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PCOS

5
Pipeline Programs
5
Companies
9
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
1
1
1
1
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Peptide
150%
Small Molecule
150%
+ 8 programs with unclassified modality

Competitive Landscape

5 companies ranked by most advanced pipeline stage

Human BioSciences
Human BioSciencesWV - Martinsburg
6 programs
1
1
1
Fiber-StatPhase 4Small Molecule1 trial
OCP + MetforminPhase 31 trial
Micronized progesteronePhase 11 trial
Eastern Siberia PCOS Epidemiology & Phenotype StudyN/A1 trial
diazoxideN/A1 trial
+1 more programs
Active Trials
NCT05194384Completed1,148Est. Dec 2019
NCT00683774Completed21Est. Dec 2008
NCT01112111Unknown225
+3 more trials
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
1
Semaglutide 3mg and 7mg [Rybelsus]Phase 2/3Peptide1 trial
Active Trials
NCT03919929Completed60Est. Oct 2023
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
1 program
1
DingkundanPhase 21 trial
Active Trials
NCT03264638Unknown315Est. Aug 2018
Genesis Therapeutics
Genesis TherapeuticsCA - Burlingame
1 program
mode of gonadotropin administrationN/A
City Therapeutics
City TherapeuticsMA - Cambridge
1 program
Metformin and SpironolactonePHASE_2_31 trial
Active Trials
NCT03981861CompletedEst. Jun 2019

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Human BioSciencesFiber-Stat
Human BioSciencesOCP + Metformin
Colorado TherapeuticsSemaglutide 3mg and 7mg [Rybelsus]
City TherapeuticsMetformin and Spironolactone
UNION therapeuticsDingkundan
Human BioSciencesMicronized progesterone
Human BioSciencesEastern Siberia PCOS Epidemiology & Phenotype Study
Human BioSciencesmode of gonadotropin administration
Human BioSciencesdiazoxide

Clinical Trials (9)

Total enrollment: 2,021 patients across 9 trials

NCT00703092Human BioSciencesFiber-Stat

Pilot Study:Role of Dietary Fiber in PCOS Anovulation

Start: Feb 2008Est. completion: Mar 20102 patients
Phase 4Terminated
NCT03229057Human BioSciencesOCP + Metformin

Comparing the Effects of Oral Contraceptive Pills Versus Metformin

Start: Jan 2018Est. completion: Jul 2024240 patients
Phase 3Completed
NCT03919929Colorado TherapeuticsSemaglutide 3mg and 7mg [Rybelsus]

Treating PCOS With Semaglutide vs Active Lifestyle Intervention

Start: May 2019Est. completion: Oct 202360 patients
Phase 2/3Completed
NCT03981861City TherapeuticsMetformin and Spironolactone

Metabolic and Neuro-Endocrine Effect of Treating PCOS in Adolescents

Start: Jul 2016Est. completion: Jun 2019
Phase 2/3Completed
NCT03264638UNION therapeuticsDingkundan

A Clinical and Biological Research of Combined Chinese and Western Medicine in the Treatment of PCOS

Start: Oct 2016Est. completion: Aug 2018315 patients
Phase 2Unknown
NCT04597099Human BioSciencesMicronized progesterone

Androgen Blockade and Progesterone Augmentation of Gonadotropin Secretion

Start: Oct 2022Est. completion: Oct 202510 patients
Phase 1Unknown
NCT05194384Human BioSciencesEastern Siberia PCOS Epidemiology & Phenotype Study

Eastern Siberia PCOS Epidemiology & Phenotype Study

Start: Apr 2016Est. completion: Dec 20191,148 patients
N/ACompleted
NCT01112111Human BioSciencesmode of gonadotropin administration

A Novel Stimulation Protocol and the Conventional Low Dose Step-up and Step Down Regimens

Start: May 2010225 patients
N/AUnknown
NCT00683774Human BioSciencesdiazoxide

Insulin and Polycystic Ovary Syndrome

Start: Nov 2005Est. completion: Dec 200821 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
5 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.