Pain, Postoperative

25
Pipeline Programs
11
Companies
15
Clinical Trials
13
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
5
1
3
16
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 14 programs with unclassified modality

On Market (13)

Approved therapies currently available

Bayer
ALEVEApproved
naproxen sodium
Bayer
oral1994
U
ANAPROXApproved
naproxen sodium
Unknown Company
oral1980
U
ANAPROX DSApproved
naproxen sodium
Unknown Company
oral1980
Pfizer
BEXTRAApproved
valdecoxib
Pfizer
oral2001
U
BUPIVACAINE LIPOSOMEApproved
bupivacaine
Unknown Company
Amide Local Anesthetic [EPC]injection2024
U
EXPARELApproved
bupivacaine
Unknown Company
Amide Local Anesthetic [EPC]injection2011
U
LYRICAApproved
pregabalin
Unknown Company
oral2004
U
NAPRELANApproved
naproxen sodium
Unknown Company
oral1996
U
NAPROXENApproved
naproxen sodium
Unknown Company
Nonsteroidal Anti-inflammatory Drug [EPC]oral1993
U
NAPROXEN SODIUMApproved
naproxen sodium
Unknown Company
oral2019
U
NAPROXEN SODIUM AND DIPHENHYDRAMINE HYDROCHLORIDEApproved
naproxen sodium
Unknown Company
oral2018
U
POSIMIRApproved
bupivacaine
Unknown Company
infiltration2021
U
PREGABALINApproved
pregabalin
Unknown Company
oral2026

Competitive Landscape

11 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
3 programs
2
1
valdecoxibPhase 4Small Molecule1 trial
DIC075VPhase 31 trial
pregabalinPhase 31 trial
Active Trials
NCT00726388Completed1,050Est. May 2009
NCT00468845Completed501Est. Oct 2010
NCT00650598CompletedEst. Aug 2004
Knight Therapeutics
Knight TherapeuticsQC - Montréal
1 program
1
BupivacainePhase 41 trial
Active Trials
NCT02222129Completed206Est. Dec 2013
Bayer
BayerLEVERKUSEN, Germany
1 program
1
Naproxen SodiumPhase 41 trial
Active Trials
NCT03404206Completed387Est. Jul 2018
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
1 program
1
ibuprofen + caffeinePhase 31 trial
Active Trials
NCT01929031Completed562Est. Mar 2014
Jazz Pharmaceuticals
Jazz PharmaceuticalsCA - Palo Alto
1 program
1
TetrahydrocannabinolPhase 2/31 trial
Active Trials
NCT02283281Unknown200Est. Dec 2024
M&
Merck & Co.RAHWAY, NJ
3 programs
3
MK0686Phase 21 trial
MK0719Phase 21 trial
MK2295Phase 21 trial
Active Trials
NCT00533403Completed114Est. Nov 2004
NCT00424424Terminated81Est. Jan 2007
NCT00387140Completed89Est. May 2007
Sintetica
SinteticaSwitzerland - Mendriosi
1 program
1
30 mg Paracetamol 3%Phase 21 trial
Active Trials
NCT03428230Completed60Est. Oct 2019
Bausch + Lomb
Bausch + LombNJ - Bridgewater
1 program
1
Topical Ocular BL1332 low dosePhase 21 trial
Active Trials
NCT07412496Not Yet Recruiting123Est. Feb 2027
City Therapeutics
City TherapeuticsMA - Cambridge
1 program
NRS 0. hourN/A1 trial
Active Trials
NCT06566859Not Yet RecruitingEst. Feb 2025
AM-Pharma
AM-PharmaNetherlands - Utrecht
1 program
Registry for Acute Pain TreatmentN/A1 trial
Active Trials
NCT02846610TerminatedEst. May 2023
Mission Therapeutics
Mission TherapeuticsUK - Cambridge
1 program
local infiltration and TAP blockN/A1 trial
Active Trials
NCT02997124Completed143Est. Nov 2016

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
BayerNaproxen Sodium
Knight TherapeuticsBupivacaine
Pfizervaldecoxib
Boehringer Ingelheimibuprofen + caffeine
PfizerDIC075V
Pfizerpregabalin
Jazz PharmaceuticalsTetrahydrocannabinol
Bausch + LombTopical Ocular BL1332 low dose
Sintetica30 mg Paracetamol 3%
Merck & Co.MK2295
Merck & Co.MK0719
Merck & Co.MK0686
City TherapeuticsNRS 0. hour
Mission Therapeuticslocal infiltration and TAP block
AM-PharmaRegistry for Acute Pain Treatment

Clinical Trials (15)

Total enrollment: 3,516 patients across 15 trials

NCT03404206BayerNaproxen Sodium

A Trial to Compare the Duration of Analgesic Efficacy and Safety of Naproxen Sodium Tablets and Ibuprofen Tablets in Postsurgical Dental Pain

Start: Feb 2018Est. completion: Jul 2018387 patients
Phase 4Completed

Efficacy of Liposomal Bupivacaine Versus 0.25% Bupivacaine for Laparoscopic Urologic Surgery

Start: Dec 2012Est. completion: Dec 2013206 patients
Phase 4Completed

A Multicentre, Double-Blind, Double-Dummy, Randomised Study of the Analgesic Efficacy and Safety of Valdecoxib Compared to Diclofenac Sodium in Patients Undergoing Knee Arthroscopy for Anterior Cruciate Ligament (ACL) Reconstruction

Start: Mar 2004Est. completion: Aug 2004
Phase 4Completed

Efficacy and Safety of Ibuprofen and Caffeine in Dental Pain

Start: Aug 2013Est. completion: Mar 2014562 patients
Phase 3Completed

An Open-Label Safety Study Of DIC075V (Intravenous Diclofenac Sodium) In Patients With Acute Post-Operative Pain

Start: Sep 2008Est. completion: May 20091,050 patients
Phase 3Completed

Study Of The Efficacy And Safety Of Pregabalin Compared To Placebo For Treatment Of Post-Surgical Pain From Hysterectomy

Start: Jun 2007Est. completion: Oct 2010501 patients
Phase 3Completed

Anesthetic Premedication With a Cannabis Extract (Cannapremed)

Start: May 2015Est. completion: Dec 2024200 patients
Phase 2/3Unknown
NCT07412496Bausch + LombTopical Ocular BL1332 low dose

A Study to Evaluate the Use of Topical Ocular BL1332 for the Management of Postoperative Ocular Pain Following Photorefractive Keratectomy

Start: Apr 2026Est. completion: Feb 2027123 patients
Phase 2Not Yet Recruiting
NCT03428230Sintetica30 mg Paracetamol 3%

Intrathecal Paracetamol Before Spinal Anaesthesia With Chloroprocaine HCl 1% for Short Knee Procedures

Start: Aug 2018Est. completion: Oct 201960 patients
Phase 2Completed

A Study to Evaluate the Safety and Efficacy of an Investigational Drug in the Treatment of Postoperative Dental Pain (MK-2295-005)

Start: Oct 2006Est. completion: May 200789 patients
Phase 2Completed

A Study to Evaluate the Efficacy of MK0719 in the Prevention of Postoperative Dental Pain (0719-002)

Start: Aug 2006Est. completion: Jan 200781 patients
Phase 2Terminated

MK0686 in Postsurgery Dental Pain (0686-002)

Start: Jul 2004Est. completion: Nov 2004114 patients
Phase 2Completed

Comparison of ESP Block and M-TAPA Block Efficiency in Postoperative Analgesia Management in Nephrectomy Cases

Start: Sep 2024Est. completion: Feb 2025
N/ANot Yet Recruiting
NCT02997124Mission Therapeuticslocal infiltration and TAP block

Transversus Abdominis Plane Block in Iliac Crest harvest-is it Beneficial?

Start: Apr 2016Est. completion: Nov 2016143 patients
N/ACompleted
NCT02846610AM-PharmaRegistry for Acute Pain Treatment

Registry for Acute Pain Treatment

Start: Sep 2007Est. completion: May 2023
N/ATerminated

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

3 late-stage (Phase 3) programs — potential near-term approvals
11 companies competing in this space