Syncope

2
Pipeline Programs
4
Companies
7
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
0
2
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

4 companies ranked by most advanced pipeline stage

Rhythm Pharmaceuticals
3 programs
2
Dual chamber pacemekerPhase 41 trial
Use of an Implantable Loop RecorderPhase 41 trial
Insertable Cardiac Monitor ImplantN/A1 trial
Active Trials
NCT01965899Completed151Est. Sep 2015
NCT00359203Completed511Est. Nov 2012
NCT00170261Completed100Est. Sep 2006
Biotronik
BiotronikGermany - Berlin
2 programs
BIO|STREAM.ICM FranceN/A1 trial
DDD-CLSN/A1 trial
Active Trials
NCT04206774Completed92Est. Dec 2021
NCT02324920Completed128Est. Jul 2020
Abbott
AbbottABBOTT PARK, IL
1 program
ConfirmRxN/A1 trial
Active Trials
NCT03803969Completed100Est. Jul 2020
Zoll
ZollCA - San Jose
1 program
Short Term Wearable DefibrillatorN/A1 trial
Active Trials
NCT02188147CompletedEst. Apr 2020

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Rhythm PharmaceuticalsDual chamber pacemeker
Rhythm PharmaceuticalsUse of an Implantable Loop Recorder
BiotronikBIO|STREAM.ICM France
AbbottConfirmRx
BiotronikDDD-CLS
ZollShort Term Wearable Defibrillator
Rhythm PharmaceuticalsInsertable Cardiac Monitor Implant

Clinical Trials (7)

Total enrollment: 1,082 patients across 7 trials

NCT00359203Rhythm PharmaceuticalsDual chamber pacemeker

ISSUE3: International Study on Syncope of Uncertain Etiology 3

Start: Sep 2006Est. completion: Nov 2012511 patients
Phase 4Completed
NCT00170261Rhythm PharmaceuticalsUse of an Implantable Loop Recorder

ELIAS: Early Loop-Recorder in Suspected Arrhythmogenic Syncope

Start: Apr 2002Est. completion: Sep 2006100 patients
Phase 4Completed
NCT04206774BiotronikBIO|STREAM.ICM France

BIO|STREAM.ICM France

Start: Mar 2020Est. completion: Dec 202192 patients
N/ACompleted
NCT03803969AbbottConfirmRx

ConfirmRxTM: Posture and Activity

Start: Oct 2018Est. completion: Jul 2020100 patients
N/ACompleted
NCT02324920BiotronikDDD-CLS

Benefit of Dual-chamber Pacing With Closed Loop Stimulation (CLS) in Tilt-induced Cardioinhibitory Reflex Syncope

Start: Oct 2015Est. completion: Jul 2020128 patients
N/ACompleted
NCT02188147ZollShort Term Wearable Defibrillator

Ambulatory Post-Syncope Arrhythmia Protection Feasibility Study

Start: Aug 2014Est. completion: Apr 2020
N/ACompleted
NCT01965899Rhythm PharmaceuticalsInsertable Cardiac Monitor Implant

Usability Study to Assess the Reveal LINQ Insertable Cardiac Monitor System

Start: Sep 2013Est. completion: Sep 2015151 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

4 companies competing in this space