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Tricuspid Valve Insufficiency

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Pipeline Programs
6
Companies
6
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
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0
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Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

5 companies ranked by most advanced pipeline stage

Edwards Lifesciences
2 programs
Cardioband TricuspidN/A1 trial
Edwards PASCAL Transcatheter Valve Repair SystemN/A1 trial
Active Trials
NCT02981953Completed40Est. Nov 2019
NCT04614402Active Not Recruiting300Est. Mar 2028
Abbott
AbbottABBOTT PARK, IL
2 programs
Tricuspid Valve Repair SystemN/A1 trial
Tricuspid valve repair or replacementN/A
Active Trials
NCT03227757Completed98Est. May 2024
Medtronic
MedtronicNJ - Phillipsburg
2 programs
Tricuspid valve repairN/A1 trial
Tricuspid valve repair or replacementN/A1 trial
Active Trials
NCT01532921Completed85Est. Jan 2016
NCT03775759Completed71Est. Feb 2023
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
1 program
Tricuspid Valve Replacement SystemN/A1 trial
Active Trials
NCT04436653Recruiting150Est. Jun 2026
Rhythm Pharmaceuticals
1 program
Tricuspid valve repairN/A

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
Edwards LifesciencesEdwards PASCAL Transcatheter Valve Repair System
UNION therapeuticsTricuspid Valve Replacement System
MedtronicTricuspid valve repair or replacement
AbbottTricuspid Valve Repair System
Edwards LifesciencesCardioband Tricuspid
MedtronicTricuspid valve repair

Clinical Trials (6)

Total enrollment: 744 patients across 6 trials

NCT04614402Edwards LifesciencesEdwards PASCAL Transcatheter Valve Repair System

Transcatheter Repair of Tricuspid Regurgitation With Edwards PASCAL Transcatheter Valve Repair System

Start: Jan 2021Est. completion: Mar 2028300 patients
N/AActive Not Recruiting
NCT04436653UNION therapeuticsTricuspid Valve Replacement System

THE TRAVEL TRIAL: Transcatheter Right Atrial-ventricular Valve rEplacement With LuX-Valve

Start: Jun 2020Est. completion: Jun 2026150 patients
N/ARecruiting
NCT03775759MedtronicTricuspid valve repair or replacement

Treatment of Tricuspid Valve Regurgitation in Patients Undergoing Left Ventricular Assist Device Implantation Study

Start: Aug 2018Est. completion: Feb 202371 patients
N/ACompleted
NCT03227757AbbottTricuspid Valve Repair System

TRILUMINATE Study With Abbott Transcatheter Clip Repair System in Patients With Moderate or Greater TR

Start: Aug 2017Est. completion: May 202498 patients
N/ACompleted
NCT02981953Edwards LifesciencesCardioband Tricuspid

TRI-REPAIR: TrIcuspid Regurgitation RePAIr With CaRdioband Transcatheter System

Start: Oct 2016Est. completion: Nov 201940 patients
N/ACompleted
NCT01532921MedtronicTricuspid valve repair

EASE TRICUSPID Expertise-based Assessment Study on Clinical Efficacy of Contour 3D® in TRICUSPID Valve Annuloplasty

Start: Jan 2011Est. completion: Jan 201685 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 actively recruiting trials targeting 744 patients
6 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.