Postoperative Complications

5
Pipeline Programs
7
Companies
7
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
0
0
1
3
Early DiscoveryClinical DevelopmentMarket

On Market (1)

Approved therapies currently available

U
BROMFENAC SODIUMApproved
bromfenac
Unknown Company
ophthalmic2022

Competitive Landscape

7 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
1 program
1
DonepezilPhase 41 trial
Active Trials
NCT00182845Completed30Est. Apr 2007
Fresenius Kabi
Fresenius KabiGermany - Bad Homburg
1 program
1
Hydroxyethyl Starch 130/0.4Phase 41 trial
Active Trials
NCT00308126Completed624Est. Sep 2006
Bausch + Lomb
Bausch + LombNJ - Bridgewater
1 program
1
BromfenacPhase 31 trial
Active Trials
NCT00198445Completed527Est. Jan 2004
Bausch Health
Bausch HealthQUEBEC, Quebec, Canada
1 program
1
MOA-728Phase 11 trial
Active Trials
NCT00311350CompletedEst. Aug 2006
Astellas
AstellasChina - Shenyang
1 program
Hyperinsulinemic Normoglycemic ClampN/A1 trial
Active Trials
NCT01001273Unknown80Est. Jun 2012
ADEL
ADELKorea - Seoul
1 program
Morphine SulfateN/A1 trial
Active Trials
NCT02962024CompletedEst. Oct 2018
City Therapeutics
City TherapeuticsMA - Cambridge
1 program
Patients Undergoing Low Tidal Volume Ventilation During CABGN/A1 trial
Active Trials
NCT07044102CompletedEst. Dec 2025

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Fresenius KabiHydroxyethyl Starch 130/0.4
PfizerDonepezil
Bausch + LombBromfenac
Bausch HealthMOA-728
City TherapeuticsPatients Undergoing Low Tidal Volume Ventilation During CABG
ADELMorphine Sulfate
AstellasHyperinsulinemic Normoglycemic Clamp

Clinical Trials (7)

Total enrollment: 1,261 patients across 7 trials

NCT00308126Fresenius KabiHydroxyethyl Starch 130/0.4

Study to Evaluate the Effect of Hydroxyethyl Starch (HES) in Complications of Patients After Abdominal Surgery

Start: Jun 2005Est. completion: Sep 2006624 patients
Phase 4Completed
NCT00182845PfizerDonepezil

Donepezil in the Prevention of Post-Operative Cognitive Decline

Start: Feb 2005Est. completion: Apr 200730 patients
Phase 4Completed
NCT00198445Bausch + LombBromfenac

Safety and Efficacy Study of Topical Bromfenac Versus Placebo to Treat Ocular Inflammation After Cataract Surgery

Start: May 2003Est. completion: Jan 2004527 patients
Phase 3Completed
NCT00311350Bausch HealthMOA-728

Study Evaluating the Safety of MOA-728 Administered Orally to Healthy Subjects

Start: Mar 2006Est. completion: Aug 2006
Phase 1Completed
NCT07044102City TherapeuticsPatients Undergoing Low Tidal Volume Ventilation During CABG

The Effect of Continuous Low Tidal Volume Ventilation During Cardiopulmonary Bypass on Renal Resistive Index

Start: Jul 2025Est. completion: Dec 2025
N/ACompleted
NCT02962024ADELMorphine Sulfate

Does Local Morphine Add to Local Anesthetics in Serratus Anterior Plane Block Has a System Analgesic Effect?

Start: Nov 2016Est. completion: Oct 2018
N/ACompleted
NCT01001273AstellasHyperinsulinemic Normoglycemic Clamp

Hyperinsulinemic Normoglycemic Clamp for Pancreas and Simultaneous Pancreas/Kidney Transplant Recipients

Start: Apr 2010Est. completion: Jun 201280 patients
N/AUnknown

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
7 companies competing in this space