Presbyopia

14
Pipeline Programs
11
Companies
42
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
1
6
0
5
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

11 companies ranked by most advanced pipeline stage

AbbVie
AbbVieNORTH CHICAGO, IL
3 programs
1
1
1
AGN-190584Phase 41 trial
AGN-190584Phase 31 trial
AGN-241622Phase 1/21 trial
Active Trials
NCT04403763Terminated80Est. Dec 2022
NCT04837482Completed43Est. Dec 2021
NCT05624320Withdrawn0Est. Jun 2023
LENZ Therapeutics
LENZ TherapeuticsSOLANA BEACH, CA
9 programs
1
4
4
Aceclidine+Brimonidine combination ophthalmic solutionPhase 31 trial
Aceclidine+Brimonidine combination ophthalmic solutionPhase 31 trial
Aceclidine+Brimonidine combination ophthalmic solutionPhase 31 trial
Aceclidine+Brimonidine combination ophthalmic solutionPhase 31 trial
Aceclidine+Brimonidine combination ophthalmic solutionPhase 21 trial
+4 more programs
Active Trials
NCT06270030CompletedEst. Apr 2024
NCT05294328CompletedEst. Sep 2022
NCT05431543CompletedEst. Dec 2022
+6 more trials
S
SantenCA - Emeryville
1 program
1
0.1% STN1013600 ophthalmic solutionPhase 21 trial
Active Trials
NCT05665387Completed79Est. Jul 2023
Glaukos
GlaukosALISO VIEJO, CA
1 program
1
Pilocarpine Ophthalmic Topical Cream, Dose 1Phase 21 trial
Active Trials
NCT05124275CompletedEst. Sep 2022
Alcon
AlconFORT WORTH, TX
18 programs
3% hydrogen peroxide solution with HydraGlyde® Moisture MatrixN/A
DACP MFN/A1 trial
Deleficon AN/A1 trial
Delefilcon A multifocal contact lensesN/A1 trial
Lehfilcon A multifocal contact lensesN/A1 trial
+13 more programs
Active Trials
NCT02403180Completed70Est. Jul 2015
NCT06369987CompletedEst. Nov 2024
NCT01951573Completed36Est. Nov 2013
+13 more trials
Bausch + Lomb
Bausch + LombNJ - Bridgewater
4 programs
Investigational contact lensN/A1 trial
LD118033 contact lensN/A1 trial
LD127025 MFN/A1 trial
kalifilcon A Daily Disposable MultifocalN/A1 trial
Active Trials
NCT01518868Completed126Est. Feb 2012
NCT01539694Completed126Est. Mar 2012
NCT01959178Completed146Est. Aug 2013
+1 more trials
Bracco
BraccoItaly - Milan
3 programs
Glasses to correct presbyopiaN/A1 trial
Presbyopia screening trainingN/A1 trial
Reading glassN/A1 trial
Active Trials
NCT05510687Active Not RecruitingEst. Apr 2026
NCT03001258CompletedEst. Jun 2015
NCT03719196CompletedEst. Dec 2018
Novartis
NovartisBASEL, Switzerland
2 programs
3% hydrogen peroxide solution with HydraGlyde® Moisture MatrixN/A1 trial
Opti-Free® PureMoist® contact lens solutionN/A1 trial
Active Trials
NCT02965833Completed126Est. Mar 2017
NCT02965820Completed122Est. Apr 2017
J&
Johnson & JohnsonNEW BRUNSWICK, NJ
1 program
Acuvue Oasys for PresbyopiaN/A1 trial
Active Trials
NCT02228109Completed35Est. Apr 2015
STAAR Surgical
STAAR SurgicalCA - Lake Forest
1 program
EDOF ICLN/A1 trial
Active Trials
NCT03499821CompletedEst. Jul 2019
Abbott
AbbottABBOTT PARK, IL
1 program
iDesign 1.3-PRESBY treatmentN/A1 trial
Active Trials
NCT02806726Terminated42Est. Nov 2017

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
AbbVieAGN-190584
LENZ TherapeuticsAceclidine+Brimonidine combination ophthalmic solution
LENZ TherapeuticsAceclidine+Brimonidine combination ophthalmic solution
LENZ TherapeuticsAceclidine+Brimonidine combination ophthalmic solution
LENZ TherapeuticsAceclidine+Brimonidine combination ophthalmic solution
AbbVieAGN-190584
Santen0.1% STN1013600 ophthalmic solution
LENZ TherapeuticsAceclidine+Brimonidine combination ophthalmic solution
LENZ TherapeuticsAceclidine+Brimonidine combination ophthalmic solution
GlaukosPilocarpine Ophthalmic Topical Cream, Dose 1
LENZ TherapeuticsAceclidine+tropicamide combination
LENZ TherapeuticsPRX-100
AbbVieAGN-241622
LENZ TherapeuticsLNZ101
AlconLehfilcon A multifocal for astigmatism contact lenses

Showing 15 of 42 trials with date data

Clinical Trials (42)

Total enrollment: 1,374 patients across 42 trials

Using AGN-190584 in Subjects Utilizing Single -Use Daily, Contact Lenses

Start: Dec 2022Est. completion: Jun 20230
Phase 4Withdrawn
NCT06045299LENZ TherapeuticsAceclidine+Brimonidine combination ophthalmic solution

Evaluation of the Efficacy and Safety of LNZ101 and LNZ100 for the Presbyopia

Start: Sep 2023Est. completion: Jan 2025
Phase 3Completed
NCT05728944LENZ TherapeuticsAceclidine+Brimonidine combination ophthalmic solution

Phase 3 Efficacy Study of LNZ100 & LNZ101 for the Treatment of Presbyopia

Start: Mar 2023Est. completion: Jan 2024
Phase 3Completed
NCT05753189LENZ TherapeuticsAceclidine+Brimonidine combination ophthalmic solution

Phase 3 Safety Study for the Treatment of Presbyopia Subjects

Start: Feb 2023Est. completion: Feb 2024
Phase 3Completed
NCT05656027LENZ TherapeuticsAceclidine+Brimonidine combination ophthalmic solution

Phase 3 Evaluation of the Safety and Efficacy of LNZ100 & LNZ101 for the Treatment of Presbyopia

Start: Dec 2022Est. completion: Jan 2024
Phase 3Completed

A Study to Assess the Impact and Adverse Events of Topical Eyedrops of AGN-190584 on Night-driving Performance in Participants, 40 to 55 Years of Age

Start: May 2021Est. completion: Dec 202143 patients
Phase 3Completed
NCT05665387Santen0.1% STN1013600 ophthalmic solution

Study Assessing the Efficacy and Safety of STN1013600 Ophthalmic Solution 0.1% and 0.3% Compared With Placebo in Subjects With Presbyopia

Start: Dec 2022Est. completion: Jul 202379 patients
Phase 2Completed
NCT05431543LENZ TherapeuticsAceclidine+Brimonidine combination ophthalmic solution

Evaluation of the Safety and Effectiveness of Aceclidine (LNZ101) and Aceclidine + Brimonidine (LNZ100) in the Treatment of Presbyopia

Start: Aug 2022Est. completion: Dec 2022
Phase 2Completed
NCT05294328LENZ TherapeuticsAceclidine+Brimonidine combination ophthalmic solution

Evaluation of the Safety and Effectiveness of Aceclidine/Brimonidine (LNZ101) and Aceclidine (LNZ100) in the Treatment of Presbyopia

Start: May 2022Est. completion: Sep 2022
Phase 2Completed
NCT05124275GlaukosPilocarpine Ophthalmic Topical Cream, Dose 1

Safety and Efficacy of Pilocarpine Ophthalmic Topical Cream for the Treatment of Presbyopia

Start: Jan 2022Est. completion: Sep 2022
Phase 2Completed
NCT03201562LENZ TherapeuticsAceclidine+tropicamide combination

A Single-Center, Double-Masked Evaluation of the Efficacy and Safety of PRX-100 in the Treatment of Early to Moderate Presbyopia

Start: Apr 2017Est. completion: May 2018
Phase 2Completed

Evaluation of the Efficacy and Safety of PRX-100 in the Treatment of Early to Moderate Presbyopia

Start: Sep 2015Est. completion: Nov 2015
Phase 2Completed

Phase 1/2 Study of AGN-241622 in Healthy Participants and Participants With Presbyopia

Start: Jul 2020Est. completion: Dec 202280 patients
Phase 1/2Terminated

Safety, Tolerability and Pharmacokinetics of LNZ101 and LNZ100 Ophthalmic Solutions in Healthy Adult Chinese With Presbyopia

Start: Mar 2024Est. completion: Apr 2024
Phase 1Completed
NCT06461455AlconLehfilcon A multifocal for astigmatism contact lenses

Clinical Performance Evaluation of Two Frequent Replacement Silicone Hydrogel Multifocal Toric Contact Lenses

Start: Jul 2024Est. completion: Dec 2024
N/ACompleted
NCT06469242AlconSerafilcon A multifocal contact lenses

Clinical Performance of Two Frequent Replacement Silicone Hydrogel Multifocal Contact Lenses

Start: Jul 2024Est. completion: Oct 2024
N/ACompleted
NCT06369987AlconDeleficon A

Visual Performance of Dailies Total1 Multifocal and Acuvue Oasys Max 1-Day Multifocal in Presbyopic Lens Wearers

Start: Apr 2024Est. completion: Nov 2024
N/ACompleted
NCT05510687BraccoGlasses to correct presbyopia

Transforming Households With Refraction and Innovative Financial Technology

Start: Dec 2023Est. completion: Apr 2026
N/AActive Not Recruiting
NCT05702541AlconLehfilcon A multifocal contact lenses

Assessing the Clinical Performance of Two Frequent Replacement Silicone Hydrogel Multifocal Contact Lenses

Start: Jan 2023Est. completion: Feb 2023
N/ACompleted
NCT05338333AlconLehfilcon A multifocal contact lenses

Clinical Performance Evaluation of Two Frequent Replacement Silicone Hydrogel Multifocal Contact Lenses

Start: May 2022Est. completion: Sep 2022101 patients
N/ACompleted
NCT05325931Bausch + Lombkalifilcon A Daily Disposable Multifocal

1-Week Dispensing Evaluation of Kalifilcon A Daily Disposable Multifocal Compared to Ultra for Presbyopia

Start: Feb 2022Est. completion: Mar 202230 patients
N/ACompleted
NCT04474782AlconThere is not an intervention

Analysis of Defocus Curve of Pre-Presbyopic and Emerging Presbyopic Patients

Start: Oct 2019Est. completion: Aug 2020
N/ACompleted
NCT03757039AlconMultifocal soft contact lenses

Multifocal Visual Performance Study

Start: Dec 2018Est. completion: Mar 2019
N/ATerminated

Clinical Performance of a Phakic Intraocular Lens (IOL)

Start: Mar 2018Est. completion: Jul 2019
N/ACompleted
NCT03118934AlconLotrafilcon B multifocal contact lenses

Assessing Fitting Guides in Alcon Multifocal Contact Lenses

Start: May 2017Est. completion: Jul 2017188 patients
N/ACompleted
NCT03719196BraccoReading glass

Reading Glass on Livelihoods and Quality of Life in Rural Bangladesh

Start: Apr 2017Est. completion: Dec 2018
N/ACompleted
NCT02965820NovartisOpti-Free® PureMoist® contact lens solution

OPTI-FREE® PureMoist® for Presbyopic Contact Lens Wearers

Start: Dec 2016Est. completion: Apr 2017122 patients
N/ACompleted
NCT02965833Novartis3% hydrogen peroxide solution with HydraGlyde® Moisture Matrix

CLEAR CARE® PLUS for Presbyopic Contact Lens Wearers

Start: Dec 2016Est. completion: Mar 2017126 patients
N/ACompleted
NCT02806726AbbottiDesign 1.3-PRESBY treatment

Clinical Investigation iDesign System With 1.3-PRESBY Treatment and STAR S4 IR™ Excimer Laser System

Start: Jul 2016Est. completion: Nov 201742 patients
N/ATerminated

DAILIES® AquaComfort Plus® Multifocal (MF) - Comparative Assessment of Visual Performance

Start: May 2015Est. completion: Jul 201570 patients
N/ACompleted
NCT03001258BraccoPresbyopia screening training

Presbyopia Screening by Community Health Worker in Bangladesh

Start: Feb 2015Est. completion: Jun 2015
N/ACompleted
NCT02228109Johnson & JohnsonAcuvue Oasys for Presbyopia

Multifocal Lens Centration and Its Effect on Visual Performance in a Presbyopic Population

Start: Dec 2014Est. completion: Apr 201535 patients
N/ACompleted
NCT02235831AlconNelfilcon A MF contact lenses

DAILIES® AquaComfort Plus® Multifocal (MF) - Comparative Assessment of Visual Performance

Start: Sep 2014Est. completion: Oct 201424 patients
N/ACompleted
NCT02117544AlconLotrafilcon B multifocal contact lenses

Multifocal High ADD Contact Lens Proof of Concept Trial

Start: Apr 2014Est. completion: Jul 2014
N/ACompleted
NCT01951573AlconDelefilcon A multifocal contact lenses

Evaluation of a New Daily Disposable Multifocal Contact Lens Design

Start: Oct 2013Est. completion: Nov 201336 patients
N/ACompleted

A Study to Evaluate a Mid Add Multi-Focal Soft Contact Lens

Start: Jun 2013Est. completion: Aug 2013146 patients
N/ACompleted
NCT01518868Bausch + LombInvestigational contact lens

A Study to Evaluate the Feasibility of a High Add Multi Focal Contact Lens

Start: Jan 2012Est. completion: Feb 2012126 patients
N/ACompleted
NCT01539694Bausch + LombLD118033 contact lens

A Study to Evaluate the Product Performance of a Low Add MultiFocal Soft Contact Lens

Start: Jan 2012Est. completion: Mar 2012126 patients
N/ACompleted
NCT01254760AlconNelfilcon A multifocal contact lens, investigational

Comparison of Two Multifocal Contact Lenses Worn on a Daily Disposable Basis

Start: Dec 2010Est. completion: Jan 2011
N/ACompleted
NCT01250054AlconLotrafilcon B contact lens

Comparison of Two Multifocal Contact Lenses

Start: Oct 2010Est. completion: Oct 2010
N/ACompleted
NCT00909792AlconLotrafilcon B

Clinical Evaluation of Two New Silicone Hydrogel Multifocal Products

Start: May 2009Est. completion: Jun 2009
N/ACompleted
NCT00886119AlconLotrafilcon B multifocal contact lens

Comparison of a Multifocal Contact Lens to a Traditional Multifocal Contact Lens

Start: Apr 2009Est. completion: May 2009
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

5 late-stage (Phase 3) programs — potential near-term approvals
11 companies competing in this space