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Osteopenia

11
Pipeline Programs
22
Companies
20
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
1
0
4
5
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

19 companies ranked by most advanced pipeline stage

Sandoz
SandozAustria - Kundl
4 programs
1
2
1
zoledronic acid vs pamidronatePhase 41 trial
Zoledronic AcidPhase 31 trial
zoledronic acidPhase 31 trial
BPS804 20mg/KgPhase 21 trial
Active Trials
NCT01406548Completed44Est. Oct 2013
NCT00132808Completed581Est. Feb 2008
NCT00145275Completed455Est. Oct 2005
+1 more trials
MSD
MSDIreland - Ballydine
2 programs
1
alendronate sodiumPhase 41 trial
Study of Bone Disease in Older HIV-infected AdultsN/A1 trial
Active Trials
NCT00935935Completed101Est. Feb 2011
NCT00504166Completed53Est. Apr 2009
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
2 programs
1
alendronate sodiumPhase 4
Study of Bone Disease in Older HIV-infected AdultsN/A
Medtronic
MedtronicNJ - Phillipsburg
1 program
1
Balloon KyphoplastyPhase 41 trial
Active Trials
NCT00211211Completed300Est. Dec 2007
Spine BioPharma
Spine BioPharmaNY - New York
1 program
1
Balloon KyphoplastyPhase 4
Bayer
BayerLEVERKUSEN, Germany
1 program
1
MenostarPhase 31 trial
Active Trials
NCT00310531Completed500Est. Jun 2007
Physical Sciences
Physical SciencesMA - Andover
1 program
1
wellness control group.Phase 31 trial
Active Trials
NCT01296776Completed78Est. Dec 2012
Pfizer
PfizerNEW YORK, NY
1 program
1
RN564Phase 11 trial
Active Trials
NCT01293487Completed68Est. May 2012
Solarea Bio
Solarea BioMA - Waltham
2 programs
Medical Food SBD111N/A
SBD111N/A
Biocorp
BiocorpFrance - Issoire
2 programs
Medical Food SBD111N/A1 trial
SBD111N/A1 trial
Active Trials
NCT05009875Completed286Est. Aug 2024
NCT07538167Not Yet Recruiting80Est. Feb 2027
TheraNova
TheraNovaCA - San Francisco
2 programs
Spry BeltN/A1 trial
Wearable vibration beltN/A1 trial
Active Trials
NCT03986203Unknown140Est. May 2022
NCT03688282Completed18Est. Apr 2019
GE HealthCare
1 program
Lunar ProdigyN/A1 trial
Active Trials
NCT01530477Terminated82Est. Dec 2012
Innovation Pharmaceuticals
1 program
Red clover extractN/A1 trial
Active Trials
NCT02174666Completed85Est. Nov 2016
Bone Health Technologies
Bone Health TechnologiesCA - San Francisco
1 program
Spry BeltN/A1 trial
Active Trials
NCT05457036Completed94Est. Dec 2023
Merck & Co.
Merck & Co.RAHWAY, NJ
1 program
Study of Bone Disease in Older HIV-infected AdultsN/A
Genentech
GenentechCA - Oceanside
1 program
bisphosphonate therapyN/A1 trial
Active Trials
NCT00145704Terminated6Est. Oct 2008
Ultragenyx Pharmaceutical
1 program
BPS804 20mg/KgPHASE_2
Mereo BioPharma
Mereo BioPharmaUK - London
1 program
BPS804 20mg/KgPHASE_2
Teva
TevaIsrael - Petach Tikva
1 program
SeasonalePHASE_32 trials
Active Trials
NCT00117260Withdrawn0Est. Aug 2007
NCT00117273Completed36Est. Jun 2006

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
MSDalendronate sodium
MedtronicBalloon Kyphoplasty
Sandozzoledronic acid vs pamidronate
Physical Scienceswellness control group.
TevaSeasonale
TevaSeasonale
Sandozzoledronic acid
SandozZoledronic Acid
BayerMenostar
SandozBPS804 20mg/Kg
PfizerRN564
BiocorpSBD111
Bone Health TechnologiesSpry Belt
BiocorpMedical Food SBD111
TheraNovaSpry Belt

Showing 15 of 20 trials with date data

Clinical Trials (20)

Total enrollment: 3,063 patients across 20 trials

NCT00504166MSDalendronate sodium

Alendronate Prevents Microarchitectural Deterioration of Trabecular Bone in Early Postmenopausal Women

Start: Feb 2006Est. completion: Apr 200953 patients
Phase 4Completed
NCT00211211MedtronicBalloon Kyphoplasty

FREE Study - Fracture Reduction Evaluation

Start: Feb 2003Est. completion: Dec 2007300 patients
Phase 4Completed
NCT00164008Sandozzoledronic acid vs pamidronate

Comparison of Pamidronate With Zoledronic Acid for Transplant Related Bone Loss Prevention

Start: Oct 2002Est. completion: Dec 200556 patients
Phase 4Completed
NCT01296776Physical Scienceswellness control group.

Effect of Electromyostimulation on Bone

Start: Jan 2011Est. completion: Dec 201278 patients
Phase 3Completed

Study to Evaluate the Safety and Efficacy of Seasonale for Treatment of Low Bone Mineral Density

Start: Jul 2005Est. completion: Aug 20070
Phase 3Withdrawn

A Study to Evaluate Suppression of the Pituitary-Ovarian Axis With Three Different Oral Contraceptive Regimens

Start: Jun 2005Est. completion: Jun 200636 patients
Phase 3Completed
NCT00145275Sandozzoledronic acid

To Assess the Efficacy of Over-the-counter Analgesics in the Prevention/Treatment of Transient Post-dose Symptoms Following Zoledronate Infusion in Post-menopausal Women

Start: Dec 2004Est. completion: Oct 2005455 patients
Phase 3Completed
NCT00132808SandozZoledronic Acid

Zoledronic Acid in the Prevention of Bone Loss in Postmenopausal Women With Osteopenia, 45 Years of Age and Older

Start: Jul 2004Est. completion: Feb 2008581 patients
Phase 3Completed

3-year Study of Menostar Versus Evista to Prevent Osteoporosis in Post-menopausal Women

Start: Feb 2004Est. completion: Jun 2007500 patients
Phase 3Completed
NCT01406548SandozBPS804 20mg/Kg

Safety and Efficacy of Multiple Dosing Regimens of BPS804 in Post Menopausal Women With Low Bone Mineral Density

Start: Jul 2011Est. completion: Oct 201344 patients
Phase 2Completed

Safety And Tolerability Study Of RN564 In Women With Osteopenia And Healthy Men.

Start: Apr 2011Est. completion: May 201268 patients
Phase 1Completed

Food Trial Evaluating Fecal Abundance of SBD111 With Once-Daily Versus Twice-Daily Administration in Healthy Adults

Start: Apr 2026Est. completion: Feb 202780 patients
N/ANot Yet Recruiting

Evaluation of the Effect of Spry Belt Treatment on Bone Turnover Marker Profile

Start: Sep 2022Est. completion: Dec 202394 patients
N/ACompleted
NCT05009875BiocorpMedical Food SBD111

Food Trial Evaluating the Efficacy of SBD111 Versus Placebo for the Clinical Dietary Management of the Metabolic Processes of Osteopenia

Start: Dec 2021Est. completion: Aug 2024286 patients
N/ACompleted

Evaluation of the Spry Belt for Improving Bone Quality

Start: Aug 2019Est. completion: May 2022140 patients
N/AUnknown
NCT03688282TheraNovaWearable vibration belt

Wearable Vibration Device to Prevent Bone Loss in Postmenopausal Women--Aim 2

Start: Jul 2018Est. completion: Apr 201918 patients
N/ACompleted

Isoflavone Treatment for Postmenopausal Osteopenia.

Start: Jun 2014Est. completion: Nov 201685 patients
N/ACompleted

DXA Precision and Accuracy Comparison Study

Start: Jan 2012Est. completion: Dec 201282 patients
N/ATerminated
NCT00935935MSDStudy of Bone Disease in Older HIV-infected Adults

Study of Bone Disease in Older HIV-infected Adults

Start: Dec 2009Est. completion: Feb 2011101 patients
N/ACompleted
NCT00145704Genentechbisphosphonate therapy

Study of Adults With Low Growth Hormone Who Survived Childhood Cancer Where Treatment Caused Low Bone Density

Start: Jun 2002Est. completion: Oct 20086 patients
N/ATerminated

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

4 late-stage (Phase 3) programs, potential near-term approvals
22 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.