Overweight or Obesity

Metabolic Diseases
4
Pipeline Programs
4
Companies
4
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
2
0
1
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Peptide
1100%
+ 3 programs with unclassified modality

Competitive Landscape

4 companies ranked by most advanced pipeline stage

MindRank
MindRankChina - Shanghai
1 program
1
MDR-001Phase 31 trial
Active Trials
NCT07274137Not Yet RecruitingEst. Jul 2027
Regeneron
RegeneronTARRYTOWN, NY
1 program
1
OlatorepatidePhase 2Peptide1 trial
Active Trials
NCT07431086Not Yet Recruiting120Est. Dec 2026
Terns Pharmaceuticals
Terns PharmaceuticalsFOSTER CITY, CA
1 program
1
TERN-601Phase 21 trial
Active Trials
NCT06854952CompletedEst. Sep 2025
Amgen
AmgenTHOUSAND OAKS, CA
1 program
1
AMG 133Phase 11 trial
Active Trials
NCT07429032Completed57Est. Nov 2025

Trial Timeline

Clinical trial activity over time

2025
2026
2027
MindRankMDR-001
RegeneronOlatorepatide
Terns PharmaceuticalsTERN-601
AmgenAMG 133

Clinical Trials (4)

Total enrollment: 177 patients across 4 trials

NCT07274137MindRankMDR-001

A Phase III Study to Evaluate the Efficacy and Safety of MDR-001 in Adult Participants With Overweight or Obesity (MOBILE）

Start: Feb 2026Est. completion: Jul 2027
Phase 3Not Yet Recruiting
NCT07431086RegeneronOlatorepatide

Study of Olatorepatide in Adult Participants Living With Overweight or Obesity in the US

Start: Mar 2026Est. completion: Dec 2026120 patients
Phase 2Not Yet Recruiting
NCT06854952Terns PharmaceuticalsTERN-601

A Clinical Study to Evaluate the Efficacy, Safety, and Tolerability of TERN-601 in Adults With Overweight or Obesity

Start: Mar 2025Est. completion: Sep 2025
Phase 2Completed
NCT07429032AmgenAMG 133

The Effect of AMG 133 on Gastric Emptying

Start: Apr 2025Est. completion: Nov 202557 patients
Phase 1Completed

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
4 companies competing in this space

Related Indications

Diabetes(737)Diabetes Mellitus, Type 2(485)Obesity(246)Type 2 Diabetes(207)Type 2 Diabetes Mellitus(190)Diabetes Mellitus(127)Diabetes Mellitus, Type 1(95)Type 1 Diabetes Mellitus(51)Type 1 Diabetes(50)Dyslipidemia(45)