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Posttraumatic Stress Disorder

6
Pipeline Programs
18
Companies
27
Clinical Trials
2 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
1
4
Early DiscoveryClinical DevelopmentMarket

On Market (1)

Approved therapies currently available

PRAZOSIN HYDROCHLORIDEApproved
prazosin
Unknown Company
oral2024

Competitive Landscape

18 companies ranked by most advanced pipeline stage

Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
3 programs
1
PrazosinPhase 41 trial
An Exploration of the Relationship Between Chronic Pain and Suicide Attempt Among VeteransN/A1 trial
NightWareN/A1 trial
Active Trials
NCT01502436Completed230Est. Nov 2014
NCT05365607Completed40Est. Aug 2024
NCT03997864Withdrawn0Est. Aug 2021
MSD
MSDIreland - Ballydine
1 program
1
Adjunctive asenapinePhase 4
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
1 program
1
Adjunctive asenapinePhase 4
Human BioSciences
Human BioSciencesWV - Martinsburg
2 programs
1
Breath Water Sound Course and Traumatic Incident ReductionPhase 31 trial
Trauma-Focused Cognitive Behavioral TherapyN/A1 trial
Active Trials
NCT06535516Recruiting60Est. Aug 2028
NCT00290225Completed180Est. Dec 2005
Alliance Pharmaceuticals
2 programs
1
D-cycloserinePhase 21 trial
Using Data Science To Center Patient Perspectives in Mechanism DiscoveryN/A1 trial
Active Trials
NCT06233968Active Not Recruiting33Est. Dec 2026
NCT01157429Completed24Est. Jun 2012
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
4 programs
Connectd mobile applicationN/A1 trial
DBS of the Basolateral Nucleus of the AmygdalaN/A1 trial
RFPPN/A1 trial
Reminder Focused Positive PsychiatryN/A1 trial
Active Trials
NCT02954146Completed120Est. Mar 2018
NCT02091843Unknown6Est. Dec 2025
NCT04336072Completed11Est. Jun 2019
+1 more trials
Innovation Pharmaceuticals
2 programs
Cancer Distress Coach Mobile AppN/A1 trial
TF-CBTN/A1 trial
Active Trials
NCT02986152Completed569Est. Apr 2019
NCT05516368Completed120Est. Jan 2015
Biomed
BiomedAustralia - Sydney
1 program
Active MeRT TreatmentN/A1 trial
Active Trials
NCT02990793Completed158Est. Nov 2025
Cognition Therapeutics
Cognition TherapeuticsPA - Pittsburgh
1 program
Brief computerized interventionN/A1 trial
Active Trials
NCT02502513Completed56Est. Oct 2015
SPARK Biopharma
SPARK BiopharmaKorea - Seoul
1 program
Sparrow Ascent tANN/A1 trial
Active Trials
NCT06130501Active Not Recruiting20Est. Jun 2026
Spark Biomedical
Spark BiomedicalTX - Dallas
1 program
Sparrow Ascent tANN/A
Providence Therapeutics
1 program
Transcranial Magnetic StimulationN/A1 trial
Active Trials
NCT02273063Completed40Est. Apr 2016
Neuronetics
NeuroneticsMALVERN, PA
1 program
Transcranial Magnetic StimulationN/A
Young BioPharma
Young BioPharmaMA - Lowell
1 program
Trauma and Grief Component Therapy for AdolescentsN/A1 trial
Active Trials
NCT00480480Completed144Est. Oct 2001
Johnson & Johnson
Johnson & JohnsonNEW BRUNSWICK, NJ
1 program
VVC-delivered Massed Imaginal ExposureN/A1 trial
Active Trials
NCT05450224Withdrawn0Est. Jan 2024
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
1 program
Written Exposure TherapyN/A1 trial
Active Trials
NCT05950035Completed49Est. Jan 2025
Pfizer
PfizerNEW YORK, NY
1 program
sertralineN/A5 trials
Active Trials
NCT04446039Completed370,212Est. Nov 2022
NCT01607593Completed123Est. Oct 2012
NCT00677352Completed321Est. Feb 2010
+2 more trials
Merck & Co.
Merck & Co.RAHWAY, NJ
1 program
Adjunctive asenapinePHASE_41 trial
Active Trials
NCT01587118Completed18Est. Jul 2016

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
Colorado TherapeuticsPrazosin
Merck & Co.Adjunctive asenapine
Pfizersertraline
Human BioSciencesBreath Water Sound Course and Traumatic Incident Reduction
Pfizersertraline
Alliance PharmaceuticalsD-cycloserine
Pfizersertraline
Angeles TherapeuticsReminder Focused Positive Psychiatry
Human BioSciencesTrauma-Focused Cognitive Behavioral Therapy
SPARK BiopharmaSparrow Ascent tAN
Alliance PharmaceuticalsUsing Data Science To Center Patient Perspectives in Mechanism Discovery
Oregon TherapeuticsWritten Exposure Therapy
Johnson & JohnsonVVC-delivered Massed Imaginal Exposure
Pfizersertraline
Colorado TherapeuticsNightWare

Showing 15 of 27 trials with date data

Clinical Trials (27)

Total enrollment: 373,259 patients across 27 trials

NCT03997864Colorado TherapeuticsPrazosin

Administration of Prazosin to Prevent PTSD in Adult Women After Sexual Assault

Start: Feb 2020Est. completion: Aug 20210
Phase 4Withdrawn
NCT01587118Merck & Co.Adjunctive asenapine

An Open Label Pilot Study of Adjunctive Asenapine for the Treatment of Posttraumatic Stress Disorder

Start: Jun 2012Est. completion: Jul 201618 patients
Phase 4Completed
NCT00677352Pfizersertraline

A Study Of Sertraline Compared With Paroxetine In The Treatment Of Panic Disorder

Start: May 2008Est. completion: Feb 2010321 patients
Phase 4Completed
NCT00290225Human BioSciencesBreath Water Sound Course and Traumatic Incident Reduction

Yoga Breath Program and Client-Centered Exposure for Relief of PTSD in Tsunami Victims

Start: Jun 2005Est. completion: Dec 2005180 patients
Phase 3Completed
NCT00340379Pfizersertraline

Ziprasidone vs. Sertraline/Haloperidol in Psychotic Depression

Start: Apr 2003Est. completion: Aug 200572 patients
Phase 2/3Completed
NCT01157429Alliance PharmaceuticalsD-cycloserine

D-cycloserine Adjunctive Treatment for Posttraumatic Stress Disorder (PTSD) in Adolescents

Start: Jun 2010Est. completion: Jun 201224 patients
Phase 2Completed
NCT00215150Pfizersertraline

Geodon for the Treatment of Refractory Social Anxiety Disorder

Start: Nov 2004Est. completion: Jul 200951 patients
Phase 2Completed
NCT04529031Angeles TherapeuticsReminder Focused Positive Psychiatry

Biomolecular Characteristics of Reminder-Focused Positive-Psychiatry

Start: Apr 2026Est. completion: Dec 202860 patients
N/ARecruiting
NCT06535516Human BioSciencesTrauma-Focused Cognitive Behavioral Therapy

Resilient Roots: Supporting Youth and Families

Start: Jul 2024Est. completion: Aug 202860 patients
N/ARecruiting
NCT06130501SPARK BiopharmaSparrow Ascent tAN

tAN for PTSD and OUD in Buprenorphine Therapy

Start: Jul 2024Est. completion: Jun 202620 patients
N/AActive Not Recruiting
NCT06233968Alliance PharmaceuticalsUsing Data Science To Center Patient Perspectives in Mechanism Discovery

Using Data Science To Center Patient Perspectives in Mechanism Discovery

Start: Mar 2024Est. completion: Dec 202633 patients
N/AActive Not Recruiting
NCT05950035Oregon TherapeuticsWritten Exposure Therapy

An Efficient Treatment for Posttraumatic Injury for Firefighters

Start: Dec 2023Est. completion: Jan 202549 patients
N/ACompleted
NCT05450224Johnson & JohnsonVVC-delivered Massed Imaginal Exposure

Telehealth-Massed Imaginal Exposure for PTSD

Start: Jan 2023Est. completion: Jan 20240
N/AWithdrawn
NCT04446039Pfizersertraline

Non-interventional, Retrospective Cohort Study to Explore Antidepressant Treatment in Korea

Start: Jul 2022Est. completion: Nov 2022370,212 patients
N/ACompleted
NCT05365607Colorado TherapeuticsNightWare

NightWare and Cardiovascular Health in Adults With PTSD

Start: Jun 2022Est. completion: Aug 202440 patients
N/ACompleted
NCT02990793BiomedActive MeRT Treatment

Clinical Trial to Evaluate the Safety and Efficacy of MeRT Treatment in Post-Traumatic Stress Disorder

Start: Apr 2022Est. completion: Nov 2025158 patients
N/ACompleted
NCT02986152Innovation PharmaceuticalsCancer Distress Coach Mobile App

Cancer Distress Coach Mobile App Trial

Start: Jun 2017Est. completion: Apr 2019569 patients
N/ACompleted
NCT04336072Angeles TherapeuticsRFPP

Reminder Focused Positive Psychiatry in Adolescents With ADHD and PTSD

Start: Jan 2017Est. completion: Jun 201911 patients
N/ACompleted
NCT02954146Angeles TherapeuticsConnectd mobile application

Mobile Health Application for Family and Behavioral Health Provider Communication

Start: Nov 2016Est. completion: Mar 2018120 patients
N/ACompleted
NCT02273063Providence TherapeuticsTranscranial Magnetic Stimulation

rTMS for PTSD Comorbid With Major Depressive Disorder

Start: Oct 2014Est. completion: Apr 201640 patients
N/ACompleted
NCT02091843Angeles TherapeuticsDBS of the Basolateral Nucleus of the Amygdala

Deep Brain Stimulation of the Amygdala for Combat Post-Traumatic Stress Disorder

Start: Jan 2014Est. completion: Dec 20256 patients
N/AUnknown
NCT02502513Cognition TherapeuticsBrief computerized intervention

Prevention of Intrusive Memories and Posttraumatic Stress Symptoms After Emergency Cesarean Section

Start: Jun 2013Est. completion: Oct 201556 patients
N/ACompleted
NCT01607593Pfizersertraline

A Retrospective And Multicenter Survey To Investigate The Dosage, Efficacy And Safety Of Sertraline In Posttraumatic Stress Disorder Patients

Start: Aug 2012Est. completion: Oct 2012123 patients
N/ACompleted
NCT05516368Innovation PharmaceuticalsTF-CBT

TF-CBT for Long-term PTSD, Major Depressive Disorder and Anxiety Disorders in Victims of Terrorism

Start: Mar 2012Est. completion: Jan 2015120 patients
N/ACompleted
NCT01502436Colorado TherapeuticsAn Exploration of the Relationship Between Chronic Pain and Suicide Attempt Among Veterans

An Exploration of the Relationship Between Chronic Pain and Suicide Attempt Among Veterans

Start: Jun 2008Est. completion: Nov 2014230 patients
N/ACompleted
NCT00605813Pfizersertraline

Special Investigation Of Long Term Use Of Sertraline.

Start: Sep 2007Est. completion: Sep 2011542 patients
N/ACompleted
NCT00480480Young BioPharmaTrauma and Grief Component Therapy for Adolescents

Randomized Controlled Trial of the Effectiveness of Group Treatment With War-Exposed Bosnian Adolescents

Start: Sep 2000Est. completion: Oct 2001144 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
2 actively recruiting trials targeting 373,259 patients
18 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.