Opioid Withdrawal
3
Pipeline Programs
1
Companies
2
Clinical Trials
1
Approved Products
Pipeline by Development Stage
Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
1
2
Early DiscoveryClinical DevelopmentMarket
On Market (1)
Approved therapies currently available
U
LOFEXIDINE HYDROCHLORIDEApproved
lofexidine
Unknown Companyoral2025
Competitive Landscape
1 companies ranked by most advanced pipeline stage
US WorldMedsKY - Louisville
2 programs1
1
Lofexidine Oral TabletPhase 41 trial
LofexidinePhase 31 trial
Active Trials
Trial Timeline
Clinical trial activity over time
2021
2022
2023
2024
2025
2026
US WorldMedsLofexidine Oral Tablet
US WorldMedsLofexidine
Clinical Trials (2)
Total enrollment: 286 patients across 2 trials
Lofexidine for Adults Undergoing Lumbar Spine Surgery
Start: Sep 2019Est. completion: Apr 2021
Phase 4Completed
Open-Label, Safety Study of Lofexidine
Start: Feb 2015Est. completion: Oct 2015286 patients
Phase 3Completed
Phase Legend
Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available
Key Insights
1 late-stage (Phase 3) programs — potential near-term approvals
1 companies competing in this space