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Stress Disorders, Post-Traumatic

4
Pipeline Programs
11
Companies
10
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
2
1
1
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
2100%
+ 10 programs with unclassified modality

Competitive Landscape

9 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
1 program
1
ZoloftPhase 31 trial
Active Trials
NCT00150306Terminated160Est. Jul 2007
ViiV Healthcare
ViiV HealthcareNC - Durham
1 program
1
Cognitive-behavioral therapy and paroxetine-CRPhase 2/3
Lundbeck
LundbeckDenmark - Copenhagen
1 program
1
BrexpiprazolePhase 2Small Molecule
Otsuka
OtsukaJapan - Tokushima
1 program
1
BrexpiprazolePhase 2Small Molecule1 trial
Active Trials
NCT03033069Completed336Est. Nov 2018
Sound Pharmaceuticals
3 programs
Telephone Case MonitoringN/A1 trial
prazosinN/A1 trial
prazosin hydrochlorideN/A1 trial
Active Trials
NCT02655991Completed358Est. Aug 2014
NCT00202449Terminated59Est. Feb 2008
NCT00990106Completed67Est. Mar 2013
Human BioSciences
Human BioSciencesWV - Martinsburg
2 programs
Forest walkN/A1 trial
PTSD Service DogN/A1 trial
Active Trials
NCT04116489Completed19Est. Dec 2022
NCT05900479Active Not Recruiting150Est. Aug 2028
Apollo Therapeutics
Apollo TherapeuticsUK - Cambridge
1 program
Apollo WearableN/A1 trial
Active Trials
NCT05274230Unknown200Est. Dec 2025
Defence Therapeutics
Defence TherapeuticsBC - Vancouver
1 program
Repetitive Transcranial Magnetic Stimulation to Right Dorsolateral Prefrontal CortexN/A1 trial
Active Trials
NCT03840369Completed25Est. Mar 2022
GSK
GSKLONDON, United Kingdom
1 program
Cognitive-behavioral therapy and paroxetine-CRPHASE_2_31 trial
Active Trials
NCT00215163Completed17Est. Jun 2006

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
PfizerZoloft
GSKCognitive-behavioral therapy and paroxetine-CR
OtsukaBrexpiprazole
Human BioSciencesPTSD Service Dog
Apollo TherapeuticsApollo Wearable
Defence TherapeuticsRepetitive Transcranial Magnetic Stimulation to Right Dorsolateral Prefrontal Cortex
Human BioSciencesForest walk
Sound Pharmaceuticalsprazosin hydrochloride
Sound PharmaceuticalsTelephone Case Monitoring
Sound Pharmaceuticalsprazosin

Clinical Trials (10)

Total enrollment: 1,391 patients across 10 trials

NCT00150306PfizerZoloft

A Ten-Week Study Evaluating The Effectiveness And Safety Of Zoloft In Children And Adolescents With A Diagnosis Of PTSD

Start: Nov 2002Est. completion: Jul 2007160 patients
Phase 3Terminated
NCT00215163GSKCognitive-behavioral therapy and paroxetine-CR

Paroxetine-CR to Treat Post-Traumatic Stress Disorder (PTSD) Symptomatic After Initial Exposure Therapy

Start: Dec 2002Est. completion: Jun 200617 patients
Phase 2/3Completed
NCT03033069OtsukaBrexpiprazole

A Study of Flexible Dose Brexpiprazole as Monotherapy or Combination Therapy in the Treatment of Adults With Post-traumatic Stress Disorder (PTSD)

Start: Jan 2017Est. completion: Nov 2018336 patients
Phase 2Completed
NCT05900479Human BioSciencesPTSD Service Dog

Multi-site, Longitudinal Trial Evaluating the Efficacy, Mechanisms, and Moderators of Service Dogs for Military Veterans With PTSD

Start: Sep 2023Est. completion: Aug 2028150 patients
N/AActive Not Recruiting
NCT05274230Apollo TherapeuticsApollo Wearable

Sustaining Remission From PTSD Using Tuned Vibroacoustic Stimulation (TVS) Following MDMA-Assisted Psychotherapy

Start: Dec 2021Est. completion: Dec 2025200 patients
N/AUnknown
NCT03840369Defence TherapeuticsRepetitive Transcranial Magnetic Stimulation to Right Dorsolateral Prefrontal Cortex

Pathophysiological Understanding and Treatment of PTSD: an rTMS Approach

Start: Jun 2020Est. completion: Mar 202225 patients
N/ACompleted
NCT04116489Human BioSciencesForest walk

Wildlife and Wellbeing: An Animal-Assisted Intervention for Veterans With PTSD

Start: Jul 2019Est. completion: Dec 202219 patients
N/ACompleted
NCT00990106Sound Pharmaceuticalsprazosin hydrochloride

Augmentation Trial of Prazosin for Post-Traumatic Stress Disorder (PTSD)

Start: Sep 2009Est. completion: Mar 201367 patients
N/ACompleted
NCT02655991Sound PharmaceuticalsTelephone Case Monitoring

Homecoming Line: Telephone Support for Veterans

Start: Mar 2008Est. completion: Aug 2014358 patients
N/ACompleted
NCT00202449Sound Pharmaceuticalsprazosin

Prazosin vs Paroxetine in Combat Stress-Related Post-Traumatic Stress Disorder (PTSD) Nightmares & Sleep Disturbance

Start: Jul 2004Est. completion: Feb 200859 patients
N/ATerminated

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
11 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.