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Syncope

2
Pipeline Programs
8
Companies
10
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
0
2
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

7 companies ranked by most advanced pipeline stage

Medtronic
MedtronicNJ - Phillipsburg
4 programs
2
Dual chamber pacemekerPhase 41 trial
Use of an Implantable Loop RecorderPhase 41 trial
Insertable Cardiac Monitor ImplantN/A1 trial
International Study on Syncope of Uncertain EtiologyN/A1 trial
Active Trials
NCT01965899Completed151Est. Sep 2015
NCT00120094Terminated400Est. Jun 2005
NCT00359203Completed511Est. Nov 2012
+1 more trials
Rhythm Pharmaceuticals
3 programs
Insertable Cardiac Monitor ImplantN/A
Dual chamber pacemekerPHASE_4
Use of an Implantable Loop RecorderPHASE_4
Biotronik
BiotronikGermany - Berlin
2 programs
BIO|STREAM.ICM FranceN/A1 trial
DDD-CLSN/A1 trial
Active Trials
NCT04206774Completed92Est. Dec 2021
NCT02324920Completed128Est. Jul 2020
Abbott
AbbottABBOTT PARK, IL
1 program
ConfirmRxN/A1 trial
Active Trials
NCT03803969Completed100Est. Jul 2020
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
1 program
Emergency Department Observation ProtocolN/A1 trial
Active Trials
NCT01003262Completed123Est. Dec 2011
Zoll
ZollCA - San Jose
1 program
Short Term Wearable DefibrillatorN/A1 trial
Active Trials
NCT02188147Completed39Est. Apr 2020
iRhythm Technologies
1 program
Zio monitorN/A1 trial
Active Trials
NCT07118124Active Not Recruiting36Est. Mar 2026

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
MedtronicDual chamber pacemeker
MedtronicUse of an Implantable Loop Recorder
iRhythm TechnologiesZio monitor
BiotronikBIO|STREAM.ICM France
AbbottConfirmRx
BiotronikDDD-CLS
ZollShort Term Wearable Defibrillator
MedtronicInsertable Cardiac Monitor Implant
Angeles TherapeuticsEmergency Department Observation Protocol
MedtronicInternational Study on Syncope of Uncertain Etiology

Clinical Trials (10)

Total enrollment: 1,680 patients across 10 trials

NCT00359203MedtronicDual chamber pacemeker

ISSUE3: International Study on Syncope of Uncertain Etiology 3

Start: Sep 2006Est. completion: Nov 2012511 patients
Phase 4Completed
NCT00170261MedtronicUse of an Implantable Loop Recorder

ELIAS: Early Loop-Recorder in Suspected Arrhythmogenic Syncope

Start: Apr 2002Est. completion: Sep 2006100 patients
Phase 4Completed
NCT07118124iRhythm TechnologiesZio monitor

Pediatric Adhesion and New Dermal Approach Study

Start: Aug 2025Est. completion: Mar 202636 patients
N/AActive Not Recruiting
NCT04206774BiotronikBIO|STREAM.ICM France

BIO|STREAM.ICM France

Start: Mar 2020Est. completion: Dec 202192 patients
N/ACompleted
NCT03803969AbbottConfirmRx

ConfirmRxTM: Posture and Activity

Start: Oct 2018Est. completion: Jul 2020100 patients
N/ACompleted
NCT02324920BiotronikDDD-CLS

Benefit of Dual-chamber Pacing With Closed Loop Stimulation (CLS) in Tilt-induced Cardioinhibitory Reflex Syncope

Start: Oct 2015Est. completion: Jul 2020128 patients
N/ACompleted
NCT02188147ZollShort Term Wearable Defibrillator

Ambulatory Post-Syncope Arrhythmia Protection Feasibility Study

Start: Aug 2014Est. completion: Apr 202039 patients
N/ACompleted
NCT01965899MedtronicInsertable Cardiac Monitor Implant

Usability Study to Assess the Reveal LINQ Insertable Cardiac Monitor System

Start: Sep 2013Est. completion: Sep 2015151 patients
N/ACompleted
NCT01003262Angeles TherapeuticsEmergency Department Observation Protocol

Evaluating an Emergency Department Observation Syncope Protocol for Older Adults

Start: Mar 2010Est. completion: Dec 2011123 patients
N/ACompleted
NCT00120094MedtronicInternational Study on Syncope of Uncertain Etiology

International Study on Syncope of Uncertain Etiology

Start: Jun 2002Est. completion: Jun 2005400 patients
N/ATerminated

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

8 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.