Pain, Acute

15
Pipeline Programs
3
Companies
3
Clinical Trials
13
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
0
0
0
14
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 2 programs with unclassified modality

On Market (13)

Approved therapies currently available

U
CHILDREN'S MOTRINApproved
ibuprofen
Unknown Company
Nonsteroidal Anti-inflammatory Drug [EPC]oral1996
U
IBUApproved
ibuprofen
Unknown Company
oral1986
U
IBU-TABApproved
ibuprofen
Unknown Company
oral1988
U
IBU-TAB 200Approved
ibuprofen
Unknown Company
oral1988
U
IBUPRINApproved
ibuprofen
Unknown Company
oral1987
U
IBUPROFENApproved
ibuprofen
Unknown Company
oral1987
U
IBUPROHMApproved
ibuprofen
Unknown Company
oral1985
U
JUNIOR STRENGTH IBUPROFENApproved
ibuprofen
Unknown Company
oral1999
U
JUNIOR STRENGTH MOTRINApproved
ibuprofen
Unknown Company
oral1996
U
MIDOL LIQUID GELSApproved
ibuprofen
Unknown Company
oral2002
U
MOTRIN IBApproved
ibuprofen
Unknown Company
oral1984
U
MOTRIN MIGRAINE PAINApproved
ibuprofen
Unknown Company
oral1984
U
RUFENApproved
ibuprofen
Unknown Company
oral1981

Competitive Landscape

3 companies ranked by most advanced pipeline stage

City Therapeutics
City TherapeuticsMA - Cambridge
1 program
1
IbuprofenPhase 4Small Molecule1 trial
Active Trials
NCT04630834UnknownEst. Jun 2022
Trevena
TrevenaPA - Chesterbrook
1 program
1
TRV130 1.5 mgPhase 11 trial
Active Trials
NCT02083315Completed30Est. Aug 2013
Bayer
BayerLEVERKUSEN, Germany
1 program
Digital Pain Reduction KitN/A1 trial
Active Trials
NCT03187132Completed245Est. May 2020

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
City TherapeuticsIbuprofen
TrevenaTRV130 1.5 mg
BayerDigital Pain Reduction Kit

Clinical Trials (3)

Total enrollment: 275 patients across 3 trials

NCT04630834City TherapeuticsIbuprofen

Ibuprofen Plus Acetaminophen for Enhanced Pain Reduction

Start: Mar 2021Est. completion: Jun 2022
Phase 4Unknown
NCT02083315TrevenaTRV130 1.5 mg

Pharmacokinetics and Pharmacodynamics of TRV130, Morphine, and Placebo in Healthy Subjects

Start: Jul 2013Est. completion: Aug 201330 patients
Phase 1Completed
NCT03187132BayerDigital Pain Reduction Kit

Development and Validation of a Digital Pain-Reduction Kit for Musculoskeletal Injuries

Start: Apr 2018Est. completion: May 2020245 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

3 companies competing in this space