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Spinal Cord Injury

31
Pipeline Programs
30
Companies
50
Clinical Trials
7 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
9
7
7
4
1
3
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 68 programs with unclassified modality

Competitive Landscape

41 companies ranked by most advanced pipeline stage

Moleac
MoleacSingapore - Singapore
1 program
1
NeuroAiDPhase 41 trial
Active Trials
NCT02537899Completed30Est. Sep 2023
AbbVie
AbbVieNORTH CHICAGO, IL
1 program
1
botulinum toxin APhase 41 trial
Active Trials
NCT00320281Completed19Est. Aug 2008
Pfizer
PfizerNEW YORK, NY
1 program
1
sildenafilPhase 41 trial
Active Trials
NCT00654082Completed88Est. Aug 2003
Human BioSciences
Human BioSciencesWV - Martinsburg
9 programs
2
1
1
1
1
Zoledronic acidPhase 31 trial
Locomotor trainingPhase 2/31 trial
body weight-supported treadmill trainingPhase 21 trial
Paired Associative StimulationPhase 1/21 trial
Body weight support treadmill trainingPhase 11 trial
+4 more programs
Active Trials
NCT07062575Suspended10Est. Jun 2026
NCT07036107Recruiting80Est. Sep 2027
NCT01012635Completed36Est. Dec 2011
+6 more trials
Spine BioPharma
4 programs
1
1
1
RiluzolePhase 2/3Small Molecule1 trial
Autologous bone marrow mononuclear cell transplantationPhase 21 trial
Autologous bone marrow mononuclear cell transplantationPhase 11 trial
The International Spinal Cord Injury Blood Biomarker Longitudinal Evaluation (I-SCRIBBLE) StudyN/A1 trial
Active Trials
NCT06839300Recruiting260Est. Dec 2029
NCT02027246Withdrawn0Est. Feb 2013
NCT02009124Withdrawn0Est. Dec 2018
+1 more trials
Temple Therapeutics
Temple TherapeuticsNetherlands - Geleen
2 programs
1
Cycling with functional electrical stimulationPhase 2/31 trial
Association Between Types of Pain and Motor Activities Physical ActivityN/A1 trial
Active Trials
NCT05236933Completed17Est. Feb 2023
NCT01244594Completed17Est. Oct 2013
BioAxone Biosciences
1
CethrinPhase 2/31 trial
Active Trials
NCT02053883Withdrawn0
Biocorp
4 programs
2
1
1
Allogeneic Human Induced Pluripotent Stem CellPhase 21 trial
Autologous Adipose Tissue derived MSCs TransplantationPhase 1/21 trial
Allogeneic Human Induced Pluripotent Stem CellPhase 11 trial
Autologous Adipose Derived Mesenchymal Stem CellsPhase 11 trial
Active Trials
NCT06976229Recruiting12Est. May 2028
NCT01274975Completed8Est. Feb 2010
NCT01769872Completed15
+1 more trials
XellSmart
XellSmartChina - Shanghai
2 programs
1
1
Allogeneic Human Induced Pluripotent Stem CellPhase 2
Allogeneic Human Induced Pluripotent Stem CellPhase 1
Tanabe Pharma America
Tanabe Pharma AmericaNJ - Jersey City
2 programs
1
1
MT-3921Phase 21 trial
MT-3921 Low dosePhase 11 trial
Active Trials
NCT04096950Completed3Est. Jan 2021
NCT04683848Completed72Est. Apr 2025
Innova Therapeutics
Innova TherapeuticsSC - Mt. Pleasant
1 program
1
Autologous Mesenchymal Stem CellsPhase 21 trial
Active Trials
NCT01694927Unknown30Est. Jun 2014
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
1
Testosterone EnanthatePhase 21 trial
Active Trials
NCT04460872Recruiting21Est. Jun 2026
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
4 programs
1
AMES TreatmentPhase 1/21 trial
AMES TherapyN/A1 trial
AMES treatmentN/A1 trial
Augmented Blood PressureN/A1 trial
Active Trials
NCT01974635Terminated2Est. Apr 2015
NCT00833105Completed13Est. Jan 2012
NCT02878850Completed94Est. Jul 2023
+1 more trials
R-Bio
2 programs
1
1
Autologous Adipose Tissue derived MSCs TransplantationPhase 1/2
Autologous Adipose Derived Mesenchymal Stem CellsPhase 1
StemCyte
StemCyteCA - Baldwin Park
1 program
1
Conventional TreatmentPhase 1/21 trial
Active Trials
NCT01471613Completed16Est. Jan 2014
Nordic Pharma
Nordic PharmaFrance - Paris
1 program
1
SPINALONPhase 1/21 trial
Active Trials
NCT01484184Completed50Est. Aug 2015
Innovation Pharmaceuticals
1 program
1
Transplantation of bone marrow stromal cellPhase 1/21 trial
Active Trials
NCT00695149Terminated5Est. Mar 2010
NeuroTrauma Sciences
1
Probiotic Lactobacillus GR-1 and RC-14Phase 11 trial
Active Trials
NCT00594594Terminated2Est. May 2009
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
4 programs
Electromagnetic NeuromodulationN/A1 trial
Epidural StimulatorN/A1 trial
Standing and Stepping with spinal cord Epidural StimulationN/A1 trial
Transcutaneous Electrical Spinal Cord StimulationN/A1 trial
Active Trials
NCT02331979Recruiting24Est. Jan 2027
NCT02592668Completed2Est. Feb 2019
NCT02339233Completed8Est. Oct 2019
+1 more trials
Ekso Bionics
Ekso BionicsSAN RAFAEL, CA
2 programs
EksoN/A1 trial
Overground Robotic ExoskeletonN/A1 trial
Active Trials
NCT02132702Completed60Est. Jan 2017
NCT07030322Enrolling By Invitation5Est. Sep 2027
Alliance Pharmaceuticals
2 programs
Gut Dysbiosis in Spinal Cord Injury RehabilitationN/A
Molecular Determinants of Spinal Cord Injury RehabilitationN/A
GAIA BioMedicine
Gut Dysbiosis in Spinal Cord Injury RehabilitationN/A1 trial
Molecular Determinants of Spinal Cord Injury RehabilitationN/A1 trial
Active Trials
NCT06892106Completed106Est. Oct 2023
NCT07383077Completed106Est. Oct 2023
Coloplast
ColoplastAustralia - Mulgrave
2 programs
Intermittent catheter CP063CCN/A1 trial
Intermittent catheterisationPHASE_11 trial
Active Trials
NCT01142115Completed41Est. May 2010
NCT01292941Withdrawn0Est. Jun 2011
ONWARD Medical
ONWARD MedicalNetherlands - Eindhoven
1 program
ARC-IM Thoracic System implantationN/A1 trial
Active Trials
NCT05941819Unknown16Est. Sep 2025
Amarna Therapeutics
Bone Marrow Collection in Healthy Volunteers (iCell)N/A1 trial
Active Trials
NCT02118740Unknown15Est. Apr 2018
Neuroplast
NeuroplastFrance - Montpellier
1 program
Bone Marrow Collection in Healthy Volunteers (iCell)N/A
Aneuvo
1 program
ExaStim Stimulation SystemN/A1 trial
Active Trials
NCT06850363Completed33Est. Mar 2026
NeuralInk
1 program
Eye TrackerN/A1 trial
Active Trials
NCT07407725Recruiting60Est. Jun 2027
Medtronic
MedtronicNJ - Phillipsburg
1 program
Medtronic Activa PC+SN/A1 trial
Active Trials
NCT02564419Completed1Est. Nov 2019
Synapse Biomedical
Synapse BiomedicalOH - Oberlin
1 program
NeuRx DPSN/A1 trial
Active Trials
NCT00010374Completed54Est. Oct 2008

+11 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
MoleacNeuroAiD
AbbViebotulinum toxin A
Pfizersildenafil
Human BioSciencesZoledronic acid
BioAxone BiosciencesCethrin
Spine BioPharmaRiluzole
Temple TherapeuticsCycling with functional electrical stimulation
Human BioSciencesLocomotor training
BiocorpAllogeneic Human Induced Pluripotent Stem Cell
Tanabe Pharma AmericaMT-3921
Colorado TherapeuticsTestosterone Enanthate
Spine BioPharmaAutologous bone marrow mononuclear cell transplantation
Innova TherapeuticsAutologous Mesenchymal Stem Cells
SanofiHP184
Human BioSciencesbody weight-supported treadmill training

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 2,258 patients across 50 trials

Spinal Cord Injury - Assessing Tolerability and Use of Combined Rehabilitation and NeuroAiD

Start: Apr 2015Est. completion: Sep 202330 patients
Phase 4Completed
NCT00320281AbbViebotulinum toxin A

Investigating Botulinum Toxin A to Treat Acute Neck/Upper Shoulder Pain Following a New Spinal Cord Injury.

Start: Apr 2006Est. completion: Aug 200819 patients
Phase 4Completed

A Study Evaluating the Efficacy and Safety of Sildenafil in Men With Traumatic Spinal Cord Injury and Erectile Dysfunction

Start: Sep 2002Est. completion: Aug 200388 patients
Phase 4Completed

Zoledronic Acid in Acute Spinal Cord Injury

Start: Sep 2012Est. completion: Mar 201816 patients
Phase 3Completed

Cethrin in Acute Cervical Spinal Cord Injury

Start: Jul 20150
Phase 2/3Withdrawn

Riluzole in Spinal Cord Injury Study

Start: Oct 2013Est. completion: Oct 2020193 patients
Phase 2/3Terminated
NCT01244594Temple TherapeuticsCycling with functional electrical stimulation

The Effects of Two Functional Electrical Stimulation Cycling Paradigms

Start: Jul 2010Est. completion: Oct 201317 patients
Phase 2/3Completed

Comparison of Post-pinal Cord Injury (SCI) Locomotor Training Techniques

Start: Nov 2003Est. completion: Nov 200874 patients
Phase 2/3Completed
NCT06974968BiocorpAllogeneic Human Induced Pluripotent Stem Cell

Efficacy of iPSC-Derived Motor Neuron Cells (XS228) in Subacute Spinal Cord Injury: A Phase II Randomized Controlled Trial

Start: May 2028Est. completion: May 203160 patients
Phase 2Not Yet Recruiting

Study to Assess the Efficacy and Safety of MT-3921 in Subjects With Acute Traumatic Cervical Spinal Cord Injury

Start: Aug 2021Est. completion: Apr 202572 patients
Phase 2Completed
NCT04460872Colorado TherapeuticsTestosterone Enanthate

Locomotor Training With Testosterone to Promote Bone and Muscle Health After Spinal Cord Injury

Start: Jan 2021Est. completion: Jun 202621 patients
Phase 2Recruiting
NCT02009124Spine BioPharmaAutologous bone marrow mononuclear cell transplantation

Stem Cell Therapy in Spinal Cord Injury

Start: Aug 2012Est. completion: Dec 20180
Phase 2Withdrawn
NCT01694927Innova TherapeuticsAutologous Mesenchymal Stem Cells

Autologous Mesenchymal Stem Cells in Spinal Cord Injury (SCI) Patients

Start: Jan 2012Est. completion: Jun 201430 patients
Phase 2Unknown

HP184 in Chronic Spinal Cord Injury Subjects

Start: Oct 2004Est. completion: Dec 2005262 patients
Phase 2Completed
NCT00006429Human BioSciencesbody weight-supported treadmill training

Treadmill Training for Spinal Cord Injury

Start: Mar 1999Est. completion: Feb 2004200 patients
Phase 2Completed
NCT07223710Human BioSciencesPaired Associative Stimulation

Improving Walking After Spinal Cord Injury

Start: Nov 2025Est. completion: Jul 202620 patients
Phase 1/2Not Yet Recruiting
NCT02490501BioArcticSC0806 and rehabilitation

Safety and Efficacy of SC0806 (Fibroblast Growth Factor 1 and a Device) in Traumatic Spinal Cord Injury Subjects

Start: Jun 2015Est. completion: May 202510 patients
Phase 1/2Completed

Study to Assess Safety, Tolerability and MTD of a Central Pattern Generator-activating Tritherapy (SPINALON) in Patients With Chronic Spinal Cord Injury

Start: Jul 2013Est. completion: Aug 201550 patients
Phase 1/2Completed
NCT01769872BiocorpAutologous Adipose Tissue derived MSCs Transplantation

Safety and Effect of Adipose Tissue Derived Mesenchymal Stem Cell Implantation in Patients With Spinal Cord Injury

Start: Jan 201315 patients
Phase 1/2Completed

Spinal Cord Injury Leg Rehabilitation

Start: Nov 2011Est. completion: Nov 20162 patients
Phase 1/2Terminated
NCT01471613StemCyteConventional Treatment

Lithium, Cord Blood Cells and the Combination in the Treatment of Acute & Sub-acute Spinal Cord Injury

Start: Sep 2011Est. completion: Jan 201416 patients
Phase 1/2Completed
NCT00695149Innovation PharmaceuticalsTransplantation of bone marrow stromal cell

Treatment for Acute Spinal Cord Injury

Start: Jul 2005Est. completion: Mar 20105 patients
Phase 1/2Terminated

A Safety Study for Cethrin (BA-210) in the Treatment of Acute Thoracic and Cervical Spinal Cord Injuries

Start: Feb 2005Est. completion: Feb 200948 patients
Phase 1/2Completed
NCT06976229BiocorpAllogeneic Human Induced Pluripotent Stem Cell

Safety and Early Efficacy of iPSC-Derived Motor Neuron Progenitor Cells (XS228) in Subacute Spinal Cord Injury: A Phase I Trial

Start: Jul 2025Est. completion: May 202812 patients
Phase 1Recruiting
NCT06989905Human BioSciencesUp-conditioning of the wrist extensor motor evoked potential

MEP Up-conditioning to Target Corticospinal Plasticity

Start: May 2025Est. completion: Mar 202711 patients
Phase 1Recruiting

A Phase I Safety Study of NVG-291 in Healthy Adults

Start: May 2021Est. completion: Jul 202374 patients
Phase 1Completed

Safety and Pharmacokinetics Study of MT-3921 in Spinal Cord Injury

Start: Apr 2020Est. completion: Jan 20213 patients
Phase 1Completed
NCT01328860Knight Therapeuticsbone marrow progenitor cells

Autologous Stem Cells for Spinal Cord Injury (SCI) in Children

Start: Apr 2011Est. completion: Jun 201610 patients
Phase 1Terminated
NCT01292941ColoplastIntermittent catheterisation

Clinical Study Evaluating Safety of a New Catheter for Urinary Intermittent Catheter in Healthy Volunteers

Start: Mar 2011Est. completion: Jun 20110
Phase 1Withdrawn

Safety Study of GRNOPC1 in Spinal Cord Injury

Start: Oct 2010Est. completion: Jul 20135 patients
Phase 1Completed
NCT01274975BiocorpAutologous Adipose Derived Mesenchymal Stem Cells

Autologous Adipose Derived MSCs Transplantation in Patient With Spinal Cord Injury.

Start: Jul 2009Est. completion: Feb 20108 patients
Phase 1Completed
NCT02027246Spine BioPharmaAutologous bone marrow mononuclear cell transplantation

Safety and Efficacy of Stem Cell Therapy in Spinal Cord Injury

Start: Dec 2008Est. completion: Feb 20130
Phase 1Withdrawn
NCT00594594NeuroTrauma SciencesProbiotic Lactobacillus GR-1 and RC-14

Adjuntive Probiotic Therapy in Treating Urinary Tract Infections in Spinal Cord Injury

Start: Sep 2007Est. completion: May 20092 patients
Phase 1Terminated
NCT00061295Human BioSciencesBody weight support treadmill training

Treadmill Training With Body Weight Support in Patients With Spinal Cord Injury

Start: Mar 1999Est. completion: Feb 2004
Phase 1Unknown
NCT06839300Spine BioPharmaThe International Spinal Cord Injury Blood Biomarker Longitudinal Evaluation (I-SCRIBBLE) Study

The International Spinal Cord Injury Blood Biomarker Longitudinal Evaluation (I-SCRIBBLE) Study

Start: Feb 2026Est. completion: Dec 2029260 patients
N/ARecruiting

A Trial on the Clinical and Socioeconomic Impact of Wearable Exoskeletons for Spinal Cord Injury Rehabilitation in the Spanish Healthcare System

Start: Jan 2026Est. completion: Sep 202780 patients
N/ARecruiting

Clinical Outcome Assessment for AT & BCI

Start: Jan 2026Est. completion: Jun 202760 patients
N/ARecruiting
NCT07030322Ekso BionicsOverground Robotic Exoskeleton

Health and Financial Impact on the Use of a Personal Exoskeleton in the Home and Community: a Case Study

Start: Aug 2025Est. completion: Sep 20275 patients
N/AEnrolling By Invitation

Exoskeleton Training at Home to Assist Participants With Spinal Cord Injuries to Perform Ambulatory Functions.

Start: Jun 2025Est. completion: Jun 202610 patients
N/ASuspended
NCT06850363AneuvoExaStim Stimulation System

ExaStim Upper Limb Home Use Clinical Validation Study

Start: Mar 2025Est. completion: Mar 202633 patients
N/ACompleted
NCT05941819ONWARD MedicalARC-IM Thoracic System implantation

ARC Therapy to Restore Hemodynamic Stability and Trunk Control in People With Spinal Cord Injury

Start: Sep 2023Est. completion: Sep 202516 patients
N/AUnknown
NCT05236933Temple TherapeuticsAssociation Between Types of Pain and Motor Activities Physical Activity

Association Between Types of Pain and Motor Activities Physical Activity

Start: Mar 2022Est. completion: Feb 202317 patients
N/ACompleted
NCT07383077GAIA BioMedicineMolecular Determinants of Spinal Cord Injury Rehabilitation

Molecular Determinants of Spinal Cord Injury Rehabilitation

Start: May 2021Est. completion: Oct 2023106 patients
N/ACompleted
NCT06892106GAIA BioMedicineGut Dysbiosis in Spinal Cord Injury Rehabilitation

Gut Dysbiosis in Spinal Cord Injury Rehabilitation

Start: May 2021Est. completion: Oct 2023106 patients
N/ACompleted
NCT02878850Oregon TherapeuticsAugmented Blood Pressure

Randomized Trial of Early Hemodynamic Management of Patients Following Acute Spinal Cord Injury

Start: May 2017Est. completion: Jul 202394 patients
N/ACompleted

Spinal Cord Injury Epidural Stimulation

Start: Jan 2016Est. completion: Feb 20192 patients
N/ACompleted
NCT02800915Integrated BiosciencesService innovation with focus on multidisciplinary collaboration

Telemedicine Makes the Patient Stay in Hospital at Home

Start: Jan 2016Est. completion: Aug 201956 patients
N/ACompleted
NCT02564419MedtronicMedtronic Activa PC+S

Brain Machine Interface (BMI) in Subjects Living With Quadriplegia

Start: Nov 2015Est. completion: Nov 20191 patients
N/ACompleted
NCT02331979Angeles TherapeuticsElectromagnetic Neuromodulation

Improving Bladder Function in SCI by Neuromodulation

Start: Sep 2015Est. completion: Jan 202724 patients
N/ARecruiting
NCT02118740Amarna TherapeuticsBone Marrow Collection in Healthy Volunteers (iCell)

Bone Marrow Collection in Healthy Volunteers (iCell)

Start: Jun 2015Est. completion: Apr 201815 patients
N/AUnknown

Related Jobs

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
7 actively recruiting trials targeting 2,258 patients
30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.