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Posttraumatic Stress Disorder

6
Pipeline Programs
18
Companies
27
Clinical Trials
2 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
1
4
Early DiscoveryClinical DevelopmentMarket

On Market (1)

Approved therapies currently available

PRAZOSIN HYDROCHLORIDEApproved
prazosin
Unknown Company
oral2024

Competitive Landscape

18 companies ranked by most advanced pipeline stage

Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
3 programs
1
PrazosinPhase 41 trial
An Exploration of the Relationship Between Chronic Pain and Suicide Attempt Among VeteransN/A1 trial
NightWareN/A1 trial
Active Trials
NCT01502436Completed230Est. Nov 2014
NCT05365607Completed40Est. Aug 2024
NCT03997864Withdrawn0Est. Aug 2021
MSD
MSDIreland - Ballydine
1 program
1
Adjunctive asenapinePhase 41 trial
Active Trials
NCT01587118Completed18Est. Jul 2016
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
1 program
1
Adjunctive asenapinePhase 4
Human BioSciences
Human BioSciencesWV - Martinsburg
2 programs
1
Breath Water Sound Course and Traumatic Incident ReductionPhase 31 trial
Trauma-Focused Cognitive Behavioral TherapyN/A1 trial
Active Trials
NCT06535516Recruiting60Est. Aug 2028
NCT00290225Completed180Est. Dec 2005
Alliance Pharmaceuticals
2 programs
1
D-cycloserinePhase 21 trial
Using Data Science To Center Patient Perspectives in Mechanism DiscoveryN/A1 trial
Active Trials
NCT06233968Active Not Recruiting33Est. Dec 2026
NCT01157429Completed24Est. Jun 2012
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
4 programs
Connectd mobile applicationN/A1 trial
DBS of the Basolateral Nucleus of the AmygdalaN/A1 trial
RFPPN/A1 trial
Reminder Focused Positive PsychiatryN/A1 trial
Active Trials
NCT02954146Completed120Est. Mar 2018
NCT02091843Unknown6Est. Dec 2025
NCT04336072Completed11Est. Jun 2019
+1 more trials
Innovation Pharmaceuticals
2 programs
Cancer Distress Coach Mobile AppN/A1 trial
TF-CBTN/A1 trial
Active Trials
NCT02986152Completed569Est. Apr 2019
NCT05516368Completed120Est. Jan 2015
Biomed
BiomedAustralia - Sydney
1 program
Active MeRT TreatmentN/A1 trial
Active Trials
NCT02990793Completed158Est. Nov 2025
Cognition Therapeutics
Cognition TherapeuticsPA - Pittsburgh
1 program
Brief computerized interventionN/A1 trial
Active Trials
NCT02502513Completed56Est. Oct 2015
SPARK Biopharma
SPARK BiopharmaKorea - Seoul
1 program
Sparrow Ascent tANN/A1 trial
Active Trials
NCT06130501Active Not Recruiting20Est. Jun 2026
Spark Biomedical
Spark BiomedicalTX - Dallas
1 program
Sparrow Ascent tANN/A
Neuronetics
NeuroneticsMALVERN, PA
1 program
Transcranial Magnetic StimulationN/A
Providence Therapeutics
1 program
Transcranial Magnetic StimulationN/A1 trial
Active Trials
NCT02273063Completed40Est. Apr 2016
Young BioPharma
Young BioPharmaMA - Lowell
1 program
Trauma and Grief Component Therapy for AdolescentsN/A1 trial
Active Trials
NCT00480480Completed144Est. Oct 2001
Johnson & Johnson
Johnson & JohnsonNEW BRUNSWICK, NJ
1 program
VVC-delivered Massed Imaginal ExposureN/A1 trial
Active Trials
NCT05450224Withdrawn0Est. Jan 2024
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
1 program
Written Exposure TherapyN/A1 trial
Active Trials
NCT05950035Completed49Est. Jan 2025
Pfizer
PfizerNEW YORK, NY
1 program
sertralineN/A5 trials
Active Trials
NCT04446039Completed370,212Est. Nov 2022
NCT01607593Completed123Est. Oct 2012
NCT00677352Completed321Est. Feb 2010
+2 more trials
Merck & Co.
Merck & Co.RAHWAY, NJ
1 program
Adjunctive asenapinePHASE_4

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
Colorado TherapeuticsPrazosin
MSDAdjunctive asenapine
Pfizersertraline
Human BioSciencesBreath Water Sound Course and Traumatic Incident Reduction
Pfizersertraline
Alliance PharmaceuticalsD-cycloserine
Pfizersertraline
Angeles TherapeuticsReminder Focused Positive Psychiatry
Human BioSciencesTrauma-Focused Cognitive Behavioral Therapy
SPARK BiopharmaSparrow Ascent tAN
Alliance PharmaceuticalsUsing Data Science To Center Patient Perspectives in Mechanism Discovery
Oregon TherapeuticsWritten Exposure Therapy
Johnson & JohnsonVVC-delivered Massed Imaginal Exposure
Pfizersertraline
Colorado TherapeuticsNightWare

Showing 15 of 27 trials with date data

Clinical Trials (27)

Total enrollment: 373,259 patients across 27 trials

NCT03997864Colorado TherapeuticsPrazosin

Administration of Prazosin to Prevent PTSD in Adult Women After Sexual Assault

Start: Feb 2020Est. completion: Aug 20210
Phase 4Withdrawn
NCT01587118MSDAdjunctive asenapine

An Open Label Pilot Study of Adjunctive Asenapine for the Treatment of Posttraumatic Stress Disorder

Start: Jun 2012Est. completion: Jul 201618 patients
Phase 4Completed
NCT00677352Pfizersertraline

A Study Of Sertraline Compared With Paroxetine In The Treatment Of Panic Disorder

Start: May 2008Est. completion: Feb 2010321 patients
Phase 4Completed
NCT00290225Human BioSciencesBreath Water Sound Course and Traumatic Incident Reduction

Yoga Breath Program and Client-Centered Exposure for Relief of PTSD in Tsunami Victims

Start: Jun 2005Est. completion: Dec 2005180 patients
Phase 3Completed
NCT00340379Pfizersertraline

Ziprasidone vs. Sertraline/Haloperidol in Psychotic Depression

Start: Apr 2003Est. completion: Aug 200572 patients
Phase 2/3Completed
NCT01157429Alliance PharmaceuticalsD-cycloserine

D-cycloserine Adjunctive Treatment for Posttraumatic Stress Disorder (PTSD) in Adolescents

Start: Jun 2010Est. completion: Jun 201224 patients
Phase 2Completed
NCT00215150Pfizersertraline

Geodon for the Treatment of Refractory Social Anxiety Disorder

Start: Nov 2004Est. completion: Jul 200951 patients
Phase 2Completed
NCT04529031Angeles TherapeuticsReminder Focused Positive Psychiatry

Biomolecular Characteristics of Reminder-Focused Positive-Psychiatry

Start: Apr 2026Est. completion: Dec 202860 patients
N/ARecruiting
NCT06535516Human BioSciencesTrauma-Focused Cognitive Behavioral Therapy

Resilient Roots: Supporting Youth and Families

Start: Jul 2024Est. completion: Aug 202860 patients
N/ARecruiting
NCT06130501SPARK BiopharmaSparrow Ascent tAN

tAN for PTSD and OUD in Buprenorphine Therapy

Start: Jul 2024Est. completion: Jun 202620 patients
N/AActive Not Recruiting
NCT06233968Alliance PharmaceuticalsUsing Data Science To Center Patient Perspectives in Mechanism Discovery

Using Data Science To Center Patient Perspectives in Mechanism Discovery

Start: Mar 2024Est. completion: Dec 202633 patients
N/AActive Not Recruiting
NCT05950035Oregon TherapeuticsWritten Exposure Therapy

An Efficient Treatment for Posttraumatic Injury for Firefighters

Start: Dec 2023Est. completion: Jan 202549 patients
N/ACompleted
NCT05450224Johnson & JohnsonVVC-delivered Massed Imaginal Exposure

Telehealth-Massed Imaginal Exposure for PTSD

Start: Jan 2023Est. completion: Jan 20240
N/AWithdrawn
NCT04446039Pfizersertraline

Non-interventional, Retrospective Cohort Study to Explore Antidepressant Treatment in Korea

Start: Jul 2022Est. completion: Nov 2022370,212 patients
N/ACompleted
NCT05365607Colorado TherapeuticsNightWare

NightWare and Cardiovascular Health in Adults With PTSD

Start: Jun 2022Est. completion: Aug 202440 patients
N/ACompleted
NCT02990793BiomedActive MeRT Treatment

Clinical Trial to Evaluate the Safety and Efficacy of MeRT Treatment in Post-Traumatic Stress Disorder

Start: Apr 2022Est. completion: Nov 2025158 patients
N/ACompleted
NCT02986152Innovation PharmaceuticalsCancer Distress Coach Mobile App

Cancer Distress Coach Mobile App Trial

Start: Jun 2017Est. completion: Apr 2019569 patients
N/ACompleted
NCT04336072Angeles TherapeuticsRFPP

Reminder Focused Positive Psychiatry in Adolescents With ADHD and PTSD

Start: Jan 2017Est. completion: Jun 201911 patients
N/ACompleted
NCT02954146Angeles TherapeuticsConnectd mobile application

Mobile Health Application for Family and Behavioral Health Provider Communication

Start: Nov 2016Est. completion: Mar 2018120 patients
N/ACompleted
NCT02273063Providence TherapeuticsTranscranial Magnetic Stimulation

rTMS for PTSD Comorbid With Major Depressive Disorder

Start: Oct 2014Est. completion: Apr 201640 patients
N/ACompleted
NCT02091843Angeles TherapeuticsDBS of the Basolateral Nucleus of the Amygdala

Deep Brain Stimulation of the Amygdala for Combat Post-Traumatic Stress Disorder

Start: Jan 2014Est. completion: Dec 20256 patients
N/AUnknown
NCT02502513Cognition TherapeuticsBrief computerized intervention

Prevention of Intrusive Memories and Posttraumatic Stress Symptoms After Emergency Cesarean Section

Start: Jun 2013Est. completion: Oct 201556 patients
N/ACompleted
NCT01607593Pfizersertraline

A Retrospective And Multicenter Survey To Investigate The Dosage, Efficacy And Safety Of Sertraline In Posttraumatic Stress Disorder Patients

Start: Aug 2012Est. completion: Oct 2012123 patients
N/ACompleted
NCT05516368Innovation PharmaceuticalsTF-CBT

TF-CBT for Long-term PTSD, Major Depressive Disorder and Anxiety Disorders in Victims of Terrorism

Start: Mar 2012Est. completion: Jan 2015120 patients
N/ACompleted
NCT01502436Colorado TherapeuticsAn Exploration of the Relationship Between Chronic Pain and Suicide Attempt Among Veterans

An Exploration of the Relationship Between Chronic Pain and Suicide Attempt Among Veterans

Start: Jun 2008Est. completion: Nov 2014230 patients
N/ACompleted
NCT00605813Pfizersertraline

Special Investigation Of Long Term Use Of Sertraline.

Start: Sep 2007Est. completion: Sep 2011542 patients
N/ACompleted
NCT00480480Young BioPharmaTrauma and Grief Component Therapy for Adolescents

Randomized Controlled Trial of the Effectiveness of Group Treatment With War-Exposed Bosnian Adolescents

Start: Sep 2000Est. completion: Oct 2001144 patients
N/ACompleted

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
2 actively recruiting trials targeting 373,259 patients
18 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.