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Rhinitis, Allergic, Seasonal

33
Pipeline Programs
18
Companies
35
Clinical Trials
4
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
0
9
0
14
7
Early DiscoveryClinical DevelopmentMarket

On Market (4)

Approved therapies currently available

ALVESCOApproved
ciclesonide
Unknown Company
inhalation2008
35M Part D
OMNARISApproved
ciclesonide
Unknown Company
nasal2007
923K Part D
ZETONNAApproved
ciclesonide
Unknown Company
nasal2012
323K Part D
MOMETASONE FUROATEApproved
mometasone
Unknown Company
nasal2017

Competitive Landscape

18 companies ranked by most advanced pipeline stage

ViiV Healthcare
ViiV HealthcareNC - Durham
19 programs
3
6
5
2
Fluticasone furoate and fexofenadinePhase 4
fluticasone furoate, fexofenadinePhase 4
GW685698Phase 3
GW685698XPhase 3
GW685698X Aqueous Nasal SprayPhase 3
+14 more programs
Integrated Biosciences
Integrated BiosciencesCA - San Carlos
1 program
1
MometasonePhase 41 trial
Active Trials
NCT00070707Completed188Est. Nov 2003
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
5 programs
1
4
CiclesonidePhase 31 trial
CiclesonidePhase 31 trial
CiclesonidePhase 31 trial
Ciclesonide Nasal SprayPhase 31 trial
Ciclesonide HFAPhase 21 trial
Active Trials
NCT00807053Completed480Est. Jul 2007
NCT00659594Completed500Est. Sep 2005
NCT00659503Completed420Est. Nov 2005
+2 more trials
MSD
MSDIreland - Ballydine
3 programs
2
Short ragweed pollen allergen extractPhase 31 trial
loratadine; montelukastPhase 31 trial
loratadineN/A1 trial
Active Trials
NCT00762983Completed1,003Est. Feb 2009
NCT02478398Completed1,025Est. Nov 2018
NCT00319995Completed1,095Est. Jun 2006
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
3 programs
2
Short ragweed pollen allergen extractPhase 3
loratadine; montelukastPhase 3
loratadineN/A
AbbVie
AbbVieNORTH CHICAGO, IL
1 program
1
olopatadine hydrochloride /ketorolac tromethamine fixed dose combination ophthalmic solutionPhase 31 trial
Active Trials
NCT01258309Completed129Est. Jan 2011
Astellas
AstellasChina - Shenyang
1 program
1
ASP4070Phase 2
Immunomic Therapeutics
1 program
1
ASP4070Phase 21 trial
Active Trials
NCT03101267Completed150Est. Oct 2018
GSK
GSKLONDON, United Kingdom
12 programs
Azelastine nasal sprayN/A1 trial
Fluticasone furoate nasal sprayN/A1 trial
Pirinase Hayfever Relief for Adults 0.05% Nasal SprayN/A1 trial
GSK256066PHASE_21 trial
GSK256066PHASE_21 trial
+7 more programs
Active Trials
NCT00117832Completed20Est. Oct 2006
NCT01337323Terminated3Est. Sep 2011
NCT02856282Completed46Est. Mar 2018
+9 more trials
UCB Pharma
UCB PharmaBelgium - Brussels
4 programs
Levocetirizine dihydrochlorideN/A1 trial
LevocetirizinePHASE_31 trial
levocetirizine dihydrochloridePHASE_31 trial
levocetirizine dihydrochloridePHASE_41 trial
Active Trials
NCT00521040Completed459Est. Jul 2004
NCT00315523Completed403Est. Oct 2006
NCT00544388Completed570Est. Jul 2004
+1 more trials
Dynavax Technologies
Dynavax TechnologiesCA - Emeryville
2 programs
Amb a 1 Immunostimulatory Oligoribonucleotide ConjugatePHASE_21 trial
Amb a 1 immunostimulatory oligodeoxyribonucleotide conjugatePHASE_21 trial
Active Trials
NCT00537355Completed271Est. May 2008
NCT00387738Terminated738Est. Mar 2008
Sandoz
SandozAustria - Kundl
2 programs
Fluticasone furoate 27.5 mcg/actuation nasal sprayPHASE_31 trial
Mometasone furoate 50 mcg/actuation nasal sprayPHASE_31 trial
Active Trials
NCT01279057Completed727Est. Feb 2011
NCT01038427Completed795Est. Feb 2010
Merck & Co.
Merck & Co.RAHWAY, NJ
1 program
loratadineN/A
Johnson & Johnson
Johnson & JohnsonNEW BRUNSWICK, NJ
1 program
C-1266-7PHASE_11 trial
Active Trials
NCT01500629Completed21Est. Dec 2012
Stallergenes Greer
Stallergenes GreerFrance - Antony
1 program
Sublingual tablet of ragweed pollen allergen extractPHASE_11 trial
Active Trials
NCT01224834Completed60Est. Oct 2009
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
1 program
BI 67100 ED 25 mgPHASE_21 trial
Active Trials
NCT01007721Completed146
Rigel Pharmaceuticals
Rigel PharmaceuticalsSOUTH SAN FRANCISCO, CA
1 program
R926112PHASE_21 trial
Active Trials
NCT00115089Completed375Est. Sep 2005
Hal Allergy
Hal AllergyNetherlands - Leiden
1 program
SUBLIVAC® Grasses/Placebo treatmentPHASE_3

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
GSKfluticasone furoate, fexofenadine
GSKFluticasone furoate and fexofenadine
Integrated BiosciencesMometasone
UCB Pharmalevocetirizine dihydrochloride
MSDShort ragweed pollen allergen extract
SandozFluticasone furoate 27.5 mcg/actuation nasal spray
AbbVieolopatadine hydrochloride /ketorolac tromethamine fixed dose combination ophthalmic solution
SandozMometasone furoate 50 mcg/actuation nasal spray
AstraZenecaCiclesonide Nasal Spray
UCB PharmaLevocetirizine
MSDloratadine; montelukast
GSKGW685698X Aqueous Nasal Spray
GSKGW685698
GSKGW685698X
GSKGW685698X Aqueous Nasal Spray

Showing 15 of 35 trials with date data

Clinical Trials (35)

Total enrollment: 13,346 patients across 35 trials

NCT00502775GSKfluticasone furoate, fexofenadine

Fluticasone Furoate Nasal Spray Versus Oral Fexofenadine

Start: Aug 2007Est. completion: Nov 2007680 patients
Phase 4Completed
NCT00435461GSKFluticasone furoate and fexofenadine

Fluticasone Furoate Nasal Spray Versus Oral Fexofenadine

Start: Dec 2006Est. completion: Feb 20071,000 patients
Phase 4Completed

Nasonex Compared With Placebo in Participants With Seasonal Allergic Rhinitis (SAR) and Concomitant Asthma (P03280)

Start: Apr 2003Est. completion: Nov 2003188 patients
Phase 4Completed
NCT00542607UCB Pharmalevocetirizine dihydrochloride

Efficacy and Safety of Levocetirizine and Fexofenadine in Reducing Symptoms of Seasonal Allergic Rhinitis

Start: Sep 2002Est. completion: Dec 200294 patients
Phase 4Completed
NCT02478398MSDShort ragweed pollen allergen extract

Efficacy and Safety Study of RAGWITEK™ (MK-3641) in Children With Ragweed-Induced Rhinoconjunctivitis With or Without Asthma (MK-3641-008)

Start: Jul 2015Est. completion: Nov 20181,025 patients
Phase 3Completed
NCT01279057SandozFluticasone furoate 27.5 mcg/actuation nasal spray

A Study Comparing Two Fluticasone Furoate Nasal Sprays in the Relief of the Signs and Symptoms of Seasonal Allergic Rhinitis

Start: Dec 2010Est. completion: Feb 2011727 patients
Phase 3Completed
NCT01258309AbbVieolopatadine hydrochloride /ketorolac tromethamine fixed dose combination ophthalmic solution

Safety and Efficacy of Olopatadine Hydrochloride/Ketorolac Tromethamine Ophthalmic Solution Compared With Olopatadine Hydrochloride Ophthalmic Solution in Patients With Seasonal Allergic Conjunctivitis

Start: Dec 2010Est. completion: Jan 2011129 patients
Phase 3Completed
NCT01038427SandozMometasone furoate 50 mcg/actuation nasal spray

A Study Comparing the Clinical Equivalence of Two Mometasone Nasal Sprays in the Relief of the Signs and Symptoms of Seasonal Allergic Rhinitis

Start: Dec 2009Est. completion: Feb 2010795 patients
Phase 3Completed
NCT00384475AstraZenecaCiclesonide Nasal Spray

A Study of Ciclesonide Nasal Spray in Patients 18 Years and Older With Seasonal Allergic Rhinitis (BY9010/M1-413)

Start: Oct 2006Est. completion: Jan 2007500 patients
Phase 3Completed
NCT00315523UCB PharmaLevocetirizine

Compare the Efficacy of Levocetirizine to Montelukast in Reducing Symptoms of SAR in Sensitive Subjects Exposed to Ragweed Pollen

Start: Jul 2006Est. completion: Oct 2006403 patients
Phase 3Completed
NCT00319995MSDloratadine; montelukast

Effects of Loratadine/Montelukast vs Pseudoephedrine and Placebo in Patients With Seasonal Allergic Rhinitis (Study P04095) (COMPLETED)

Start: Mar 2006Est. completion: Jun 20061,095 patients
Phase 3Completed
NCT00197262GSKGW685698X Aqueous Nasal Spray

Once-Daily Investigational Nasal Spray In Adults And Adolescents With Seasonal Allergic Rhinitis (SAR)

Start: Aug 2005Est. completion: Oct 2005288 patients
Phase 3Completed

Study Of Perennial Allergic Rhinitis

Start: Jun 2005Est. completion: Oct 200565 patients
Phase 3Completed

Study In Adults And Adolescents With Seasonal Allergic Rhinitis.

Start: May 2005Est. completion: Aug 2005288 patients
Phase 3Completed
NCT00118729GSKGW685698X Aqueous Nasal Spray

Study In Adolescent And Adult Subjects 12 Years Of Age And Older With Seasonal Allergic Rhinitis To Assess Onset of Action

Start: Apr 2005Est. completion: Aug 2005380 patients
Phase 3Completed
NCT00363740GSKGW685698X Aqueous Nasal Spray

Study of GW685698X In Patients With Seasonal Allergic Rhinitis

Start: Feb 2005Est. completion: Apr 200538 patients
Phase 3Completed

Study Using the Environmental Exposure Unit (EEU) to Assess the Onset of Action of Ciclesonide, Applied as a Nasal Spray in the Treatment of Seasonal Allergic Rhinitis (BY9010/M1-407)

Start: Feb 2005Est. completion: Nov 2005420 patients
Phase 3Completed

Study Using the Environmental Exposure Chamber (EEC) to Assess the Onset of Action of Ciclesonide, Applied as a Nasal Spray in Treatment of Seasonal Allergic Rhinitis (BY9010/M1-406)

Start: Nov 2004Est. completion: Sep 2005500 patients
Phase 3Completed
NCT00544388UCB Pharmalevocetirizine dihydrochloride

Efficacy of Levocetirizine and Cetirizine in Reducing Symptoms of Seasonal Allergic Rhinitis in Ragweed Sensitive Subjects

Start: Apr 2004Est. completion: Jul 2004570 patients
Phase 3Completed

To Assess the Safety and Efficacy of Ciclesonide, Applied as a Nasal Spray in the Treatment of Seasonal Allergic Rhinitis (BY9010/M1-401)

Start: Dec 2003Est. completion: Feb 2005302 patients
Phase 3Completed

A Dose-finding Study of ASP4070

Start: Apr 2017Est. completion: Oct 2018150 patients
Phase 2Completed

Randomized, Placebo Controlled, Crossover Study in an Environmental Challenge Chamber to Assess Safety & Efficacy of Three Oral Doses of BI 671800 Versus Fluticasone Propionate and Montelukast in Sensitive Seasonal Allergic Rhinitis Patients Out of Season

Start: Oct 2009146 patients
Phase 2Completed

A Phase II Study Evaluating Intranasal GSK256066 and Fluticasone Propionate in Subjects With Seasonal Allergic Rhinitis (SAR)

Start: Jan 2008Est. completion: May 200855 patients
Phase 2Completed
NCT00537355Dynavax TechnologiesAmb a 1 Immunostimulatory Oligoribonucleotide Conjugate

An Evaluation of the Efficacy and Safety of TOLAMBA™ for Ragweed-Allergic Rhinitis in an Environmental Exposure Chamber

Start: Sep 2007Est. completion: May 2008271 patients
Phase 2Completed
NCT00807053AstraZenecaCiclesonide HFA

Dose-ranging Study to Assess the Efficacy and Safety of Ciclesonide HFA Nasal Aerosol in Adult and Adolescent Patients 12 Years and Older With Seasonal Allergic Rhinitis (SAR) (BY9010/M1-602)

Start: Apr 2007Est. completion: Jul 2007480 patients
Phase 2Completed

A 5-way Treatment Period Trial of Single Doses of Intranasal GSK256066 in Patients With Rhinitis

Start: Mar 2007Est. completion: May 200732 patients
Phase 2Completed
NCT00387738Dynavax TechnologiesAmb a 1 immunostimulatory oligodeoxyribonucleotide conjugate

Efficacy and Safety Study of TOLAMBA™ in Ragweed-Allergic Adults

Start: Apr 2006Est. completion: Mar 2008738 patients
Phase 2Terminated

7 Day Study of Mast Cell Inhibitor, R926112, in Patients With Symptomatic Seasonal Allergic Rhinitis

Start: Jul 2005Est. completion: Sep 2005375 patients
Phase 2Completed

Study of a Topical Nasal Spray to Ease the Symptoms of Hayfever

Start: Jan 2012Est. completion: Dec 201221 patients
Phase 1Completed
NCT01224834Stallergenes GreerSublingual tablet of ragweed pollen allergen extract

Safety and Tolerability Study of Ragweed SLIT Tablets

Start: Jan 2009Est. completion: Oct 200960 patients
Phase 1Completed
NCT02856282GSKPirinase Hayfever Relief for Adults 0.05% Nasal Spray

Drug Utilization Study for Pirinase Hayfever Relief

Start: Feb 2016Est. completion: Mar 201846 patients
N/ACompleted
NCT01337323GSKFluticasone furoate nasal spray

Prospective Observational Study of Concomitant Allergic Rhinitis Treatment Patterns Among Patients Starting on Fluticasone Furoate Nasal Spray in a Retail Pharmacy Setting

Start: Sep 2010Est. completion: Sep 20113 patients
N/ATerminated
NCT00762983MSDloratadine

Observation of Use of Claritin (Loratadine) Tablet, RediTabs, and Dry Syrup in Children (Study P05834)(COMPLETED)

Start: Mar 2008Est. completion: Feb 20091,003 patients
N/ACompleted
NCT00117832GSKAzelastine nasal spray

Nasal Ocular Reflexes Contribute to Eye Symptoms

Start: Mar 2005Est. completion: Oct 200620 patients
N/ACompleted
NCT00521040UCB PharmaLevocetirizine dihydrochloride

Efficacy and Safety of Levocetirizine 8 Weeks Prior and After the Onset of the Grass Pollen Season in Subjects With SAR

Start: Feb 2004Est. completion: Jul 2004459 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

14 late-stage (Phase 3) programs, potential near-term approvals
18 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.