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Postoperative Complications

6
Pipeline Programs
14
Companies
14
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
0
0
2
3
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

13 companies ranked by most advanced pipeline stage

Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
2 programs
1
SugammadexPhase 4
deep neuromuscular blockN/A
MSD
MSDIreland - Ballydine
2 programs
1
SugammadexPhase 41 trial
deep neuromuscular blockN/A1 trial
Active Trials
NCT03174223Completed460Est. Jul 2018
NCT02861131Completed200Est. Apr 2018
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
1 program
1
SugammadexPhase 4
Bausch Health
Bausch HealthQUEBEC, Quebec, Canada
2 programs
1
1
BromfenacPhase 31 trial
MOA-728Phase 11 trial
Active Trials
NCT00311350Completed48Est. Aug 2006
NCT00198445Completed527Est. Jan 2004
Bausch + Lomb
Bausch + LombNJ - Bridgewater
1 program
1
BromfenacPhase 3
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
2 programs
Applying goal-directed fluid therapy by continuous hemodynamic monitoring systemN/A1 trial
immunonutritionN/A1 trial
Active Trials
NCT02470221Completed600Est. Jul 2018
NCT05679661Recruiting590Est. Jan 2026
Eppendorf
EppendorfGermany - Hamburg
2 programs
Fibula ExplantationN/A1 trial
Treatment algorithm targeting individual cardiac outputN/A1 trial
Active Trials
NCT02265991Completed27Est. Jun 2014
NCT02834377Completed188Est. Oct 2017
Astellas
AstellasChina - Shenyang
1 program
Hyperinsulinemic Normoglycemic ClampN/A1 trial
Active Trials
NCT01001273Unknown80Est. Jun 2012
ADEL
ADELKorea - Seoul
1 program
Morphine sulfateN/A1 trial
Active Trials
NCT02962024Completed40Est. Oct 2018
City Therapeutics
City TherapeuticsMA - Cambridge
1 program
Patients Undergoing Low Tidal Volume Ventilation During CABGN/A1 trial
Active Trials
NCT07044102CompletedEst. Dec 2025
Medtronic
MedtronicNJ - Phillipsburg
1 program
TAPP Inguinal Hernia Repair With Self-fixating Parietex™ ProGrip™ MeshN/A1 trial
Active Trials
NCT01481376Completed200Est. Apr 2013
Kinamed
KinamedCA - Camarillo
1 program
pulsatile saline lavageN/A1 trial
Active Trials
NCT00736125Completed20Est. Mar 2011
Fresenius Kabi
Fresenius KabiGermany - Bad Homburg
1 program
Hydroxyethyl Starch 130/0.4PHASE_41 trial
Active Trials
NCT00308126Completed624Est. Sep 2006

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
MSDSugammadex
Fresenius KabiHydroxyethyl Starch 130/0.4
Bausch HealthBromfenac
Bausch HealthMOA-728
City TherapeuticsPatients Undergoing Low Tidal Volume Ventilation During CABG
UNION therapeuticsimmunonutrition
MSDdeep neuromuscular block
ADELMorphine sulfate
EppendorfTreatment algorithm targeting individual cardiac output
UNION therapeuticsApplying goal-directed fluid therapy by continuous hemodynamic monitoring system
MedtronicTAPP Inguinal Hernia Repair With Self-fixating Parietex™ ProGrip™ Mesh
EppendorfFibula Explantation
AstellasHyperinsulinemic Normoglycemic Clamp
Kinamedpulsatile saline lavage

Clinical Trials (14)

Total enrollment: 3,604 patients across 14 trials

NCT02861131MSDSugammadex

The Effect of Sugammadex Versus Neostigmine on Postoperative Pulmonary Complications

Start: Jan 2017Est. completion: Apr 2018200 patients
Phase 4Completed
NCT00308126Fresenius KabiHydroxyethyl Starch 130/0.4

Study to Evaluate the Effect of Hydroxyethyl Starch (HES) in Complications of Patients After Abdominal Surgery

Start: Jun 2005Est. completion: Sep 2006624 patients
Phase 4Completed
NCT00198445Bausch HealthBromfenac

Safety and Efficacy Study of Topical Bromfenac Versus Placebo to Treat Ocular Inflammation After Cataract Surgery

Start: May 2003Est. completion: Jan 2004527 patients
Phase 3Completed
NCT00311350Bausch HealthMOA-728

Study Evaluating the Safety of MOA-728 Administered Orally to Healthy Subjects

Start: Mar 2006Est. completion: Aug 200648 patients
Phase 1Completed
NCT07044102City TherapeuticsPatients Undergoing Low Tidal Volume Ventilation During CABG

The Effect of Continuous Low Tidal Volume Ventilation During Cardiopulmonary Bypass on Renal Resistive Index

Start: Jul 2025Est. completion: Dec 2025
N/ACompleted
NCT05679661UNION therapeuticsimmunonutrition

Perioperative Immunonutrition Intervention and Oral Decontamination in Elderly Surgical Patients

Start: Feb 2023Est. completion: Jan 2026590 patients
N/ARecruiting
NCT03174223MSDdeep neuromuscular block

Influence of Deep Versus Moderate Neuromuscular Blockade During General Anesthesia on 30-day Readmission Rates

Start: Jun 2017Est. completion: Jul 2018460 patients
N/ACompleted
NCT02962024ADELMorphine sulfate

Does Local Morphine Add to Local Anesthetics in Serratus Anterior Plane Block Has a System Analgesic Effect?

Start: Nov 2016Est. completion: Oct 201840 patients
N/ACompleted
NCT02834377EppendorfTreatment algorithm targeting individual cardiac output

Personalized Hemodynamic Therapy in Patients Undergoing High-risk Surgery

Start: May 2016Est. completion: Oct 2017188 patients
N/ACompleted
NCT02470221UNION therapeuticsApplying goal-directed fluid therapy by continuous hemodynamic monitoring system

Goal-directed Intraoperative Fluid Therapy in High-risk Surgery

Start: Mar 2016Est. completion: Jul 2018600 patients
N/ACompleted
NCT01481376MedtronicTAPP Inguinal Hernia Repair With Self-fixating Parietex™ ProGrip™ Mesh

TAPP Inguinal Hernia Repair With Self-fixating Parietex™ ProGrip™ Mesh

Start: Oct 2011Est. completion: Apr 2013200 patients
N/ACompleted
NCT02265991EppendorfFibula Explantation

Prospective Biomechanical Analysis of Donor-site Morbidity Following Microvascular Fibula Transplantation

Start: Sep 2011Est. completion: Jun 201427 patients
N/ACompleted
NCT01001273AstellasHyperinsulinemic Normoglycemic Clamp

Hyperinsulinemic Normoglycemic Clamp for Pancreas and Simultaneous Pancreas/Kidney Transplant Recipients

Start: Apr 2010Est. completion: Jun 201280 patients
N/AUnknown
NCT00736125Kinamedpulsatile saline lavage

A Study to Determine if Carbon Dioxide Lavage During Total Knee Surgery Reduces Intraoperative Embolic Events

Start: Dec 2007Est. completion: Mar 201120 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 3,604 patients
14 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.