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Osteoarthritis of Knee

4
Pipeline Programs
7
Companies
7
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
1
1
0
1
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

7 companies ranked by most advanced pipeline stage

Daewon Pharma
Daewon PharmaKorea - Hwaseong
1 program
1
Pelubiprofen CR 45mg tab.Phase 41 trial
Active Trials
NCT02682524Completed191Est. Mar 2016
Huons
HuonsKorea - Seongnam
1 program
1
Humia inj.Phase 31 trial
Active Trials
NCT02893098Completed232Est. Apr 2018
Nordic Pharma
Nordic PharmaFrance - Paris
1 program
1
MM-II dose IPhase 21 trial
Active Trials
NCT04506463Completed397Est. Aug 2022
Britecyte
BritecyteMD - Frederick
1 program
1
Cryopreserved Devitalized Adipose Tissue AllograftPhase 1/21 trial
Active Trials
NCT06828666Active Not Recruiting42Est. Aug 2026
City Therapeutics
City TherapeuticsMA - Cambridge
1 program
Genicular nerve pulse radiofrequencyN/A1 trial
Active Trials
NCT06894147Active Not RecruitingEst. May 2025
IBSA Institut Biochimique
IBSA Institut BiochimiqueSwitzerland - Lugano-Pazzallo
1 program
SinovialN/A1 trial
Active Trials
NCT06652893Completed50Est. Nov 2022
Stempeutics Research
Stempeutics ResearchIndia - Bangalore
1 program
Ex- vivo cultured adult allogeneic MSCsPHASE_21 trial
Active Trials
NCT01453738Completed60Est. Nov 2014

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Daewon PharmaPelubiprofen CR 45mg tab.
HuonsHumia inj.
Nordic PharmaMM-II dose I
Stempeutics ResearchEx- vivo cultured adult allogeneic MSCs
BritecyteCryopreserved Devitalized Adipose Tissue Allograft
City TherapeuticsGenicular nerve pulse radiofrequency
IBSA Institut BiochimiqueSinovial

Clinical Trials (7)

Total enrollment: 972 patients across 7 trials

NCT02682524Daewon PharmaPelubiprofen CR 45mg tab.

Phase IV Clinical Trial to Evaluate the Efficacy and Safety of PlbCR and Aceclofenac in the Treatment of Patients With Osteoarthritis of the Knee

Start: Aug 2015Est. completion: Mar 2016191 patients
Phase 4Completed
NCT02893098HuonsHumia inj.

A Study to Evaluate the Safety and Efficacy of Humia Inj. in Patients With Symptomatic Osteoarthritis of the Knee

Start: Aug 2016Est. completion: Apr 2018232 patients
Phase 3Completed
NCT04506463Nordic PharmaMM-II dose I

Efficacy and Safety of MM-II for Treatment of Knee Pain in Subjects With Symptomatic Knee Osteoarthritis

Start: Dec 2020Est. completion: Aug 2022397 patients
Phase 2Completed
NCT01453738Stempeutics ResearchEx- vivo cultured adult allogeneic MSCs

Allogeneic Mesenchymal Stem Cells in Osteoarthritis

Start: Nov 2011Est. completion: Nov 201460 patients
Phase 2Completed
NCT06828666BritecyteCryopreserved Devitalized Adipose Tissue Allograft

A Phase 1/2a to Evaluate the Safety and Efficacy of Adipose Tissue Allograft (BRC-OA) in Patients With Osteoarthritis of the Knee

Start: May 2025Est. completion: Aug 202642 patients
Phase 1/2Active Not Recruiting
NCT06894147City TherapeuticsGenicular nerve pulse radiofrequency

Genicular Radiofrequency Ablation Versus Pulsed Radiofrequency

Start: Apr 2024Est. completion: May 2025
N/AActive Not Recruiting
NCT06652893IBSA Institut BiochimiqueSinovial

Efficacy and Safety of Sinovial®HL Single Injection in the Knee Osteoarthritis

Start: Oct 2021Est. completion: Nov 202250 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
7 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.