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Pleural Effusion

1
Pipeline Programs
8
Companies
6
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
0
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

7 companies ranked by most advanced pipeline stage

Genentech
GenentechCA - Oceanside
1 program
1
Cathflo ActivasePhase 41 trial
Active Trials
NCT04806373Completed27Est. Dec 2023
Medical Metrics
Medical MetricsTX - Houston
1 program
Automatic Continuous Effusion Shunt implantationN/A1 trial
Active Trials
NCT06210685Active Not Recruiting25Est. Dec 2025
ResMed
ResMedSAN DIEGO, CA
1 program
Non-invasive ventilationN/A
Rhine Pharma
Rhine PharmaGermany - Heidelberg
1 program
Non-invasive ventilationN/A1 trial
Active Trials
NCT03189654Completed11Est. Mar 2020
Sequana Medical
Sequana MedicalGermany - Munich
1 program
The pleurapump systemN/A1 trial
Active Trials
NCT01952327Terminated2Est. Dec 2016
Rocket Pharmaceuticals
1 program
Vacuum-Based IPCN/A1 trial
Active Trials
NCT03831386Recruiting200Est. Dec 2026
Rein Therapeutics
1 program
LTI-01PHASE_21 trial
Active Trials
NCT04159831Completed44Est. Jul 2022

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
GenentechCathflo Activase
Rein TherapeuticsLTI-01
Medical MetricsAutomatic Continuous Effusion Shunt implantation
Rocket PharmaceuticalsVacuum-Based IPC
Rhine PharmaNon-invasive ventilation
Sequana MedicalThe pleurapump system

Clinical Trials (6)

Total enrollment: 309 patients across 6 trials

NCT04806373GenentechCathflo Activase

Intrapleural Fibrinolytic Therapy to Enhance Chemical Pleurodesis Enhance Chemical Pleurodesis

Start: Jun 2021Est. completion: Dec 202327 patients
Phase 4Completed
NCT04159831Rein TherapeuticsLTI-01

A Study to Evaluate LTI-01 in Patients With Infected, Non-draining Pleural Effusions

Start: Sep 2020Est. completion: Jul 202244 patients
Phase 2Completed
NCT06210685Medical MetricsAutomatic Continuous Effusion Shunt implantation

The ACES Study for Aseptic Pleural Effusion

Start: May 2024Est. completion: Dec 202525 patients
N/AActive Not Recruiting
NCT03831386Rocket PharmaceuticalsVacuum-Based IPC

Gravity Versus Vacuum Based Indwelling Tunneled Pleural Drainage System

Start: Jan 2019Est. completion: Dec 2026200 patients
N/ARecruiting
NCT03189654Rhine PharmaNon-invasive ventilation

Noninvasive Ventilation Therapy for the Treatment of Pleural Effusion in Patients With Heart Failure

Start: Jul 2017Est. completion: Mar 202011 patients
N/ACompleted
NCT01952327Sequana MedicalThe pleurapump system

Investigation Into the Automated Drainage of Recurrent Effusions From the Pleural Space in Thoracic Malignancy.

Start: May 2014Est. completion: Dec 20162 patients
N/ATerminated

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 actively recruiting trials targeting 309 patients
8 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.