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Varicose Veins

11
Pipeline Programs
8
Companies
17
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
2
1
4
3
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

8 companies ranked by most advanced pipeline stage

Boston Scientific
Boston ScientificCA - Valencia
9 programs
1
2
1
2
2
Varithena®Phase 41 trial
Varithena®Phase 41 trial
Polidocanol injectable foamPhase 31 trial
polidocanol injectable foam, 0.125%Phase 31 trial
VarisolvePhase 2/31 trial
+4 more programs
Active Trials
NCT01200199Completed45Est. Aug 2011
NCT01428076Completed21Est. Jan 2012
NCT00442364Completed60Est. Aug 2009
+6 more trials
Biocorp
BiocorpFrance - Issoire
1 program
1
Mepivacaine chlorhydrate 2% in Sodium Bicarbonate 1.4%Phase 41 trial
Active Trials
NCT01611324Completed100Est. Dec 2012
EMS
EMSBrazil - Hortolândia
2 programs
2
TOPIC MUCOPOLYSACCHARIDE POLYSULFATE 5MG/GPhase 31 trial
TOPIC MUCOPOLYSACCHARIDE POLYSULFATE CREAM 5MG/GPhase 31 trial
Active Trials
NCT01203397Withdrawn0Est. Feb 2015
NCT01426035Withdrawn0Est. Feb 2015
Medtronic
MedtronicNJ - Phillipsburg
1 program
Chart reviewN/A1 trial
Active Trials
NCT04006184Completed547Est. Aug 2019
Theraclion
TheraclionFrance - Malakoff
1 program
Sonovein 2N/A1 trial
Active Trials
NCT04280679Completed22Est. Sep 2020
AngioDynamics
AngioDynamicsChina - Hong Kong
1 program
VNUS RF ClosureFASTN/A1 trial
Active Trials
NCT01173419Withdrawn0Est. Feb 2012
City Therapeutics
City TherapeuticsMA - Cambridge
1 program
class I compression stockings of the RAL-GZ 387 standard: 1 month usingN/A1 trial
Active Trials
NCT06913764CompletedEst. Jul 2025
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
1 program
elastic bandageN/A1 trial
Active Trials
NCT05840991Unknown360Est. Dec 2023

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Boston ScientificVarithena®
Boston ScientificVarithena®
BiocorpMepivacaine chlorhydrate 2% in Sodium Bicarbonate 1.4%
EMSTOPIC MUCOPOLYSACCHARIDE POLYSULFATE CREAM 5MG/G
EMSTOPIC MUCOPOLYSACCHARIDE POLYSULFATE 5MG/G
Boston ScientificPolidocanol injectable foam
Boston Scientificpolidocanol injectable foam, 0.125%
Boston ScientificVarisolve
Boston ScientificPolidocanol Endovenous Microfoam 0.125%
Boston ScientificPolidocanol
Boston ScientificPolidocanol Endovenous Microfoam
City Therapeuticsclass I compression stockings of the RAL-GZ 387 standard: 1 month using
UNION therapeuticselastic bandage
TheraclionSonovein 2
MedtronicChart review

Showing 15 of 17 trials with date data

Clinical Trials (17)

Total enrollment: 1,840 patients across 17 trials

Varithena Versus Endothermal Ablation of the Great Saphenous Vein (VERITAS)

Start: Feb 2023Est. completion: Apr 202443 patients
Phase 4Terminated

COMFORT: A Multicenter, Open-label, Randomized, Crossover Study

Start: May 2015Est. completion: Mar 201635 patients
Phase 4Completed
NCT01611324BiocorpMepivacaine chlorhydrate 2% in Sodium Bicarbonate 1.4%

Painless Local Infiltration Anesthesia

Start: May 2012Est. completion: Dec 2012100 patients
Phase 4Completed
NCT01426035EMSTOPIC MUCOPOLYSACCHARIDE POLYSULFATE CREAM 5MG/G

Safety And Efficacy Study Of Topic Mucopolysaccharide Polysulfate Cream In The Superficial Varicose Veins Treatment

Start: Sep 2014Est. completion: Feb 20150
Phase 3Withdrawn
NCT01203397EMSTOPIC MUCOPOLYSACCHARIDE POLYSULFATE 5MG/G

Safety And Efficacy Study Of Topic Mucopolysaccharide Polysulfate In The Superficial Varicose Veins Treatment

Start: Sep 2014Est. completion: Feb 20150
Phase 3Withdrawn
NCT01072877Boston ScientificPolidocanol injectable foam

Efficacy and Safety Study of Polidocanol Injectable Foam for the Treatment of Saphenofemoral Junction (SFJ) Incompetence

Start: Dec 2010Est. completion: Nov 2012279 patients
Phase 3Completed
NCT01231373Boston Scientificpolidocanol injectable foam, 0.125%

Polidocanol Endovenous Microfoam (PEM) Versus Vehicle for the Treatment of Saphenofemoral Junction (SFJ) Incompetence

Start: Nov 2010Est. completion: Aug 2014235 patients
Phase 3Completed

Randomized, Single Blind, Placebo Controlled, to Evaluate Efficacy and Safety of Polidocanol Injectable Foam for Treatment of Symptomatic, Visible Varicose Veins With SFJ Incompetence

Start: Oct 2008Est. completion: Aug 200977 patients
Phase 2/3Completed
NCT00928421Boston ScientificPolidocanol Endovenous Microfoam 0.125%

An Open-label, Single-dose Pilot Study to Evaluate Varisolve® (Polidocanol Endovenous Microfoam (PEM)) 0.125% [0.2%] for Varicose Veins

Start: Jun 2009Est. completion: Jan 201016 patients
Phase 2Completed

Safety Study of Varisolve® Procedure for Treatment of Varicose Veins in Patients With Right-to-left Cardiac Shunt

Start: Mar 2007Est. completion: Aug 200960 patients
Phase 2Completed
NCT01428076Boston ScientificPolidocanol Endovenous Microfoam

Pharmacokinetic Study of Polidocanol Endovenous Microfoam (PEM)

Start: Aug 2011Est. completion: Jan 201221 patients
Phase 1Completed
NCT06913764City Therapeuticsclass I compression stockings of the RAL-GZ 387 standard: 1 month using

First- or Second- Class Compression Hosiery After Endovenous Laser With Sclerotherapy and Ambulatory Phlebectomy

Start: Apr 2025Est. completion: Jul 2025
N/ACompleted

Effect of Short-term Compression Therapy After Thermal Ablation for Varicose Veins

Start: May 2023Est. completion: Dec 2023360 patients
N/AUnknown

Treatment of Insufficient Superficial and Perforatring Veins of the Lower Limb Using HIFU

Start: Mar 2020Est. completion: Sep 202022 patients
N/ACompleted

Retrospective Review of Saphenous Vein Incompetence: Venaseal Versus Endovenous Thermal Ablation

Start: Jun 2019Est. completion: Aug 2019547 patients
N/ACompleted
NCT01200199Boston ScientificValidity of Electronic Diary for Monitoring Varicose Veins Symptoms

Validity of Electronic Diary for Monitoring Varicose Veins Symptoms

Start: Nov 2010Est. completion: Aug 201145 patients
N/ACompleted
NCT01173419AngioDynamicsVNUS RF ClosureFAST

Comparison Study for Safety and Efficacy of Two Devices for the Treatment of the Great Saphenous Vein

Start: Jul 2010Est. completion: Feb 20120
N/AWithdrawn

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

4 late-stage (Phase 3) programs, potential near-term approvals
8 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.