429611MedtronicCardiac defibrillation at high energy vs low energy levels

High Low Biphasic Energy Defibrillation (HiLoBED)

Start: Nov 2004Est. completion: Dec 2009600 patients
Phase 3Unknown
NCT00176176Heidelberg PharmaEEG

Investigation of Cognitive Function Before and After Induced Ventricular Fibrillation in Electrophysiological (EP) Study

30 patients
N/AUnknown
NCT05791032AtaCor MedicalAtaCor EV-ICD Lead

Sub Chronic Evaluation for ATP With an Extravascular Placed ICD Lead (STEP ICD) Study

Start: Sep 2023Est. completion: Mar 202421 patients
N/ACompleted
NCT05352776AtaCor MedicalAtaCor EV-ICD Lead

Sensing and Defibrillation With a Commercially Available ICD Coupled With a Parasternal Extravascular Lead (SECURE EV) Study

Start: May 2022Est. completion: Oct 202218 patients
N/ACompleted
NCT05099289AtaCor MedicalAtaCor EV-ICD Lead

Parasternal Access for ShockS and Pacing With an acUtely Placed Less-invasive Lead for EV-ICD (PASS PULL EV-ICD) Study

Start: Nov 2021Est. completion: Mar 202218 patients
N/ACompleted
NCT03802110Boston Scientificcommercially released subcutaneous implantable cardioverter defibrillator

Acute Feasibility Investigation of a New S-ICD Electrode

Start: Nov 2018Est. completion: Apr 202242 patients
N/ACompleted
NCT03249948PEEL TherapeuticsVector change defibrillation

DOuble SEquential External Defibrillation for Refractory VF Pilot Study

Start: Mar 2018Est. completion: Mar 2020
N/ACompleted
NCT02433379Boston ScientificEMBLEM S-ICD System

Understanding Outcomes With the EMBLEM™ S-ICD in Primary Prevention Patients With Low Ejection Fraction

Start: Jun 2015Est. completion: Dec 20191,173 patients
N/ACompleted
NCT02014675BiotronikSD01 ICD lead

SD01 Registry (SD01 ICD Lead)

Start: Mar 2014Est. completion: Sep 2024280 patients
N/ACompleted
NCT00800384Boston ScientificImplantable defibrillator

Shockless Implant Evaluation

Start: Jan 2009Est. completion: May 20142,500 patients
N/ACompleted
NCT00776087BiotronikHome Monitoring provided by Biotronik ICD and CRT-D devices

European Health Economic Trial on Home Monitoring in ICD and CRT-D Patients (EuroEco)

Start: Oct 2008Est. completion: Oct 2016409 patients
N/ATerminated
NCT00661037Boston ScientificImplantable defibrillator

SAFEty of Two Strategies of ICD Management at Implantation

Start: Mar 2008Est. completion: Sep 20112,120 patients
N/ACompleted
NCT01089634MedtronicLeft Ventricular Capture Management Study

Left Ventricular Capture Management Study

Start: Oct 2007Est. completion: Dec 2010151 patients
N/ACompleted
NCT00399217Boston ScientificSubcutaneous Implantable Defibrillator

Further Acute Research of a Subcutaneous Implantable Defibrillator (S-ICD) System

Start: Nov 2006Est. completion: Jun 200855 patients
N/ACompleted
NCT00535106PhilipsAutomated external defibrillator

SmartCPR Trial: An Analysis of a Waveform-Based Automated External Defibrillation (AED) Algorithm on Survival From Out-of-Hospital Ventricular Fibrillation

Start: May 2006Est. completion: Jun 2009900 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
8 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.