Pain Management

Pipeline Programs

Companies

Clinical Trials

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule

2100%

+ 15 programs with unclassified modality

Competitive Landscape

15 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

Colorado TherapeuticsCO - Louisville

1 program

Intrathecal morphinePhase 41 trial

Active Trials

NCT00880607Completed84Est. Sep 2012

Angeles TherapeuticsCA - Los Angeles

1 program

Local anaestheticPhase 41 trial

Active Trials

NCT04171050Completed44Est. Aug 2023

Avenue TherapeuticsFL - Bay Harbor Islands

1 program

tramadolPhase 33 trials

Active Trials

NCT03774836Active Not Recruiting360Est. Jun 2019

NCT03395808Completed251Est. May 2019

NCT03290378Completed409Est. Apr 2018

BioTherapeutics IncVA - Blacksburg

1 program

LTG-001 SDDPhase 1

UNION therapeuticsDenmark - Hellerup

3 programs

Continuous Paravertebral block with ropivacaineN/A1 trial

single-injection QLBN/A1 trial

Active Trials

NCT03990922Completed76Est. Nov 2019

NCT03942237Completed72Est. Sep 2019

NCT03844477Terminated25Est. May 2019

Oregon TherapeuticsFrance - Paris

1 program

COMmunity of Practice And Safety Support for Navigating PainN/A1 trial

Active Trials

NCT05492903Active Not Recruiting140Est. Sep 2026

PfizerNEW YORK, NY

1 program

CelecoxibN/ASmall Molecule

Zimmer BiometFL - Jacksonville

1 program

CelecoxibN/ASmall Molecule1 trial

Active Trials

NCT00474773Completed107Est. Dec 2009

BaxterCosta Rica - Cartago

1 program

Hylenex recombinant , morphine, salineN/A

Baxter InternationalDEERFIELD, IL

1 program

Hylenex recombinant , morphine, salineN/A1 trial

Active Trials

NCT00547664Completed88Est. Oct 2010

Flowonix MedicalNJ - Hackettstown

1 program

Intrathecal Drug Delivery SystemN/A1 trial

Active Trials

NCT02578459Withdrawn0Est. Sep 2018

Frontera TherapeuticsChina - Suzhou

1 program

Local cold therapy.N/A1 trial

Active Trials

NCT06974071Active Not Recruiting100Est. Dec 2025

Human BioSciencesWV - Martinsburg

1 program

Understanding the Postpartum Pain Experience in Women of Minority Race/EthnicityN/A1 trial

Active Trials

NCT04601246Completed49Est. Dec 2021

Rhythm PharmaceuticalsBOSTON, MA

1 program

Bupivacaine alone OR Bupivacaine-Ketorolac-KetaminePHASE_11 trial

Active Trials

NCT05575999Not Yet Recruiting200Est. Dec 2026

Latigo BiotherapeuticsCA - Thousand Oaks

1 program

LTG-001 SDDPHASE_11 trial

Active Trials

NCT07341152Completed14Est. Nov 2025

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

Angeles TherapeuticsLocal anaesthetic

Colorado TherapeuticsIntrathecal morphine

Avenue Therapeuticstramadol

Rhythm PharmaceuticalsBupivacaine alone OR Bupivacaine-Ketorolac-Ketamine

Latigo BiotherapeuticsLTG-001 SDD

Frontera TherapeuticsLocal cold therapy.

Oregon TherapeuticsCOMmunity of Practice And Safety Support for Navigating Pain

Human BioSciencesUnderstanding the Postpartum Pain Experience in Women of Minority Race/Ethnicity

UNION therapeuticsContinuous Paravertebral block with ropivacaine

UNION therapeuticssingle-injection QLB

Flowonix MedicalIntrathecal Drug Delivery System

Baxter InternationalHylenex recombinant , morphine, saline

Showing 15 of 16 trials with date data

Clinical Trials (16)

Total enrollment: 2,019 patients across 16 trials

NCT04171050 Angeles TherapeuticsLocal anaesthetic

Pudendal Enhancement of Enhanced Recovery After Surgery (ERAS) for Reconstructive Surgery (PEERS)

Start: Nov 2019Est. completion: Aug 202344 patients

Phase 4Completed

NCT00880607 Colorado TherapeuticsIntrathecal morphine

Intrathecal Morphine Versus Epidural Extended Release Morphine for Pediatric Patients Undergoing Spinal Fusion

Start: Dec 2008Est. completion: Sep 201284 patients

Phase 4Completed

NCT03774836 Avenue Therapeuticstramadol

Tramadol Versus Placebo and Morphine in the Management of Post-Operative Pain Abdominoplasty

Start: Dec 2018Est. completion: Jun 2019360 patients

Phase 3Active Not Recruiting

NCT03395808 Avenue Therapeuticstramadol

Evaluate Safety of Tramadol in the Management of Postoperative Pain Following Surgery

Start: Dec 2017Est. completion: May 2019251 patients

Phase 3Completed

NCT03290378 Avenue Therapeuticstramadol

Tramadol Versus Placebo in the Management of Postoperative Pain Following Bunionectomy

Start: Sep 2017Est. completion: Apr 2018409 patients

Phase 3Completed

NCT05575999 Rhythm PharmaceuticalsBupivacaine alone OR Bupivacaine-Ketorolac-Ketamine

Effectiveness of Bupivacaine, Ketorolac, Ketamine, vs Bupivacaine Alone in Reducing Postoperative Pocket Pain

Start: Jan 2026Est. completion: Dec 2026200 patients

Phase 1Not Yet Recruiting

NCT07341152 Latigo BiotherapeuticsLTG-001 SDD

A Study Comparing LTG-001 SDD Formulation To LTG-001 Crystalline Immediate Release Tablets In Healthy Participants

Start: Oct 2025Est. completion: Nov 202514 patients

Phase 1Completed

NCT06974071 Frontera TherapeuticsLocal cold therapy.

Effectiveness of Nonpharmacologic Therapies on Pain After Removal of Chest Drains in Postoperative Cardiac Surgery

Start: Apr 2025Est. completion: Dec 2025100 patients

N/AActive Not Recruiting

NCT05492903 Oregon TherapeuticsCOMmunity of Practice And Safety Support for Navigating Pain

COMmunity of Practice And Safety Support for Navigating Pain (COMPASS-NP)

Start: Aug 2023Est. completion: Sep 2026140 patients

N/AActive Not Recruiting

NCT04601246 Human BioSciencesUnderstanding the Postpartum Pain Experience in Women of Minority Race/Ethnicity

Understanding the Postpartum Pain Experience in Women of Minority Race/Ethnicity

Start: Dec 2020Est. completion: Dec 202149 patients

N/ACompleted

NCT03990922 UNION therapeuticsContinuous Paravertebral block with ropivacaine

CTPVB for Hepatectomy

Start: Jun 2019Est. completion: Nov 201976 patients

N/ACompleted

NCT03942237 UNION therapeuticssingle-injection QLB

Transmuscular Quadratus Lumborum Block for Postoperative Pain After Laparoscopic Adrenalectomy

Start: May 2019Est. completion: Sep 201972 patients

N/ACompleted

NCT03844477 UNION therapeuticssingle-injection QLB

Quadratus Lumborum Block : Effect on Acute Pain and Quality of Recovery After Laparoscopic Adrenalectomy

Start: Feb 2019Est. completion: May 201925 patients

N/ATerminated

NCT02578459 Flowonix MedicalIntrathecal Drug Delivery System

A Pilot Study to Evaluate the Efficacy of ITDD vs. CMM in the Treatment of Pancreatic Cancer Pain

Start: Apr 2016Est. completion: Sep 20180

N/AWithdrawn

NCT00547664 Baxter InternationalHylenex recombinant , morphine, saline

Efficacy of Hylenex in the Treatment of Pain Among Hospice Patients

Start: Jan 2008Est. completion: Oct 201088 patients

N/ACompleted

NCT00474773 Zimmer BiometCelecoxib

Evaluation of Post Hospital Administration of Celecoxib Following Minimally Invasive Knee Replacement Surgery

Start: Jun 2007Est. completion: Dec 2009107 patients

N/ACompleted

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals

16 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.