Spinal Cord Injuries

Pipeline Programs

Companies

Clinical Trials

12 recruiting

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

31 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

Human BioSciences

25 programs

AmitriptylinePhase 41 trial

Lifestyle RedesignPhase 31 trial

Locomotor treadmill training with body weight supportPhase 2/31 trial

Body weight supported locomotor trainingPhase 21 trial

Testosterone UndecanoatePhase 21 trial

+20 more programs

Active Trials

NCT05643313Completed10Est. Aug 2023

NCT04876794Completed24Est. Nov 2021

NCT05590065Completed5Est. Jan 2023

+21 more trials

Eusol BiotechTaiwan - Taipei

1 program

ES135Phase 31 trial

Active Trials

NCT03229031Suspended160Est. Dec 2026

Innovation PharmaceuticalsMA - Wakefield

2 programs

Transplantation of autologous bone marrow-derived mononuclear cells by lumbar injectionPhase 21 trial

Alternating air wheelchair cushionN/A1 trial

Active Trials

NCT03430375Completed29Est. Aug 2021

NCT02923817Unknown30Est. Jun 2019

Temple TherapeuticsNetherlands - Geleen

2 programs

WI programPhase 2

Passive feedback and JITAIN/A1 trial

Active Trials

NCT03773692Completed20Est. Nov 2018

StemCyteCA - Baldwin Park

1 program

Umbilical Cord Blood Mononuclear CellPhase 21 trial

Active Trials

NCT03979742Terminated6Est. Dec 2024

Kringle PharmaJapan - Ibaraki

1 program

KP-100ITPhase 1/21 trial

Active Trials

NCT02193334Completed45Est. Jul 2018

EicOsisCA - Davis

1 program

EC5026 oral tabletPhase 1

Coloplast

5 programs

CystometrogramN/A1 trial

HPC - SpeediCath ®N/A1 trial

SelfCathN/A1 trial

SpeediCathN/A1 trial

test intermittent catheterN/A1 trial

Active Trials

NCT05207826Withdrawn0Est. Dec 2023

NCT05003999Completed20Est. Jun 2019

NCT02230540Terminated8Est. Sep 2014

+2 more trials

Colorado TherapeuticsCO - Louisville

4 programs

Brachial intra-arterial infusion of vasoactive and antioxidant drugsN/A1 trial

Intra-arterial Infusion of Vasoactive AgentsN/A1 trial

implanted epidural stimulatorN/A1 trial

Active Trials

NCT06443151Recruiting60Est. Mar 2027

NCT07227727Recruiting40Est. Jul 2027

NCT07227740Recruiting48Est. Jul 2028

+1 more trials

Angeles Therapeutics

3 programs

Acute Intermittent Hypoxia + Non Invasive Spinal Cord Stimulation + Gait TrainingN/A1 trial

Epidural stimulationN/A1 trial

trans-spinal Electrical StimulationN/A1 trial

Active Trials

NCT03922802Completed14Est. Jan 2023

NCT04883463Recruiting12Est. Dec 2028

NCT04171375Completed2Est. Nov 2021

LakeShore BiopharmaDAXING DISTRICT, BEIJING, China

3 programs

MENTOR + TelehealthN/A1 trial

Movement-2-Music + Social Networking SupportN/A1 trial

eM2MN/A1 trial

Active Trials

NCT03207737Completed23Est. Apr 2020

NCT04726891Completed36Est. Oct 2023

NCT03797378Completed108Est. Sep 2025

Cosmo PharmaceuticalsIreland - Dublin

2 programs

ExoAtlet IIN/A1 trial

Gait training using ExoAtlet exoskeletonN/A1 trial

Active Trials

NCT04532723Withdrawn0Est. Oct 2023

NCT04215081Completed20Est. Jan 2020

ConvaTecNJ - Bridgewater

2 programs

GentleCath™ Air catheterN/A1 trial

Self-catheterizationN/A1 trial

Active Trials

NCT04847609Withdrawn0Est. Oct 2021

NCT05380661Completed22Est. Apr 2026

NeuroplastFrance - Montpellier

2 programs

Neuro-CellsPHASE_11 trial

Neuro-CellsPHASE_2_31 trial

Active Trials

NCT04205019Completed10Est. Mar 2023

NCT03935724Unknown16Est. Aug 2024

Heidelberg PharmaGermany - Ladenburg

1 program

ABLE ExoskeletonN/A

LabcorpBURLINGTON, NC

1 program

ABLE ExoskeletonN/A

ONWARD MedicalNetherlands - Eindhoven

1 program

ARC-IM System ImplantationN/A1 trial

Active Trials

NCT07147296Recruiting60Est. Mar 2029

BiosensicsMA - Newton

1 program

An interactive telehealth monitoring and biofeedback systemN/A1 trial

Active Trials

NCT04266808Unknown50Est. Jan 2022

Spine BioPharmaNY - New York

1 program

Brain-Computer Interface control of robotic arms.N/A1 trial

Active Trials

NCT02443558Completed20Est. Dec 2018

Petros PharmaceuticalsNEW YORK, NY

1 program

Cold environment participants with spinal cord injuryN/A1 trial

Active Trials

NCT04215939Completed16Est. Jul 2020

Ekso BionicsSAN RAFAEL, CA

1 program

EksoN/A1 trial

Active Trials

NCT02566850Terminated4Est. Jul 2017

Stoke TherapeuticsBEDFORD, MA

1 program

Experimental: Device InterventionN/A1 trial

Active Trials

NCT05615766Recruiting9Est. Mar 2026

ComphyaSwitzerland - Lausanne

1 program

Implantation of the caverStim deviceN/A1 trial

Active Trials

NCT06347575Withdrawn0Est. Nov 2025

City TherapeuticsMA - Cambridge

1 program

Keeping a 1-day food consumption record by the patientN/A1 trial

Active Trials

NCT05997251CompletedEst. Mar 2022

PfizerNEW YORK, NY

1 program

PregabalinN/A1 trial

Active Trials

NCT00978341Terminated15Est. Oct 2008

SpineXCA - Northridge

1 program

Spinal COrd NEuromodulationN/A1 trial

Active Trials

NCT06838637Recruiting6Est. Apr 2026

Providence TherapeuticsAB - Calgary

1 program

Transcutaneous Spinal Cord StimulationN/A1 trial

Active Trials

NCT04604951Unknown40Est. Aug 2024

LundbeckDenmark - Copenhagen

1 program

Xiao procedureN/A1 trial

Active Trials

NCT01274312Completed10Est. Sep 2013

PathMaker NeurosystemsMA - Boston

1 program

tsDCS+pDCSN/A1 trial

Active Trials

NCT07467850Completed8Est. Sep 2024

Boehringer IngelheimINGELHEIM, Germany

1 program

KUC 7483 CLPHASE_11 trial

Active Trials

NCT02259751Completed26

+1 more companies

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

2027

2028

2029

Human BioSciencesAmitriptyline

Eusol BiotechES135

Human BioSciencesLifestyle Redesign

NeuroplastNeuro-Cells

Human BioSciencesLocomotor treadmill training with body weight support

Human BioSciencesWI program

StemCyteUmbilical Cord Blood Mononuclear Cell

Human BioSciencesTestosterone Undecanoate

Innovation PharmaceuticalsTransplantation of autologous bone marrow-derived mononuclear cells by lumbar injection

Human BioSciencesBody weight supported locomotor training

NervGen PharmaNVG-291

Human BioSciencesCaffeine

Kringle PharmaKP-100IT

Human BioSciencesEC5026 oral tablet

NeuroplastNeuro-Cells

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 1,880 patients across 50 trials

NCT00006428 Human BioSciencesAmitriptyline

Chronic Pain in Spinal Cord Injury

Start: Aug 1996Est. completion: May 2007100 patients

Phase 4Completed

NCT03229031 Eusol BiotechES135

A Multicenter, Randomized, Double-blind, Placebo-controlled Phase 3 Study to Evaluate the Safety and Efficacy of ES135 in Subjects With Spinal Cord Injury

Start: Mar 2018Est. completion: Dec 2026160 patients

Phase 3Suspended

NCT01999816 Human BioSciencesLifestyle Redesign

Pressure Ulcer Prevention Study in SCI

Start: Sep 2008Est. completion: Sep 2015170 patients

Phase 3Completed

NCT03935724 NeuroplastNeuro-Cells

Stem Cells in Spinal Cord Injury

Start: Jan 2022Est. completion: Aug 202416 patients

Phase 2/3Unknown

NCT00059553 Human BioSciencesLocomotor treadmill training with body weight support

Retraining Walking After Spinal Cord Injury

Start: May 2000Est. completion: Jan 200516 patients

Phase 2/3Unknown

NCT05317832 Human BioSciencesWI program

Using Smartphones to Improve Physical Activity Levels of Individuals With Spinal Cord Injury

Start: May 2023Est. completion: Dec 2026196 patients

Phase 2Recruiting

NCT03979742 StemCyteUmbilical Cord Blood Mononuclear Cell

Umbilical Cord Blood Cell (MC001) Transplant Into Injured Spinal Cord Followed by the Locomotor Training

Start: Feb 2022Est. completion: Dec 20246 patients

Phase 2Terminated

NCT03576001 Human BioSciencesTestosterone Undecanoate

Multimodality Intervention for Function and Metabolism in SCI

Start: Aug 2019Est. completion: Mar 202584 patients

Phase 2Completed

NCT02923817 Innovation PharmaceuticalsTransplantation of autologous bone marrow-derived mononuclear cells by lumbar injection

Clinical Trial Using Bone Marrow-derived Mononuclear Cells for Spinal Cord Injury

Start: Sep 2016Est. completion: Jun 201930 patients

Phase 2Unknown

NCT00060983 Human BioSciencesBody weight supported locomotor training

Improving Gait in Patients With Spinal Cord Injuries

Start: May 1998Est. completion: Apr 200236 patients

Phase 2Completed

NCT05965700 NervGen PharmaNVG-291

NVG-291 in Spinal Cord Injury Subjects

Start: Aug 2023Est. completion: Apr 202640 patients

Phase 1/2Recruiting

NCT02323698 Human BioSciencesCaffeine

Effects of Caffeine and Intermittent Hypoxia on Leg Function in Human Spinal Cord Injury

Start: Jan 2019Est. completion: Feb 202236 patients

Phase 1/2Completed

NCT02193334 Kringle PharmaKP-100IT

Phase I/II Study of KP-100IT in Acute Spinal Cord Injury

Start: Jun 2014Est. completion: Jul 201845 patients

Phase 1/2Completed

NCT06438471 Human BioSciencesEC5026 oral tablet

Novel Soluble Epoxide Hydrolase Inhibitor for Neuropathic Pain in Patients With Spinal Cord Injury

Start: Feb 2026Est. completion: Jun 202736 patients

Phase 1Recruiting

NCT04205019 NeuroplastNeuro-Cells

Safety Stem Cells in Spinal Cord Injury

Start: Nov 2020Est. completion: Mar 202310 patients

Phase 1Completed

NCT02259751 Boehringer IngelheimKUC 7483 CL

Study to Determine Pharmacodynamic Effects and Pharmacokinetics of KUC 7483 CL in Patients With Spinal Cord Injury and Neurogenic Detrusor Overactivity

Start: Feb 200426 patients

Phase 1Completed

NCT07147296 ONWARD MedicalARC-IM System Implantation

ARC-IM System to Manage Symptomatic Blood Pressure Instability Secondary to Chronic Spinal Cord Injury

Start: Oct 2025Est. completion: Mar 202960 patients

N/ARecruiting

NCT05966896 Colorado Therapeuticsimplanted epidural stimulator

Epidural Stimulation to Restore Voluntary Movement Following Spinal Cord Injury

Start: Aug 2025Est. completion: Aug 20262 patients

N/ANot Yet Recruiting

NCT07227727 Colorado TherapeuticsIntra-arterial Infusion of Vasoactive Agents

Endothelial Dysfunction After SCI

Start: Jul 2025Est. completion: Jul 202740 patients

N/ARecruiting

NCT07227740 Colorado TherapeuticsIntra-arterial Infusion of Vasoactive Agents

Testosterone Deficiency and Endothelial Dysfunction After Spinal Cord Injury

Start: Jul 2025Est. completion: Jul 202848 patients

N/ARecruiting

NCT06443151 Colorado TherapeuticsBrachial intra-arterial infusion of vasoactive and antioxidant drugs

Role of Endothelial Function in SCI CVD Risk

Start: Sep 2024Est. completion: Mar 202760 patients

N/ARecruiting

NCT06347575 ComphyaImplantation of the caverStim device

Safety and Tolerability of a Novel Implantable Neurostimulator for Ameliorate Erectile Function on Spinal Cord Injured Patients

Start: May 2024Est. completion: Nov 20250

N/AWithdrawn

NCT06214208 Human BioSciencesTranscutaneous Spinal Stimulation

Influence of Spinal Stimulation Frequency on Spasticity, Motor Control, and Pain After Spinal Cord Injury

Start: Feb 2024Est. completion: Dec 202636 patients

N/ARecruiting

NCT06838637 SpineXSpinal COrd NEuromodulation

Transcutaneous Spinal Cord Stimulation Home Study

Start: Feb 2024Est. completion: Apr 20266 patients

N/ARecruiting

NCT06306352 Human BioSciencesVibrotactile feedback

Vibrotactile Feedback in Exoskeletons

Start: Mar 2023Est. completion: Jun 20237 patients

N/ACompleted

NCT05643313 Human BioSciencesABLE Exoskeleton

Clinical Investigation on Feasibility and Usability of the ABLE Exoskeleton Device for Individuals With Spinal Cord Injury to Perform Skills for Home and Community Environments

Start: Nov 2022Est. completion: Aug 202310 patients

N/ACompleted

NCT05590065 Human BioSciencesABLE Exoskeleton

Clinical Investigation on the Impact on Safety, Feasibility and Usability of the Design Changes Performed on ABLE Exoskeleton Device With Spinal Cord Injured Patients in a Hospital Setting

Start: Oct 2022Est. completion: Jan 20235 patients

N/ACompleted

NCT05615766 Stoke TherapeuticsExperimental: Device Intervention

Assessment of a Robotic Exoskeleton for Upper Limb Rehabilitation

Start: Sep 2022Est. completion: Mar 20269 patients

N/ARecruiting

NCT05380661 ConvaTecSelf-catheterization

Heart Rate Variability and Anxiety During Urinary Bladder Catheterization

Start: Jul 2022Est. completion: Apr 202622 patients

N/ACompleted

NCT07467850 PathMaker NeurosystemstsDCS+pDCS

Dual Stimulation for Spinal Cord Injury

Start: Jul 2022Est. completion: Sep 20248 patients

N/ACompleted

NCT04726891 LakeShore BiopharmaMovement-2-Music + Social Networking Support

Feasibility of the First Known Adaptive Intervention for People With SCI

Start: Jun 2022Est. completion: Oct 202336 patients

N/ACompleted

NCT04604951 Providence TherapeuticsTranscutaneous Spinal Cord Stimulation

Below the Belt: Non-invasive Neuromodulation to Treat Bladder, Bowel, and Sexual Dysfunction Following Spinal Cord Injury

Start: May 2022Est. completion: Aug 202440 patients

N/AUnknown

NCT05207826 ColoplastCystometrogram

Detrusor Activity Recovery in Acute Traumatic Spinal Cord Injuries

Start: Mar 2022Est. completion: Dec 20230

N/AWithdrawn

NCT04883463 Angeles TherapeuticsEpidural stimulation

Neuromodulation to Improve Respiratory Function in Cervical Spinal Cord Injury

Start: Sep 2021Est. completion: Dec 202812 patients

N/ARecruiting

NCT04238013 Human BioSciencesWhole Body Vibration

Neuromodulation of Ankle Muscles in Persons With SCI

Start: Jul 2021Est. completion: Jul 20211 patients

N/ATerminated

NCT03495986 Human BioSciencesFunctional Electrical Stimulation Leg Cycle Ergometry

Spinal Cord Injury Exercise and Nutrition Conceptual Engagement

Start: Jun 2021Est. completion: Jul 202426 patients

N/ACompleted

NCT04532723 Cosmo PharmaceuticalsExoAtlet II

Exoskeleton-Assisted Walking ExoAtlet II

Start: Jun 2021Est. completion: Oct 20230

N/AWithdrawn

NCT04847609 ConvaTecGentleCath™ Air catheter

GentleCath Air (Urinary Self-catheterization) - Pain in Female Patients With Neurological Vesico-sphincter Disorders

Start: May 2021Est. completion: Oct 20210

N/AWithdrawn

NCT05997251 City TherapeuticsKeeping a 1-day food consumption record by the patient

The Relationship of DASH and Mediterranean Diet Score With Serum Adiponectin Levels in Patients With Spinal Cord Injury

Start: Mar 2021Est. completion: Mar 2022

N/ACompleted

NCT04855916 Human BioSciencesABLE Exoskeleton

KAFO Orthoses Versus the ABLE Exoskeleton

Start: Feb 2021Est. completion: Sep 202110 patients

N/ACompleted

NCT03922802 Angeles TherapeuticsAcute Intermittent Hypoxia + Non Invasive Spinal Cord Stimulation + Gait Training

SCI Acute Intermittent Hypoxia and Non-Invasive Spinal Stimulation Combined With Gait Training

Start: Dec 2020Est. completion: Jan 202314 patients

N/ACompleted

NCT04876794 Human BioSciencesABLE Exoskeleton

Clinical Investigation on Safety, Feasibility and Usability of the ABLE Exoskeleton Device With Spinal Cord Injured Patients in a Hospital Setting

Start: Nov 2020Est. completion: Nov 202124 patients

N/ACompleted

NCT04266808 BiosensicsAn interactive telehealth monitoring and biofeedback system

Interactive Telehealth for Wheelchair Users

Start: Mar 2020Est. completion: Jan 202250 patients

N/AUnknown

NCT04215081 Cosmo PharmaceuticalsGait training using ExoAtlet exoskeleton

ExoAtlet II For SCI Patients

Start: Nov 2019Est. completion: Jan 202020 patients

N/ACompleted

NCT03851302 Human BioSciencesActive Remote Ischemic Conditioning

Effects of Remote Ischemic Conditioning on Hand Use in Individuals With SCI and ALS

Start: Oct 2019Est. completion: Oct 202221 patients

N/ACompleted

NCT02592291 Human BioSciencesMHealth

Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions

Start: Oct 2019Est. completion: Sep 2026160 patients

N/ARecruiting

NCT03797378 LakeShore BiopharmaeM2M

Movement-2-Music: Lakeshore Examination of Activity, Disability, and Exercise Response Study

Start: Aug 2019Est. completion: Sep 2025108 patients

N/ACompleted

NCT04171375 Angeles Therapeuticstrans-spinal Electrical Stimulation

Restorative Neuromodulation for Lower Extremity Functions

Start: Apr 2019Est. completion: Nov 20212 patients

N/ACompleted

NCT04215939 Petros PharmaceuticalsCold environment participants with spinal cord injury

Assessment of Vasomotion of People With Spinal Cord Injury

Start: Feb 2019Est. completion: Jul 202016 patients

N/ACompleted

NCT05003999 ColoplastHPC - SpeediCath ®

Time Needed to Perform Intermittent Catheterization in Adults With Spinal Cord Injuries

Start: Dec 2018Est. completion: Jun 201920 patients

N/ACompleted

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

2 late-stage (Phase 3) programs, potential near-term approvals

12 actively recruiting trials targeting 1,880 patients

30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.